Acute and Subchronic Toxicities of Indonesian Mistletoes Dendrophthoe pentandra L. (Miq.) Ethanol Extract

Mustarichie, Resmi; Warya, Sohadi; Saptarini, Nyi Mekar; Musfiroh, Ida

doi:10.7324/japs.2016.60916

Cited by 17 publications

(20 citation statements)

References 4 publications

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“…If the solution became red, then blue and finally bluish-green in color, it indicated the presence of steroidal nucleus while the formation of purple or red color indicated the presence of a triterpenoidal nucleus. The Extraction was carried out by maceration with alcohol 70% according to Mustarichie et.al method 15 . The extract was dried with the aid of a rotary evaporator.…”

Section: Methodsmentioning

confidence: 99%

Formulation of Black Hair Dyes in the Form of Sticks From Papaya Seed Extracts and Powder

Megantara¹,

Mustarichie²

2019

Int. Res. J. Pharm.

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In general, Indonesian people assume that black hair is healthy, fertile, and beautiful hair, while hair that is not black, especially white, is considered unhealthy. Traditionally papaya seeds (Carica papaya L.) are used as a hair blackened, which is felt less practical because the material must be processed first by frying it without oil (roasting) and added with coconut oil, then applied to the hair. The purpose of this study was to formulate a black hair dye in the form of stick from papaya seed and its powder. The study began with the collection and determination of papaya sample. The papaya seed was milled and examined its characteristics on moisture content, ash content and phytochemical screening. Then the papaya seed extract was made by maceration with alcohol 70 %. Six formula black hair in sticks form was designed with various powder concentrations (25%, 35%, and 45%) and extracts (2.5%, 3.5%, and 4, 5%) papaya seeds. Against the preparation, it was examined about the homogeneous test, consistency test, effectiveness test, and safety test. It was found that the water content of 4.66% w/w and ash content of 6.30% w/w were found in powder seed. Quinone was not found in the phytochemical screening. The six preparations made in a rod shape was good, stable, effective, and safe in its use. Statistically, it can be concluded that papaya seed extract can be formulated into hair blackening preparations that meet cosmetic requirements. The most effective and safe formula was a formula with 4.5% papaya seed extract.

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Section: Methodsmentioning

confidence: 99%

Formulation of Black Hair Dyes in the Form of Sticks From Papaya Seed Extracts and Powder

Megantara¹,

Mustarichie²

2019

Int. Res. J. Pharm.

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“…39 It was also interestingly found that leaf samples of S. ferruginea with higher flavonoids did not demonstrate prominent antiinflammation, despite the contribution of flavonoids including quercetin and its derivatives for inflammatory inhibition being extensively reported. 19,[40][41][42] The results showed by PLS biplot that the two identified flavonols quercitrin and 4″-O-acetylquercitrin, with VIP values of 0.76 and 1.21 were located in the vicinity of leaf samples but far from the bioactivity. This observation implies that the two flavonoids might not contribute significantly to the activities and could not be the phytochemical markers for anti-inflammation of S. ferruginea.…”

Section: Mvda Of Different Plant Parts Samplesmentioning

confidence: 99%

Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

Xiang

Isa

Fakurazi

et al. 2019

Phytochemical Analysis

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Introduction Scurrula ferruginea (Jack) Danser is a hemi‐parasitic shrub that is widely used as a traditional herbal medicine. Objectives To elucidate the anti‐inflammatory activity of S. ferruginea parasitising on three different hosts of Vitex negundo L., Micromelum minutum (G. Forst.) Wight & Arn. and Tecoma stans (L.) Juss ex HBK., as well as, to determine the metabolite differences related to their anti‐inflammatory properties. Materials and Methods Two plant parts of S. ferruginea, stems and leaves, were extracted in water. The freeze‐dried stem of S. ferruginea grown on T. stans was liquid–liquid partitioned into several solvents. Their potential anti‐inflammatory activity was assessed via inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) and interferon‐γ (IFN‐γ)‐induced RAW 264.7 macrophage cells. The metabolite variation was examined using proton nuclear magnetic resonance (1H‐NMR) combined with multivariate data analysis (MVDA). Results Scurrula ferruginea stems parasitising on T. stans and V. negundo which were freeze dried exhibited higher anti‐inflammatory activity with IC50 values of 114.47 ± 2.96 and 118.87 ± 2.31 μg/mL, respectively. The mid‐polar ethyl acetate fraction of S. ferruginea hosted on T. stans displayed the highest NO inhibition with 84.80 ± 0.45% at 200 μg/mL. Principal component analysis (PCA) indicated notable and clear discriminations among the different plant parts and host plants based on the identified metabolites. Furthermore, partial least squares (PLS) regression model suggested the anti‐inflammatory bioactivity might be associated with the presence of choline, isoleucine, catechin, leucine and chlorogenic acid. Conclusion This study suggests S. ferruginea could serve as a potential anti‐inflammatory agent, highlighting the importance of T. stans as the host plant.

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“…Phytochemical screening was carried out to determine the content of secondary metabolites guidance by Farnsworth method [14]. This test included: Flavonoid Test, the 0.5 g fraction was added to a cup and then added with 2 ml of 70% ethanol then stirred.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

A Comparison Study of Hair Tonic and Gel Formulation of Angiopteris Evecta as a Hair Growth Stimulant

et al. 2019

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Objective: Previous research has proven that the water fraction of the Angiopteris evecta root has hair growth activities. The objective of this research was to determine the formula of gel and hair tonic preparations of pakis munding (Angiopteris evecta L.) which met the requirements as a pharmaceutical preparation, good and effective in stimulating hair growth. Methods: Formulation of hair tonic and gel preparations were made using 7.5, 10.0, and 12.5 % of A. Evecta root water extracts as active compounds. The formulation of the two preparations was based on the standard formulation method. The evaluation and formulation test were carried out by organoleptic examination and homogeneity, pH, viscosity, scattering power test, stability test, and safety test based on the standard preparations including Indonesian pharmacopeia. Statistical tests were carried out on both formulas against rabbits based on the modification of the Tanaka method. Comparison of statistics on both formulas was also carried out. Results: It was found both formulas fulfill standard requirements as pharmaceutical preparations. Statistically, the best activity in hair tonic preparations was at a concentration of 12.5% and for gels at a concentration of 10.0% ethanol extract seen from measurements of hair length. Statistically, using the Independent T-test to find out the significant differences in the average hair length on hair tonic and gel, it was found there was no significant difference between the two formulas. It was found that the best formula for hair tonic and gel was in the addition of 10.0% and 12.5% extracts, respectively. Conclusion: The results obtained in this research work clearly indicated that both hair tonic and gel formulas of A. evecta root water extract may be used as stimulating hair growth.

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Acute and Subchronic Toxicities of Indonesian Mistletoes Dendrophthoe pentandra L. (Miq.) Ethanol Extract

Cited by 17 publications

References 4 publications

Formulation of Black Hair Dyes in the Form of Sticks From Papaya Seed Extracts and Powder

Formulation of Black Hair Dyes in the Form of Sticks From Papaya Seed Extracts and Powder

Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

A Comparison Study of Hair Tonic and Gel Formulation of Angiopteris Evecta as a Hair Growth Stimulant

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