Acute Cadmium Intoxication: Influence of Cyproterone Acetate on the Testis and Epididymis of the Rat

To provide a structural basis for region‐specific biochemical activities of rat epididymal cells and to assess the morphometric effects of vasectomy, tissue and cellular morphologic parameters for each of six histologically defined regions from the epididymis of long‐term sham‐operated and vasectomized rats were analyzed stereologically. In sham‐operated rats, tubule diameter generally increased from region 1 to region 6 (163 μm to 338 μm) while tubular wall height decreased (35 μm to 17.5 μm) as did tubular wall volume density (0.48 to 0.12). For columnar epithelial cells, the absolute cell number/region ranged from 16.5 to 5.1 × 106 such that region 2 > region 1 > region 5 > region 4 > region 6 > region 3. Based on cell volume, the largest columnar epithelial cells were found in region 3 (2607 ± 127 μm3). The epididymal tubule wall was made up of 91% columnar epithelial cells, 5% lymphocytes, and 4% basal cells. The relatively small tubular lumen, large wall volume, and large columnar epithelial cell number in the caput (regions 1 to 3) provide the structural basis for maximizing biochemical interactions between columnar epithelial cells and spermatozoa. In contrast, the distal cauda (region 6), with its large lumen and small tubular wall volume, is structurally optimized for the function of storage, which requires minimal columnar epithelial cell interaction with spermatozoa. In vasectomized rats, mean tissue volumes for most epididymal regions were significantly greater than in sham rats. The absolute number of lymphocytes in vasectomized rats significantly increased in several regions, thus implicating them in post‐vasectomy events.

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Morphometric Analyses of the Epididymis from Normal and Vasectomized Rats

Miller

Killian

1987

Journal of Andrology

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Acute Cadmium Exposure Causes Systemic and Thromboembolic Events in Mice

Fahim

Dhanasekaran²,

Singh³

et al. 2012

Physiol Res

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Cadmium (Cd), an environmental and industrial pollutant, poses a potential threat and affects many systems in human and animals. Although several reports on Cd toxicity were presented, the acute effect of Cd on systemic and thrombotic events was not reported so far. Cd (2.284 mg/kg) or saline (control) was injected intraperitoneally (ip), and the systemic parameters were assessed in mice. Compared to control group, acute intraperitoneal injection of Cd, in mice showed significant quickening of platelet aggregation (P<0.001) leading to pial cerebral thrombosis. Likewise, Cd exposure caused a significant increase in white blood cell numbers (P<0.05) indicating the occurrence of systemic inflammation. Also, alanine aminotransferase (ALT) (P<0.05) and creatinine (P<0.01) levelswere both significantly increased. Interestingly, the superoxide dismutase activity was significantly decreased in Cd treated group compared to control group (P<0.001), suggesting the occurrence of oxidative stress. We conclude that the Cd exposure in mice causes acute thromboembolic events, oxidative stress and alter liver and kidney functions.

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Acute Cadmium Intoxication: Influence of Cyproterone Acetate on the Testis and Epididymis of the Rat

Cited by 2 publications

References 18 publications

Morphometric Analyses of the Epididymis from Normal and Vasectomized Rats

Morphometric Analyses of the Epididymis from Normal and Vasectomized Rats

Acute Cadmium Exposure Causes Systemic and Thromboembolic Events in Mice

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