Acute changes in lung function associated with proximity to a steel plant: A randomized study

Dales, Robert; Kauri, Lisa Marie; Cakmak, Sabit; Mahmud, Mamun; Weichenthal, Scott; Ryswyk, Keith Van; Kumarathasan, Premkumari; Thomson, Errol M.; Vincent, Renaud; Broad, Gayle; Liu, Ling

doi:10.1016/j.envint.2013.01.014

Cited by 23 publications

(25 citation statements)

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“…A study in China showed that persistent toxic substances from these industries have doubled the risk of developing dermatitis in people living in proximity [ 47 ]. According to a Brazilian study, living near aluminium smelters has been associated with four folds increase respiratory disease admissions [ 48 ], whereas a Canadian study showed that living near iron smelters has been associated with acutely declining lung functions [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Health impacts from living near a major industrial park in Oman

Wahaibi

Zeka

2015

BMC Public Health

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Background: Oman is heading towards heavy industrialisation with rapid establishment of new industrial parks. One of these, the Sohar Industrial Zone (SIZ) started to operate in 2006 and includes many industries that potentially affect local air quality and the health status of its surrounding residents. The study aim was to assess the health effects in a population of ≥20 years old, living in the residential area around the SIZ. Methods: Area-specific health care visits data for acute respiratory diseases (ARD), asthma, conjunctivitis and dermatitis were obtained for the period between January 1, 2006, and December 31, 2010. Exposure was defined as distance from the SIZ to determine high, intermediate, and control exposure zones (≤5, >5-10, and ≥20 km from the SIZ respectively). Generalized additive models were used to model age and gender adjusted monthly health events for the selected diseases, adjusted for age and gender-specific population smoking prevalence. The high and intermediate exposure zones were later combined in the models because of their similarity of effects. Exposure effect modification by age, gender and socio-economic status (SES) were examined. Results: Living within the high and intermediate exposure zones was associated with a greater risk ratio for ARD (RR: 2.02; 95 % CI: 1.88-2.17), asthma (RR: 3.61; 95 % CI: 2.96-4.41), conjunctivitis (RR: 2.83; 95 % CI: 2.47-3.24), and dermatitis (RR: 2.11; 95 % CI: 1.86-2.39), compared to the control exposure zone. Greater exposure effects were observed amongst ages ≥50 years and lower SES groups. Conclusion: This is the first study carried out in Oman to assess the link between environmental exposure and health. These findings hope to contribute to building up evidence for environmental health and sustainable development policy in the country.

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Section: Discussionmentioning

confidence: 99%

Health impacts from living near a major industrial park in Oman

Wahaibi

Zeka

2015

BMC Public Health

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“…The study was approved by the Health Canada Research Ethics Board (reference number 2009-0044) and the ethics board at Algoma University. Study design and detailed methods of the study protocol have been reported previously [ 18 – 20 ]. Briefly, eligible study participants were recruited through postings at local university and college campuses.…”

Section: Methodsmentioning

confidence: 99%

“…The study compared physiological and biological responses in healthy volunteers who had spent time outdoors either at a location in a neighbourhood, called Bayview, adjacent to a steel mill, or at a college campus several kilometers from the steel mill. Previous reports of the results from this study have focussed on pulmonary function [ 18 ] and cardiovascular function [ 19 ], as well as the role of metals composition in the effects of particulate matter on pulmonary and cardiovascular function [ 20 ]. The current report focuses on associations between proximity to a steel plant and acute (same day) changes in HRV.…”

Section: Introductionmentioning

confidence: 99%

Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study

et al. 2017

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BackgroundEpidemiological studies have shown that as ambient air pollution (AP) increases the risk of cardiovascular mortality also increases. The mechanisms of this effect may be linked to alterations in autonomic nervous system function. We wished to examine the effects of industrial AP on heart rate variability (HRV), a measure of subtle changes in heart rate and rhythm representing autonomic input to the heart.MethodsSixty healthy adults were randomized to spend five consecutive 8-h days outdoors in one of two locations: (1) adjacent to a steel plant in the Bayview neighbourhood in Sault Ste Marie Ontario or (2) at a College campus, several kilometers from the plant. Following a 9–16 day washout period, participants spent five consecutive days at the other site. Ambient AP levels and ambulatory electrocardiogram recordings were collected daily. HRV analysis was undertaken on a segment of the ambulatory ECG recording during a 15 min rest period, near the end of the 8-h on-site day. Standard HRV parameters from both time and frequency domains were measured. Ambient AP was measured with fixed site monitors at both sites. Statistical analysis was completed using mixed-effects models.ResultsCompared to the College site, HRV was statistically significantly reduced at the Bayview site by 13% (95%CI 3.6,19.2) for the standard deviation of normal to normal, 8% (95%CI 0.1, 4.9) for the percent normal to normal intervals differing by more than 50 ms, and 15% (95%CI 74.9, 571.2) for low frequency power. Levels of carbon monoxide, sulphur dioxide, nitrogen dioxide, and fine and ultrafine particulates were slightly, but statistically significantly, elevated at Bayview when compared to College. Interquartile range changes in individual air pollutants were significantly associated with reductions in HRV measured on the same day. The patterns of effect showed a high degree of consistency, with nearly all pollutants significantly inversely associated with at least one measure of HRV.ConclusionsThe significant associations between AP and changes in HRV suggest that ambient AP near a steel plant may impact autonomic nervous system control of the heart.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0206-0) contains supplementary material, which is available to authorized users.

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“…These emissions may be an important source of environmental exposure for populations in nearby residential communities. For example, a study of healthy subjects in Ontario, Canada found that lung function measures were significantly lower after subjects spent five consecutive days in a neighborhood adjacent to a steel plant when compared to 5 days spent on a college campus farther away [ 5 ]. Furthermore, even after the cessation of ferroalloy production, these populations can continue to be exposed through inhalation of re-suspended particles [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

et al. 2016

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Background: Release of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity. Methods: As part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11-14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has historic ferroalloy activity and Garda Lake which has no history of ferroalloy activity. Particulate matter <10 μm in diameter (PM 10 ) was collected for 24 h in filters using personal sampling. Mn, nickel (Ni), zinc (Zn), chromium (Cr) and iron (Fe) were measured in filters using x-ray fluorescence. Data on respiratory health was collected through questionnaire. Data for 280 adolescents were analyzed using a modified Poisson regression, and risk ratios were calculated for an interquartile (IQR) range increase in each pollutant. Results: In adjusted models including PM 10 as a co-pollutant, we found significant associations between concentrations of Mn (RR: 1.09, 95 % CI [1.00,

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Acute changes in lung function associated with proximity to a steel plant: A randomized study

Cited by 23 publications

References 30 publications

Health impacts from living near a major industrial park in Oman

Health impacts from living near a major industrial park in Oman

Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study

Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

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