Acute childhood leukemia in a patient with hemophilia: First report in Japan

Kawakami, Kiyoshi; Takezaki, Toshiro; Nakazono, S; Kitahara, Takuma; Ikarimoto, Naoaki; Tanaka, Yuji; Miyata, Koichiro; Yoshioka, Akira

doi:10.1111/j.1442-200x.1994.tb03138.x

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Thirty‐two cases of leukaemia in patients with concomitant haemophilia were identified and details are displayed in Table 1 [4–26]. The cases ranged in age from 8 months to 40 years.…”

Section: Resultsmentioning

confidence: 99%

Malignancy in patients with haemophilia: a review of the literature

Dunn

2010

Haemophilia

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Haemophilia A and B are rare X-linked conditions. Elevated rates of HIV and hepatitis C related malignancies in these patients are well reported, however rates of other types of cancers are not. Therefore, a retrospective literature review of cancer in patients with haemophilia was conducted. A Medline search of articles from January 1966 to July 2009 utilizing the keywords haemophilia, leukaemia, malignancy, mortality, neoplasm and cancer was performed. The articles were reviewed and additional relevant publications were located from the references. Data on age, type and severity of haemophilia, HIV status, type of malignancy and outcomes were recorded as available. Thirty-two cases of leukaemia were identified as well as 159 malignant solid tumours. Specific incidence and prevalence rates could not be calculated due to the limited nature of the information available in the reports. Many types of malignancy have been reported in persons with haemophilia irrespective of infection with HIV and hepatitis C yet prevalence and incidence rates compared to the general population remain unknown. Patients with haemophilia can manifest non infectious related malignancies and symptomatic patients should be evaluated accordingly.

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“…Thirty‐two cases of leukaemia in patients with concomitant haemophilia were identified and details are displayed in Table 1 [4–26]. The cases ranged in age from 8 months to 40 years.…”

Section: Resultsmentioning

confidence: 99%

Malignancy in patients with haemophilia: a review of the literature

Dunn

2010

Haemophilia

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“…HIV damages the immune system and the resultant immunosuppression may lead to the development of malignant tumours such as lymphomas [3–5]. On the other hand, development of any kind of malignancy in HIV‐negative haemophiliacs is very important within the context of determination of sensitivity and treatment of haemophilia and the malignancy [6,7].…”

Section: Introductionmentioning

confidence: 99%

Two patients with haemophilia and acute leukaemia

Zülfikar¹

2002

Haemophilia

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Acute leukaemia is the commonest form of malignancy in childhood. The coincidental development of leukaemia in children or adults with haemophilia is extremely rare, although cases of leukaemia and other malignancies have been reported previously in HIV-positive subjects. Of a total of 440 people with haemophilia registered with our society, two were diagnosed with acute leukaemia last year. The development of leukaemia in a subject with haemophilia has previously been reported from our country in 1985, but the negative HIV status of these recent cases is very interesting. The first case involved a 14-year-old boy with moderate haemophilia A, who developed acute lymphoblastic leukaemia (ALL) [French-American-British (FAB) classification L2]. The second subject was a 16-year-old boy who had moderately severe haemophilia A with no previous family history, and developed acute nonlymphocytic (myelomonocytic) leukaemia (FAB-M4). Both patients received conventional chemotherapy and this report discusses the potential problems in management of such cases, including diagnosis and administration of chemotherapy in subjects with a pre-existing haemorrhagic disorder. Extensive cutaneous and mucosal bleeding, as well as bleeds in joints previously affected by haemarthrosis and alterations of haematological values were all initially suggestive of the development of inhibitors against factor VIII, but the appearance of blasts in the peripheral blood and bone marrow led to the definitive diagnosis. The risk of bleeding, due to the combination of both leukaemia and the consequences of the chemotherapy, was overcome by the administration of coagulation factor concentrates (daily initially followed by prophylactic doses after successful induction of remission in both patients). The young patient with ALL is now receiving the maintenance phase of the Children's Cancer Study Group 1961 protocol and is in the 15th month of follow-up, without any complications. The other case relapsed in the seventh month, developing enterobacter sepsis, and died. An important lesson to be learnt from these cases is that the possible diagnosis of leukaemia should not be overlooked in a patient with haemophilia and severe haemorrhagic problems, if the first-line differential diagnosis of inhibitor development against factor VIII (or IX) has been excluded.

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Risk Factors for Pediatric Human Immunodeficiency Virus–Related Malignancy

Pollock

Jenson

Leach

et al. 2003

JAMA

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ALIGNANCY RISK IS INcreased in individuals with human immunodeficiency virus (HIV) infection. 1 The occurrence of Kaposi sarcoma in young male homosexuals was a sentinel indicator of the AIDS epidemic. Pediatric and adolescent AIDS cases with malignancy were first reported in hemophiliacs who had received contaminated blood products. 2-4 For many of these children, malignancy was the first indication of HIV infection. Although the prevalence of HIV infection is lower in children than in adults, cancer incidence rates for HIVinfected children appear disproportionately lower. Prior to the era of highly active antiretroviral therapy, estimates of the incidence of malignancy in HIV-infected children ranged from 0.66 cases per 1000 children per year in the United States 1 to 4.18 per 1000 children per year from an Italian registry 5 while the incidence of malignancy in adults appeared to be much

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Acute childhood leukemia in a patient with hemophilia: First report in Japan

Cited by 6 publications

References 11 publications

Malignancy in patients with haemophilia: a review of the literature

Malignancy in patients with haemophilia: a review of the literature

Two patients with haemophilia and acute leukaemia

Risk Factors for Pediatric Human Immunodeficiency Virus–Related Malignancy

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