Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvae

Olivari, Francisco A.; Hernández, Pedro P.; Allende, Miguel L.

doi:10.1016/j.brainres.2008.09.050

Cited by 142 publications

(115 citation statements)

References 58 publications

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“…While zebrafish do not have a cochlea, they possess auditory and vestibular sensory organs in the ear that consist of sensory HCs surrounded by support cells. HCs of the lateral line are accessible on the surface of the skin and can be easily killed by adding aminoglycoside antibiotics, heavy metals or platinum-containing drugs to fish media [6][7][8]. HCs in the inner ear are not as susceptible to these treatments and sensory HC regeneration in the zebrafish ear is typically induced by killing HCs with a laser or noise stimuli [9][10][11].…”

Section: Cell Biology Of Regenerationmentioning

confidence: 99%

Insights into sensory hair cell regeneration from the zebrafish lateral line

Kniss

Jiang

Piotrowski

2016

Current Opinion in Genetics & Development

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Section: Cell Biology Of Regenerationmentioning

confidence: 99%

Insights into sensory hair cell regeneration from the zebrafish lateral line

Kniss

Jiang

Piotrowski

2016

Current Opinion in Genetics & Development

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“…Antioxidants could protect these cells from the effects of the metal (Manzl et al, 2004;Olivari et al, 2008). An important feature of antioxidant…”

Section: Discussionmentioning

confidence: 99%

Combined Effects of Copper and Temperature on Antioxidant Enzymes in the Black Rockfish Sebastes schlegeli

Min¹,

Baeck²,

Kang³

2014

Fisheries and aquatic sciences

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Copper has been widely used to control algae and pathogens in fish culture ponds. However, its toxic effects on fish depend not only on its concentration in the water but also on the water quality. A laboratory experiment was conducted to assess copper toxicity in the black rockfish Sebastes schlegeli using a panel of antioxidant enzymes, including glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD), at different levels of copper at three water temperatures (WT, 18, 23, 28°C) for 4 days. After exposure to two copper concentrations (100 and 200 μg/L), GSH levels and GST activities increased significantly, depending on WT (P < 0.05) in the liver, gill, and kidney of the black rockfish. GPx and SOD activities decreased significantly with both increasing WT and copper treatment in the organs of black rockfish (P < 0.05). These changes can be seen as initial responses to temperature stress and as a sustained response to copper exposure. This also indicates that GSH and related enzymes activities were sensitive indexes to stress by toxicants such as copper. The present findings suggest that simultaneous stress due to temperature change and copper exposure can accelerate changes in enzymes activities in the black rockfish. This provides another example of synergism between environmental temperature and pollutants, which may have important implications for the survival of fish in polluted environments during seasonal warming and/or global climate change.

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“…Therefore, information on antioxidative mechanisms in the rotifer B. koreanus would be useful for filling the knowledge gap about responses to copper exposure related to other species. Among several oxidative stressors, the toxicity of Cu has been well studied as a potential trigger of reactive oxygen species (ROS) (Olivari et al, 2008;Rhee et al, 2013). The oxidation state can be generated in cells through the reduction reaction of H 2 O 2 , generated by the HarberWeiss and Fenton reaction of Cu cations (Suzuki et al, 1996).…”

Section: Introductionmentioning

confidence: 99%