Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection

Jin, Sierra X.; Juthani, Viral V.

doi:10.1097/ico.0000000000002556

Cited by 66 publications

(83 citation statements)

References 5 publications

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“…However, it is still unclear whether it is caused by the direct SARS-CoV-2 infection to the retina or by thrombosis in the retinal vascular vessels due to the cytokine storm associated with COVID-19. Further, the intense inflammation may drive the severe allograft rejection after corneal transplantation, which required repeat penetrating keratoplasty (PK) [ 27 ]. Chorioretinitis from fungal sepsis has also been reported [ 18 ].…”

Section: Ocular Signs Of Covid-19 Patientsmentioning

confidence: 99%

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies

Kitazawa

Deinhardt‐Emmer

Inomata

et al. 2021

Cells

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem. Although the respiratory system is the main impaired organ, conjunctivitis is one of its common findings. However, it is not yet understood if SARS-CoV-2 can infect the eye and if the ocular surface can be a potential route of SARS-CoV-2 transmissions. Our review focuses on the viral entry mechanisms to give a better understanding of the interaction between SARS-CoV-2 and the eye. We highlighted findings that give evidence for multiple potential receptors of SARS-CoV-2 on the ocular surface. Additionally, we focused on data concerning the detection of viral RNA and its spike protein in the various ocular tissues from patients. However, the expression level seemed to be relatively low compared to the respiratory tissues as a result of a unique environment surrounding the ocular surface and the innate immune response of SARS-CoV-2. Nevertheless, our review suggests the ocular surface as a potential route for SARS-CoV-2 transmission, and as a result of this study we strongly recommend the protection of the eyes for ophthalmologists and patients at risk.

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Section: Ocular Signs Of Covid-19 Patientsmentioning

confidence: 99%

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies

Kitazawa

Deinhardt‐Emmer

Inomata

et al. 2021

Cells

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“…In our knowledge, only one case has been reported so far of acute corneal graft rejection in a COVID-19 patient. [ 5 ]…”

mentioning

confidence: 99%

Acute graft rejection in a COVID-19 patient

Singh

Mathur

2021

Indian Journal of Ophthalmology

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A 32-year-old man with a clear and compact graft following a penetrating keratoplasty 6 years back, developed an episode of acute graft rejection, coinciding with the COVID-19 disease. Subsequent to the infection with the novel coronavirus, he developed symptoms of acute graft rejection concurrent with the development of respiratory distress and peak systemic symptoms. This was the phase of cytokine storm as evidenced by the raised inflammatory markers in his blood tests. Such a case of acute corneal graft rejection coinciding with SARS-CoV-2 infection has been reported only once in the literature and this unique association needs to be researched further.

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“…However, after SARS-CoV-2 infection, she presented graft rejection, treated with methylprednisolone, thymoglobulin, and plasmapheresis. There is a description in eye transplantation that COVID-19 infection can compromise the balance of immunoregulatory responses that allow graft survival, contributing to rejection in individuals infected with SARS-CoV-2 [ 31 ]. Thus, this change in the balance of attenuation of the immune response, such as a reduction in the number of regulatory T cells (Tregs) [ 32 ], may favor direct cardiotoxic action and multiple organ dysfunction.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report

Gozzi-Silva

Benard²,

Alberca³

et al. 2021

TropicalMed

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it is considered a pandemic. SARS-CoV-2 infection can lead to severe pneumonia, acute respiratory distress syndrome (ARDS), septic shock, and/or organ failure. Individuals receiving a heart transplantation (HT) may be at higher risk of adverse outcomes attributable to COVID-19 due to immunosuppressives, as well as concomitant infections that may also influence the prognoses. Herein, we describe the first report of two cases of HT recipients with concomitant infections by SARS-CoV-2, Trypanosoma cruzi, and cytomegalovirus (CMV) dissemination, from the first day of hospitalization due to COVID-19 in the intensive care unit (ICU) until the death of the patients.

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Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection

Cited by 66 publications

References 5 publications

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies

Acute graft rejection in a COVID-19 patient

SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report

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