Acute Coronary Syndrome; Frequency, Contributing Factors and Types in Patient With Typical Chest Pain

Lashari, Naveed Aslam; Lakho, Nadia Irum; Memon, Sarfaraz; Ahmed, Ali; Waseem, Muhammad

doi:10.17957/tpmj/17.3409

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Cardiovascular diseases, especially acute coronary syndromes (ACS), are the leading causes of morbidity and mortality in humans worldwide. According to the World Health Organization (WHO), an estimated 17.5 million people die from cardiovascular diseases annually, and about 42% of these deaths are due to ACS [67,68]. The advances in the study of heart diseases have led to the discovery of a broad range of novel biomarkers associated with cardiovascular risks, including cTnI and cTnT, B-type natriuretic peptide (BNP) and its prohormone NT-proBNP, C-reactive protein (CRP), myeloperoxidase (MPO), lipoprotein-associated phospholipase A2, miRNA, matrix metalloproteinases, and cystatin C [69,70].…”

Section: іма As a Marker For Diseasesmentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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Section: іма As a Marker For Diseasesmentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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“…Similar male predominance was reported Lashari et al as 2.1:1, Shaikh et al as 2.2:1, Adam et al as 1.9:1 and Singh et al as 2:1. 14,15,11,12 In the present study among 128 patients with acute STEMI, 75.8% patients were obese, 50.8% patients were diabetic and 68.0% patients were hypertensive. 56.3% patients were active smokers.…”

Section: Discussionmentioning

confidence: 51%

Frequency of Acute Kidney Injury in Patients Presenting with Acute ST-Elevation Myocardial Infarction and Its Relationship with In-Hospital Mortality

Ali¹,

Umar²,

Pannu³

et al. 2022

PJMHS

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Objective: To determine the frequency of acute kidney injury in patients presenting with acute ST elevation myocardial infarction and to compare the frequency of in-hospital mortality between patients presenting with acute ST elevation myocardial infarction with versus without acute kidney injury at a tertiary care hospital. Design: It was a descriptive case series. Study Settings: Department of Cardiology, Shaikh Zayed Hospital Lahore-Pakistan over a period of 6 months from January 2021 to June 2021. Material and Methods: A total of 128 patients of both genders aged between 18-70 years presenting with in first 12 hours of acute STEMI at emergency ward of cardiology department were included in this descriptive case series study. An informed written consent was taken from all the participants. All these patients were managed as per standard departmental protocols. Renal function was assessed within 30 minutes of presentation and then after 72 hours of admission and acute kidney injury was labelled if there was ≥0.5 mg/dl increase in serum creatinine level from baseline. These patients were followed till discharge and death of the patient during hospital stay was noted. It was then compared between patients with versus without acute kidney injury. Results: The patients had mean age of 53.8±11.3 years. There were 86 (67.2%) males and 42 (32.8%) females with a male to female ratio of 2.1:1. 97 (75.8%) patients were obese, 65 (50.8%) patients were diabetic and 87 (68.0%) patients were hypertensive. 72 (56.3%) patients were active smokers. 25 (19.5%) patients with acute STEMI developed acute kidney injury while 10 (7.8%) patients died during hospital stay. The frequency of in-hospital mortality was significantly higher in acute STEMI patients with AKI as compared to those without AKI (24.0% vs. 3.9%; p-value=0.004). When compared similar difference was noted in in-hospital mortality between acute STEMI patients with versus without AKI across various subgroups based on age, gender, BMI, diabetes, hypertension, smoking, ASA status, thrombolysis and need for PCI. Conclusion: A substantial proportion of patients presenting with acute ST-segment elevation myocardial infarction developed acute kidney injury that was associated with increased frequency of mortality among such patients which warrants routine monitoring of renal function among patients presenting with acute ST-segment elevation myocardial infarction and consideration of cases positive of AKI at higher risk of mortality so that risk stratification and anticipated management may improve the outcome of such patients in future practice. Keywords: Acute ST Elevation Myocardial Infarction, Acute Kidney Injury, In-Hospital Mortality.

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“…The mean age of the patients was 48.7+13.5years. 11 Another study demonstrated that 9.2% patients were up to 40 years old, 46.7% were 41-60 years old and 44.1% were more than 60 years old which shows that disease was prevalent among mainstream of the patients who were more than 40 years old. 12 The ECG is one of the medical tests that discover heart problems through measuring electrical activity generated by the heart when it contracts.…”

Section: Discussionmentioning

confidence: 97%

Assessment of plasma MPO and cTnI levels in patients with cardiac chest pain of 4-6 hours duration.

Riaz

2022

TPMJ

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Objective: To assess the plasma MPO and cTnI levels in patients with cardiac chest pain of 4-6 hours duration. As cardiac troponins rise late almost 6-8 hours after the onset of myocardial infarction, another marker is needed to make earlier diagnosis and in those where ECG findings are nonspecific. Study Design: Cross Sectional study. Setting: Emergency Department and Central Laboratory of Punjab Institute of Cardiology (PIC) Lahore. Pathology Department and Central Laboratory of Postgraduate Medical Institute (PGMI)/ Lahore General Hospital (LGH)/ Ameer ud Din Medical College (AMC) Lahore. Period: January 2018 to December 2018. Material & Methods: Eighty subjects were selected who presented with typical chest pain. Two samples from each subject were taken, first sample for MPO within two hours and the second sample for cTnI four to six hours after the start of chest pain. MPO samples were taken in ethylenediaminetetraacetic acid (EDTA) and cTnI samples in heparin tubes. Results: Out of 80 patients, the mean age was 56.40 + 11.39 years. Only one (1.2%) patient was found positive (MPO > 5 u/ml) and the mean MPO was 2.10 + 1.35 u/ml. Among these patients, 25.0% had 0.04-0.3 ng/ml (suspected ischemia) while majority 65.0% patients had cTI >0.3 ng/ml (positive) and mean cTnI was 5.42 + 1.16 ng/ml. Conclusion: MPO samples taken within two hours of chest pain, 1.2% patients were positive. Tests carried out for cTnI taken four to six hours after chest pain, 65.0% patients were positive.

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Acute Coronary Syndrome; Frequency, Contributing Factors and Types in Patient With Typical Chest Pain

Cited by 6 publications

References 14 publications

Ischemia-Modified Albumin: Origins and Clinical Implications

Ischemia-Modified Albumin: Origins and Clinical Implications

Frequency of Acute Kidney Injury in Patients Presenting with Acute ST-Elevation Myocardial Infarction and Its Relationship with In-Hospital Mortality

Assessment of plasma MPO and cTnI levels in patients with cardiac chest pain of 4-6 hours duration.

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