Acute dissecting thoracic aortic aneurysm presenting with stroke, consumptive coagulopathy, and gastrointestinal hemorrhage

Sadhwani, Deepti; O’Mara, Karen

doi:10.1016/s0736-4679(99)00051-7

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Other rare presentations of aortic dissections include unilateral lower extremity numbness, 5 stroke, consumptive coagulopathy, and gastrointestinal haemorrhage, 8 and aorto-right atrial fistula. 9 All patients in whom aortic dissection is suspected, even if the index of suspicion is very low, should undergo one of the available diagnostic procedures: aortography, computed tomography, magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

Collapse, hoarseness of the voice and swelling and bruising of the neck: an unusual presentation of thoracic aortic dissection

Al-Hity¹

2001

Emergency Medicine Journal

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A 66 year old woman presented to the accident and emergency department with history of collapse, hoarseness of the voice, and swelling and bruising of the neck. The diagnosis was not initially obvious because of the absence of chest pain. The findings on the radiograph of the soft tissue of the neck and chest radiograph suggested the need for computed tomography of the neck and chest. This confirmed the cervical haematoma and typical signs of aortic dissection. This unusual presentation of thoracic aortic dissection is discussed below.

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Section: Discussionmentioning

confidence: 99%

Collapse, hoarseness of the voice and swelling and bruising of the neck: an unusual presentation of thoracic aortic dissection

Al-Hity¹

2001

Emergency Medicine Journal

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“…Administration of clotting factor concentrates and definitive surgical repair were the main treatment approaches. In contrast, the use of low-dose heparin to control the consumptive coagulopathy in a bleeding patient with DIC remains controversial (20).…”

Section: Discussionmentioning

confidence: 99%

Relevant bleeding diathesis due to acquired factor XIII deficiency

Janning¹,

Holstein²,

Spath³

et al. 2013

Hamostaseologie

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“…Approximately 80% of strokes are ischemic in origin [7]. Ischemic stroke has been linked to many risk factors, including alcohol abuse [8], coagulopathy (blood clotting disorder) [9], diabetes mellitus (DM) [10], fibromuscular dysplasia [11], family or personal history of stroke [12], high cholesterol [13], brain tumor [14], smoking [15], hypertension (HTN) [16], hyperlipidemia [17], and metabolic syndrome [18].…”

Section: Introductionmentioning

confidence: 99%

“…PAI-1, also known as SERPINE1, is located on the seventh human chromosome (7q21. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. PAI-1 is the main inhibitor of tissue plasminogen activator and urokinase [24], which are responsible for converting plasminogen to the fibrinolysis enzyme plasmin [25].…”

Section: Introductionmentioning

confidence: 99%

Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort

Choi

Cho

et al. 2023

IJMS

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Stroke is the second leading cause of death in the world. Approximately 80% of strokes are ischemic in origin. Many risk factors have been linked to stroke, including an increased level of plasminogen activator inhibitor-1 (PAI-1). PAI-1 levels increase and remain elevated in blood during the acute phase of ischemic stroke, which can impair fibrinolytic activity, leading to coronary artery disease and arterial thrombotic disorders. Here, we present a case-control study of 574 stroke patients and 425 controls seen for routine health examination or treatment for nonspecific dizziness, nonorganic headache, or anxiety for positive family history of stroke at the Bundang Medical Center in South Korea. Polymorphisms in PAI-1 were identified by polymerase chain reaction/restriction fragment length polymorphism analysis using genomic DNA. Specifically, three variations (−675 4G>5G, 10692T>C, and 12068G>A) were linked to a higher overall prevalence of stroke as well as a higher prevalence of certain stroke subtypes. Haplotype analyses also revealed combinations of these variations (−844G>A, −675 4G>5G, 43G>A, 9785A>G, 10692T>C, 11053T>G, and 12068G>A) that were significantly associated with a higher prevalence of ischemic stroke. To the best of our knowledge, this is the first strong evidence that polymorphic sites in PAI-1 promoter and 3′-UTR regions are associated with higher ischemic stroke risk. Furthermore, the PAI-1 genotypes and haplotypes identified here have potential as clinical biomarkers of ischemic stroke and could improve the prognosis and future management of stroke patients.

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Acute dissecting thoracic aortic aneurysm presenting with stroke, consumptive coagulopathy, and gastrointestinal hemorrhage

Cited by 7 publications

References 17 publications

Collapse, hoarseness of the voice and swelling and bruising of the neck: an unusual presentation of thoracic aortic dissection

Collapse, hoarseness of the voice and swelling and bruising of the neck: an unusual presentation of thoracic aortic dissection

Relevant bleeding diathesis due to acquired factor XIII deficiency

Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort

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