Acute effect of microdissection testicular sperm extraction on blood total testosterone and luteinising hormone levels

Sertkaya, Zülfü; Tokuç, Emre; Özkaya, Fatih; Ertaş, Kemal; Kutluhan, Musab Ali; Çulha, Mehmet Gökhan

doi:10.1111/and.13655

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…P < 0.05 was considered as significant levels. After the TESE procedure, a significant decrease in testosterone levels and a significant increase in LH levels were shown at 24 h and at one week postoperatively [29]. A review of the literature published in 2021 shows that the TESE procedure can lead to structural disturbances of the testicular tissue leading to an alteration of the vascularization and can result in androgen deficiency [30].…”

Section: Discussionmentioning

confidence: 99%

For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship

Bendayan

Sais

Fathallah

et al. 2022

Basic Clin. Androl.

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Background A very small number of studies have indicated that azoospermia or negative testicular sperm extraction (TESE) outcomes are linked to depression or erectile dysfunction. However, the data are often weak, conflicting and gathered with non-validated questionnaires. Hence, we performed a cross-sectional study of 44 men with non-obstructive azoospermia. Levels of self-esteem and the quality of the couple’s sex life and overall relationship were assessed with validated questionnaires before and after the TESE procedure as a function of the TESE outcome. Results A positive TESE outcome (n = 24) was associated with a statistically significant increase in self-esteem (particularly with regard to family aspects), sexual health and couples’ adjustment quality. In contrast, a negative TESE outcome (n = 20) was associated with statistically significant decreases in self-esteem, erectile function, intercourse satisfaction, orgasmic function, couples’ adjustment quality and all aspects of the couple’s relationship (consensus, cohesion, satisfaction and affection). Conclusion For men with non-obstructive azoospermia (NOA), negative TESE outcomes may have a negative impact on self-esteem and the quality of the couple’s sex life and overall relationship. This should be borne in mind when counselling men with NOA and their partners to (ideally) help them to cope with and decrease the harmful impacts of azoospermia and negative TESE.

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Section: Discussionmentioning

confidence: 99%

For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship

Bendayan

Sais

Fathallah

et al. 2022

Basic Clin. Androl.

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“…These abnormal Leydig cells are more vulnerable to further disruption after a TESE procedure, leading to more profound, prolonged, and even permanent hypogonadism in some cases. Furthermore, it has been implied that it may have a less responsive hypothalamic-pituitary-testicular axis [ 7 , 27 , 30 ].…”

Section: Complicationsmentioning

confidence: 99%

Endocrine Follow-Up of Men with Non-Obstructive Azoospermia Following Testicular Sperm Extraction

Billa

Kanakis

Goulis

2021

JCM

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Testicular sperm extraction (TESE) is a surgical procedure which, combined with intracytoplasmic sperm injection, constitutes the main treatment for achieving biological parenthood for patients with infertility due to non-obstructive azoospermia (NOA). Although it is effective, TESE procedures might cause structural testicular damage leading to Leydig cell dysfunction and, consequently, temporary or even permanent hypogonadism with long-term health consequences. To a lesser extent, the same complications have been reported for microdissection TESE, which is considered less invasive. The resulting hypogonadism is more profound and of longer duration in patients with Klinefelter syndrome compared with other NOA causes. Most studies on serum follicle-stimulating hormone and luteinizing hormone concentrations negatively correlate with total testosterone concentrations, which depends on the underlying histology. As hypogonadism is usually temporary, and a watchful waiting approach for about 12 months postoperative is suggested. In cases where replacement therapy with testosterone is indicated, temporary discontinuation of treatment may promote the expected recovery of testosterone secretion and revise the decision for long-term treatment.

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“…Although micro-TESE has contributed to sperm retrieval, yielding satisfactory outcomes of intracytoplasmic sperm injection (ICSI) in some patients with INOA (Refs 13–16), its low surgical success rate and associated iatrogenic testicular trauma are undeniable drawbacks to this invasive approach (Refs 17–20). Therefore, accurate preoperative predictive models to estimate the probability of surgically retrieving sperm using micro-TESE are of great significance.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive molecular biomarkers for predicting outcomes of micro-TESE in patients with idiopathic non-obstructive azoospermia

Tang

et al. 2022

Expert Rev. Mol. Med.

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Non-obstructive azoospermia (NOA), the most severe type of male infertility, affects approximately 1% of men worldwide. However, the aetiology of most NOA cases is not definite, that is defined as idiopathic NOA (INOA), posing a clinical conundrum worldwide. Most of these patients must receive donor sperm treatment until the emergence of microdissection testicular sperm extraction (micro-TESE). Although this procedure has recently become a promising treatment for INOA, the low sperm retrieval rate and testicular trauma have prompted us to explore appropriate non-invasive molecular biomarkers to predict the outcomes of sperm recovery preoperatively. Previous studies have identified a spectrum of biomarkers to address this challenging issue at various levels in different tissues, such as DNAs, RNAs, protein and steroid levels in the blood and seminal fluid. To better understand and assess the predictive values of diverse molecular biomarkers from different tissues on the outcome of sperm retrieval by micro-TESE in patients with INOA, we summarised recent findings and discussed the potential applications of these methods. The ultimate goal of this study was to provide references for further studies and clinical management.

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Acute effect of microdissection testicular sperm extraction on blood total testosterone and luteinising hormone levels

Cited by 5 publications

References 19 publications

For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship

For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship

Endocrine Follow-Up of Men with Non-Obstructive Azoospermia Following Testicular Sperm Extraction

Non-invasive molecular biomarkers for predicting outcomes of micro-TESE in patients with idiopathic non-obstructive azoospermia

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