Acute effect of vaporized Cannabis on sleep and electrocortical activity

Mondino, Alejandra; Cavelli, Matías; González, Joaquín; Santana, Noelia; Castro-Zaballa, Santiago; Mechoso, Burix; Bracesco, Nélson; Fernández, Santiago; García-Carnelli, Carlos; Castro, María José; Umpiérrez, Eleuterio; Murillo-Rodrı́guez, Eric; Torterolo, Pablo; Falconi, Atilio

doi:10.1016/j.pbb.2019.02.012

Cited by 20 publications

(20 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The majority of recent studies have focused on understanding the individual contributions of either THC or CBD. Indeed, several recent studies have used cannabis extracts (Mondino et al, 2019 ), purified THC (Kimura et al, 2019 ), or CBD (Murillo-Rodriguez et al, 2006b , 2008b , 2011a , 2014 ) to study how acute administration of these compounds affects sleep and sleep-pathologies including sleep apnea (Carley et al, 2002 ; Calik et al, 2014 ) and depression increased PS (Hsiao et al, 2012 ). This increased productivity in animal model studies of phytocannabinoid actions is likely to accelerate and will provide much-needed neurobiological information about the mechanisms involved in the actions of these substances.…”

Section: Phytocannabinoids and Sleep In Rodentsmentioning

confidence: 99%

Cannabinoids, Endocannabinoids and Sleep

Kesner

Lovinger

2020

Front. Mol. Neurosci.

103

View full text Add to dashboard Cite

Sleep is a vital function of the nervous system that contributes to brain and bodily homeostasis, energy levels, cognitive ability, and other key functions of a variety of organisms. Dysfunctional sleep induces neural problems and is a key part of almost all human psychiatric disorders including substance abuse disorders. The hypnotic effects of cannabis have long been known and there is increasing use of phytocannabinoids and other formulations as sleep aids. Thus, it is crucial to gain a better understanding of the neurobiological basis of cannabis drug effects on sleep, as well as the role of the endogenous cannabinoid system in sleep physiology. In this review article, we summarize the current state of knowledge concerning sleep-related endogenous cannabinoid function derived from research on humans and rodent models. We also review information on acute and chronic cannabinoid drug effects on sleep in these organisms, and molecular mechanisms that may contribute to these effects. We point out the potential benefits of acute cannabinoids for sleep improvement, but also the potential sleep-disruptive effects of withdrawal following chronic cannabinoid drug use. Prescriptions for future research in this burgeoning field are also provided.

show abstract

Section: Phytocannabinoids and Sleep In Rodentsmentioning

confidence: 99%

Cannabinoids, Endocannabinoids and Sleep

Kesner

Lovinger

2020

Front. Mol. Neurosci.

103

View full text Add to dashboard Cite

show abstract

“…Emerging research has focused on the benefits of cannabis for treating neuropathic pain (Lee et al., 2018), nausea and vomiting (Phillips et al., 2016; Whiting et al., 2015), poor appetite and anxiety, in cancer survivors (Anderson et al., 2019; Bruce et al., 2019). Research also suggests that cannabis may have positive effects on improving both self‐reported sleep quality and non‐rapid eye movement sleep (Lee et al., 2018; Mondino et al., 2019). Reviews suggested that cannabis users are more likely to engage in physical activities and experience enhanced recovery after exercise (YorkWilliams et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Associations among marijuana use, health‐related quality of life, exercise, depression and sleep in cancer survivors

Gilmer

Starkweather

et al. 2021

Journal of Advanced Nursing

View full text Add to dashboard Cite

Aims To assess associations among cannabis use, health‐related quality of life, exercise, depression and sleep among a nationally representative sample of US adults living with cancer. Design A cross‐sectional correlational study. Methods We used survey data from the 2016–2018 Behavioral Risk Factor Surveillance System. Analyses were considered for sample weights and the complex designs. Logistic regression was performed to assess associations among cannabis use (0, 1–19, vs. 20–30 [frequent] days), health‐related quality of life (0–13 vs. ≥14 mentally or physically unhealthy days in the past 30 days; 0–13 vs. ≥14 functionally limited days), exercise, depression, and sleep after accounting for covariates. Reason for cannabis use (medical vs. non‐medical) was also assessed. Results Frequent users had significantly more physically unhealthy days (adjusted odds ratio [OR]: 1.79, 95% CI: 1.28–2.51, p < .01) and reported ≥ 14 mentally unhealthy days (adjusted OR: 2.43, 95% CI: 1.78–3.32, p < .001) and depression (adjusted OR: 2.65, 95% CI: 1.97–3.57, p < .001) compared with non‐users. A positive relationship between frequency of cannabis use and depression existed only among non‐medical cannabis users. Conclusion Cancer survivors using cannabis frequently (20 days+ in the past month) had poorer mental health‐related quality of life. The reason for cannabis use as well as frequency of use may be important considerations in predicting depression. Impact This is the first study that evaluates the associations among cannabis use, the purpose of cannabis use, HRQoL, exercise, depression and sleep in a nationally representative sample of US adults living with cancer. Frequent cannabis users are likely vulnerable to poorer mental health‐related quality of life and depression, and non‐medical cannabis use in frequent users was associated with depression. Given expanding medical cannabis legalization, these findings warrant further attention so that this information can be used by people living with cancer in decision‐making for symptom self‐management.

show abstract

“…REM sleep was defined as low voltage fast frontal waves, a regular theta rhythm in parietal and occipital cortices, and a silent EMG except for occasional twitching. In order to analyze power spectrum (in each channel) and coherence (between pairs of iEEG channels or derivations) we used procedures similar to those done in our previous studies (Cavelli et al, 2015;Cavelli et al, 2018;Mondino et al, 2019). The maximum number of non-transitional and artifact-free periods of 30 seconds was selected during each behavioral state to determine the mean power and coherence for each rat.…”

Section: Discussionmentioning

confidence: 99%

“…The analysis of the data was performed for the classically defined frequency band in rodents: delta, 1-4 Hz; theta, 5-9 Hz; sigma, 10-15 Hz; beta, 16-30 Hz; low gamma (LG), 31-48 Hz; high gamma (HG) 52-95 Hz; and high frequency oscillations (HFO), 105-200 Hz (Cavelli et al, 2018;Mondino et al, 2019). Frequencies around 50 and 100 Hz were not analyzed to avoid alternating current artifacts.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Power and coherence in the EEG of the rat: impact of behavioral states, cortical area, lateralization and light/dark phases

Mondino

Cavelli

González

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined by the function of the thalamo-cortical system. Thalamo-cortical activity can be examined by means of the intra-cranial electroencephalogram (iEEG). With the purpose to study in depth the basal activity of the iEEG in adult rats, we analyzed the spectral power and coherence of the iEEG during W and sleep in the paleocortex (olfactory bulb), as well as in motor, somatosensory and visual neocortical areas. We also analyzed the laterality (right Vs. left hemispheres) of the signals, as well as the iEEG in function of the light and dark phases. We found that the iEEG power and coherence of the whole spectrum were largely affected by behavioral states and were highly dependent on the cortical areas recorded. We also determined that there are night/day differences in power and coherence during sleep, but not in W. Finally, while we did not find right/left differences in power either in W or sleep, we observed that during REM sleep intra-hemispheric coherence differs between both hemispheres. We conclude that the iEEG dynamics is highly dependent on the cortical area and behavioral states. We also determine that there are light/dark phases disparities in the iEEG that emerge during sleep, and that intra-hemispheric connectivity differs between both hemispheres only during REM sleep.

show abstract

Acute effect of vaporized Cannabis on sleep and electrocortical activity

Cited by 20 publications

References 80 publications

Cannabinoids, Endocannabinoids and Sleep

Cannabinoids, Endocannabinoids and Sleep

Associations among marijuana use, health‐related quality of life, exercise, depression and sleep in cancer survivors

Power and coherence in the EEG of the rat: impact of behavioral states, cortical area, lateralization and light/dark phases

Contact Info

Product

Resources

About