Acute effects of alprazolam on risky decision making in humans

Lane, Scott D.; Tcheremissine, Oleg V; Lieving, Lori M.; Nouvion, Sylvain O.; Cherek, Don R.

doi:10.1007/s00213-005-2265-8

Cited by 40 publications

(36 citation statements)

References 40 publications

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“…This includes demonstrations that manipulation of serotonergic (Rogers et al, 1999a(Rogers et al, , 2003, catecholamine (Rogers et al, 2004;Scarna et al, 2005) and GABAergic activity (Deakin et al, 2004;Lane et al, 2005a) can influence laboratory models of decision-making. However, at the current time, little is known about the importance of cannabinoid activity in decision-making despite the preponderance of CB 1 receptors within corticolimbic circuitry (Herkenham et al, 1990) and their interactions with other neuromodulatory systems (Ameri, 1999;Tanda et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Low Doses of Δ-9 Tetrahydrocannabinol on Reinforcement Processing in the Risky Decision-Making of Young Healthy Adults

Rogers

Wakeley

Robson

et al. 2006

Neuropsychopharmacol

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Research suggests that risky decision-making is sensitive to neuromodulatory influences acting upon corticolimbic circuitry. However, while other evidence attests to effects of D-9 tetrahydrocannabinol (THC) on the activity of reward pathways, relatively little is known about the possible involvement of cannabinoid activity in risky choice. In this experiment, we examined the effects of a single sublingual 5 mg dose of THC on a test of risky decision-making (requiring choices between simultaneously presented gambles differing in their magnitude of gains, magnitude of losses and the probability with which these outcomes were delivered). Tests of non-normative decision-making involving risk-aversion when deciding between gains and risk-seeking choices when deciding between losses were also included. In all, 15 healthy adults were administered 5 mg THC and placebo in a double-blind, placebo-controlled, within-subject, crossover design. THC had three principal effects relative to placebo: (i) THC reduced choice of gambles with variable gains and losses, but increased choice of gambles with zero-expected value; (ii) THC reduced participants' attention towards losses when the probability of winning was low (and the probability of losing was high); and (iii) THC speeded participants' responses to gambles with large compared to small potential gains. These results suggest that THC mediates specific motivational processes and the processing of reinforcement cues during risky choice, perhaps reflecting altered CB 1 receptor or catecholamine activity within corticolimbic pathways.

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Section: Introductionmentioning

confidence: 99%

The Effects of Low Doses of Δ-9 Tetrahydrocannabinol on Reinforcement Processing in the Risky Decision-Making of Young Healthy Adults

Rogers

Wakeley

Robson

et al. 2006

Neuropsychopharmacol

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“…Asimismo, algunos estudios en consumidores de esta sustancia han encontrado alteraciones en la impulsividad indicando comportamientos desinhibidos (Michel y Lang, 2003), toma de decisiones impulsivas (Dassanayake et al, 2012;Lane, Tcheremissine, Lieving, Nouvion, y Cherek, 2005), y déficits en la inhibición de respuesta (Acheson, Reynolds, Richards, y de Wit, 2006). Distintos modelos teóricos sobre adicción han señala-do la impulsividad como un marcador de vulnerabilidad de gran relevancia en la explicación de los procesos adictivos, tanto para explicar el inicio como el mantenimiento del consumo de drogas (Adan, 2002, Arce y Santisteban, 2006Cano-Cervantes, Araque-Serrano, y Cándido-Ortiz, 2011;Cortés-Tomás, Giménez-Costa, Motos-Sellés, y Cadaveira-Mahía, 2014;Gullo, Loxton, y Dawe, 2014;Navas, Torres, Cándido, y Perales, 2014;Pattij y De Vries, 2013).…”

Section: Impulsivity In Men With Prescription Of Benzodiazepines and unclassified

Impulsividad en varones con prescripción de benzodiacepinas y metadona en prisión

Moreno-Ramos¹,

Fernández-Serrano²,

Pérez-Garcı́a

et al. 2016

Adicciones

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Benzodiazepines and methadone use has been associated with various neuropsychological impairments. However, to the best of our knowledge, no studies have been carried out on the effect of these substances (either separately or combined) on impulsive personality, including studies in prisoners. The aim of this study is to examine the impulsive personality of a sample of 134 male prisoners using the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (Torrubia, Avila, Molto, & Caseras, 2001) and the UPPS-P Scale . Some of these were methadone users, methadone and benzodiazepines users, polydrug users in abstinence and non-dependent drug users. The results showed that drug users have greater sensitivity to reward, positive urgency, negative urgency and sensation seeking than non-dependent users.Methadone users showed more sensitivity to punishment and lack of perseverance with respect to other users. No differences were found between methadone+benzodiazepines users and other groups. The secondary aim is to examine which impulsive personality dimensions are related to the two motivational systems proposed by Gray (BIS-BAS) using exploratory factor analysis. Results showed two different components. One component was defined by the subscales sensitivity to reinforcement, positive urgency, negative urgency and sensation seeking. The second component was defined by the subscales sensitivity to punishment, lack of perseverance and lack of premeditation.

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“…Deakin et al [2004] showed that a dose of the benzodiazepine val-520 ium increased the number of points wagered in a risktaking task in only those trials with the lowest odds of winning but the highest potential payoff. Lane et al [2005b] found that administration of the benzodiazepine alprazolam produced increased selection of a 525 risky option under laboratory conditions. The strength of subjects' risk-seeking personality traits may be predictive of how drugs affect their risk-taking behavior (Lane et al [2005b]).…”

Section: Hbhf_02_237633mentioning

confidence: 99%

“…Lane et al [2005b] found that administration of the benzodiazepine alprazolam produced increased selection of a 525 risky option under laboratory conditions. The strength of subjects' risk-seeking personality traits may be predictive of how drugs affect their risk-taking behavior (Lane et al [2005b]). …”

Section: Hbhf_02_237633mentioning

confidence: 99%

Affect and Financial Decision-Making: How Neuroscience Can Inform Market Participants

Peterson¹

2007

Journal of Behavioral Finance

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Acute effects of alprazolam on risky decision making in humans

Cited by 40 publications

References 40 publications

The Effects of Low Doses of Δ-9 Tetrahydrocannabinol on Reinforcement Processing in the Risky Decision-Making of Young Healthy Adults

The Effects of Low Doses of Δ-9 Tetrahydrocannabinol on Reinforcement Processing in the Risky Decision-Making of Young Healthy Adults

Impulsividad en varones con prescripción de benzodiacepinas y metadona en prisión

Affect and Financial Decision-Making: How Neuroscience Can Inform Market Participants

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