Acute effects of d -amphetamine during the follicular and luteal phases of the menstrual cycle in women

Justice, Angela; Wit, Harriet de

doi:10.1007/s002130051033

Cited by 181 publications

(139 citation statements)

References 15 publications

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“…Females display higher levels of wheel running and are more affected by the disruptive properties of wheel running on other home cage behaviours and circadian rhythmicity. These findings are in line with our hypothesis and supported by evidence from studies that found an influence of hormonal fluctuations during the menstrual cycle on the enhanced behavioural response to rewarding substances in female rats [10] and humans [15].…”

Section: Gender Difference In Wheel Runningsupporting

confidence: 92%

“…Both animal and human studies report gender differences in the responses to a rewarding substance and a possible influence of the menstrual cycle on the enhanced response in females [10,15]. First aim of the present study was therefore to investigate wheel running in male C57BL/6 mice to detect a possible gender difference when comparing the results of the present study with male C57BL/6 mice to our earlier findings in female C57BL/6.…”

Section: Introductionmentioning

confidence: 75%

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Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Visser

Bos

Stoker

et al. 2007

Behavioural Brain Research

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Recent studies suggest running wheel activity to be naturally rewarding and reinforcing; considering the shared neuro-behavioural characteristics with drug-induced reward situations, wheel running behaviour gains interest as a tool to study mechanisms underlying reward-sensitivity. Previously, we showed that wheel running has the potential to disrupt the daily organization of home cage behaviour in female C57BL/6 [de Visser L, van den Bos R, Spruijt BM. Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion. Behav Brain Res 2005;160:382-8]. In the present study, we investigated the effects of novelty-induced stress on wheel running and its impact on home cage behaviour in male C57BL/6 and DBA/2 mice. Our aim was to determine whether wheel running may be used as a tool to study both genetic and environmentally induced differences in sensitivity to rewarding behaviour in mice. One group of male mice was placed in an automated home cage observation system for 2 weeks with a wheel integrated in the cage. A second group of mice was allowed to habituate to this cage for 1 week before a running wheel was introduced. Results showed a pronounced sensitising effect of novelty on the level of wheel running in C57Bl/6 mice but not in DBA mice. Overall levels of wheel running were higher in DBA/2 mice. Furthermore, wheel running affected circadian rhythmicity in DBA/2 mice but not in C57BL/6 mice.From these findings we tentatively suggest that wheel running behaviour could serve as a tool to study the interaction between genetic and environmental factors in sensitivity to rewarding behaviour in mice. As it is displayed spontaneously and easy to monitor, wheel running may be well suitable to be included in high-throughput phenotyping assays.

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Section: Gender Difference In Wheel Runningsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 75%

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Visser

Bos

Stoker

et al. 2007

Behavioural Brain Research

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“…cocaine than males. Further, several studies have shown that ratings such as 'High' are increased more during the follicular phase than the luteal phase in women after stimulant administration (Justice and de Wit, 1999;Sofuoglu et al, 1999;Evans et al, 2002). Taken together, these data indicate that there are sex differences in the behavioral response to stimulants, and that these differences are related to ovarian hormone levels.…”

Section: Introductionmentioning

confidence: 61%

Pharmacokinetics of Intravenous Cocaine Across the Menstrual Cycle in Rhesus Monkeys

Evans

Foltin

2004

Neuropsychopharmacol

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Several studies in rodents suggest that there are sex differences in response to cocaine that are related to fluctuations in the ovarian hormones of females. Female rhesus monkeys have menstrual cycles that are remarkably similar to human menstrual cycles in both duration and hormonal variations. Therefore, data obtained in monkeys should be an ideal model for assessing the effects of cocaine across the menstrual cycle in humans. The present study assessed the acute effects of intravenous cocaine (0, 0.25, 0.50, and 1.00 mg/kg) in five female rhesus monkeys during four phases of the menstrual cycle: menses, midfollicular, periovulatory, and midluteal. To reduce the effects of stress that can occur from sedation, all animals were trained to enter primate chairs so that repeated blood samples could be obtained in awake animals. Hormone levels for estradiol and progesterone were measured each session before cocaine administration. Cocaine and cocaine metabolite plasma levels were measured at 5, 15, 30, 45, 60, and 90 min after cocaine administration. Similarly, levels of luteinizing hormone (LH) were measured before, 15, 30, 45, 60, and 90 min after cocaine administration. Within 5 min of cocaine administration, cocaine plasma levels peaked and dose-dependent behavioral changes (ie increased motor activity, mydriasis, and refusal of treats) were observed. These effects typically resolved in 15-30 min. There were few differences in the pharmacokinetic profile of cocaine across the menstrual cycle. However, the cocaine metabolites, BZE and EME, did vary across the menstrual cycle, with both being increased in the luteal phase, particularly following the highest dose of cocaine. In addition, unlike previous studies, cocaine did not produce consistent increases in LH levels. Rather, the change in LH levels depended on menstrual cycle phase and cocaine dose. In summary, there is little evidence that the pharmacokinetics of cocaine vary as a function of menstrual cycle phase.

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“…For example, females report a greater subjective response to both cocaine (Evans et al, 2002;Sofuoglu et al, 1999) and amphetamine (AMPH) (Justice and de Wit, 1999;White et al, 2002) in the follicular phase of the menstrual cycle, when estradiol is predominant, as compared to the luteal phase, when both estradiol and progesterone are elevated. Furthermore, AMPH-induced subjective effects are positively correlated with salivary estradiol levels and negatively correlated with progesterone levels (White et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Jackson

Robinson

Becker

2005

Neuropsychopharmacol

285

272

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Men and women differ in their response to cocaine, and a woman's response varies with the menstrual cycle. For example, women have greater subjective responses to cocaine in the follicular phase of the menstrual cycle when estradiol is predominant, than they do during the luteal phase when both estradiol and progesterone are elevated. Similarly, female rats show significantly more cocaine-induced locomotor behavior and cocaine self-administration during behavioral estrus, shortly after estradiol peaks, than during other stages of the cycle, and estradiol administration to ovariectomized (OVX) females enhances the acquisition of cocaine self-administration. The purpose of this study was to expand upon these findings by studying the effects of progesterone administration to females, and estradiol administration to males, on acquisition of cocaine self-administration. We report here that there are both sex differences in and effects of circulating ovarian hormones on acquisition of cocaine self-administration. We demonstrate that although estradiol administration enhances acquisition of cocaine self-administration in OVX female rats, concurrent administration of progesterone with estradiol inhibits this effect of estradiol. In a separate experiment, we demonstrate that estradiol administration does not enhance acquisition of cocaine self-administration in castrated male rats. We conclude that (1) there is a sex difference in the effects of estradiol on cocaine selfadministration: it facilitates acquisition in female, but not male rats; and that (2) in females concurrent progesterone treatment counteracts the facilitory effect of estradiol on cocaine self-administration.

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Acute effects of d -amphetamine during the follicular and luteal phases of the menstrual cycle in women

Abstract: These findings suggest that estrogen may enhance the subjective responses to a stimulant drug in women, but that this effect may be masked in the presence of progesterone.

Cited by 181 publications

References 15 publications

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Pharmacokinetics of Intravenous Cocaine Across the Menstrual Cycle in Rhesus Monkeys

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

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