Acute effects of deep brain stimulation on brain function in obsessive–compulsive disorder

Bangel, Katrin A.; Bais, Melisse; Eijsker, Nadine; Schuurman, P. Richard; Munckhof, Pepijn van den; Figee, Martijn; Smit, Dirk J.A.; Denys, Damiaan

doi:10.1016/j.clinph.2022.12.012

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Apart from frequency, the LFP signals contain multiple dimensions, including waveform, power, phase, entropy, and coupling ( 14 ); developing advanced algorithms could help retrieve more pertinent information ( 44 ). Secondly, LFP oscillations were recorded in different timelines, such as intraoperatively and before or after DBS stimulation ( 19 , 45 ); therefore, comparisons could not be performed, more studies with recording in the same timeline are needed in the future. Finally, because of the small sample sizes of patients ( Tables 1 , 2 ), more studies are needed to confirm the validity and reliability of LFPs.…”

Section: Discussionmentioning

confidence: 99%

Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review

Zhang

Xiong

et al. 2023

Front. Psychiatry

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ObjectivesThe purpose of this paper is to provide a mini-review covering the recent progress in human and animal studies on local field potentials (LFPs) of major depressive disorder (MDD) and obsessive-compulsive disorder (OCD).Materials and methodsPubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the LFPs on OCD or MDD, (2) published in English, and (3) human or animal studies. Exclusion criteria were (1) review or meta-analysis or other literature types without original data and (2) conference abstract without full text. Descriptive synthesis of data was performed.ResultsEight studies on LFPs of OCD containing 22 patients and 32 rats were included: seven were observational studies with no controls, and one animal study included a randomized and controlled phase. Ten studies on LFPs of MDD containing 71 patients and 52 rats were included: seven were observational studies with no controls, one study with control, and two animal studies included a randomized and controlled phase.ConclusionThe available studies revealed that different frequency bands were associated with specific symptoms. Low frequency activity seemed to be closely related to OCD symptoms, whereas LFPs findings in patients with MDD were more complicated. However, limitations of recent studies restrict the drawing of definite conclusions. Combined with other measures such as Electroencephalogram, Electrocorticography, or Magnetoencephalography and long-term recordings in various physiological states (rest state, sleep state, task state) could help to improve the understanding of potential mechanisms.

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Section: Discussionmentioning

confidence: 99%

Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review

Zhang

Xiong

et al. 2023

Front. Psychiatry

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“…Twenty-six subjects participated in the MEG session (age range 19–37 years, M =24.33, SD =4.57; 4 female; all right-handed). Previous papers reporting PPI have ranged from 6 to 12 subjects and typically do not report effect size (Bangel et al, 2023; Desideri et al, 2019; Kawasaki et al, 2014; Yamanaka & Yamamoto, 2010); we based our sample size on an estimated effect size of 0.5 and power of 0.8. Both behavioral and MEG sessions were characterized by the same experimental design and procedures (see below).…”

Section: Methodsmentioning

confidence: 99%

Alpha phase-coding supports feature binding during working memory maintenance

Pagnotta,

Santo-Angles,

Temudo

et al. 2024

Preprint

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Working memory (WM) is the ability to retain and manipulate information in mind, which allows mnemonic representations to flexibly guide behavior. Successful WM requires that objects’ individual features are bound into cohesive representations, however the mechanisms supporting feature binding remain unclear. Binding errors (or swaps) provide a window into the intrinsic limits in capacity of WM. We tested the hypothesis that binding in WM is accomplished via neural phase synchrony and swaps result from its perturbations. Using magnetoencephalography data collected from human subjects, in a task designed to induce swaps, we showed that swaps are characterized by reduced phase-locked oscillatory activity during memory retention. We found that this reduction arises from increased phase-coding variability in the alpha-band, over a distributed network of sensorimotor areas. Our findings support the notion that feature binding in WM is accomplished through phase-coding dynamics that emerge from the competition between different memories.

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Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders

Ruan,

Tong,

Jin

et al. 2024

Fundamental Research

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Acute effects of deep brain stimulation on brain function in obsessive–compulsive disorder

Cited by 3 publications

References 37 publications

Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review

Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review

Alpha phase-coding supports feature binding during working memory maintenance

Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders

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