Acute effects of low load resistance training with blood flow restriction on serum growth hormone, insulin-like growth factor-1, and testosterone in patients with mild to moderate unilateral knee osteoarthritis

Chen, Yangguang; Wang, Junguo; Li, Shuoqi; Li, Yinghao

doi:10.1016/j.heliyon.2022.e11051

Cited by 7 publications

(17 citation statements)

References 38 publications

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“…In addition, IGFBP-3 is the major IGF-I carrier protein, and IGF-I concentrations have been shown to increase with higher concentrations of blood GH [ 19 ]. The increase in IGFPB-3 for both protocols between PRE to POST0 and a return to baseline at POST15 are comparable to the results presented by Madarame et al [ 16 ] and Chen et al [ 17 ]. The increases in IGFBP-3 may be attributed to plasma volume reduction [ 35 ] after the exercises in both protocols (LI+ BFR and HI).…”

Section: Discussionsupporting

confidence: 89%

“…Takarada et al [ 19 ] observed greater increases in GH concentration after BFR resistance training compared with a light load exercise protocol without BFR. Kim et al [ 18 ] and Chen et al [ 17 ] reported similar increases in GH between acute BFR resistance exercise and a HI protocol in young and postmenopausal women, respectively. In contrast, Manini et al [ 15 ] demonstrated higher increases in GH after BFR resistance training compared with the HI protocol.…”

Section: Introductionmentioning

confidence: 85%

“…Studies using the BFR method have reported increased levels of specific hormones, especially growth hormones (GH) and insulin-like growth factor-1 (IGF-1) in men [ 5 , 9 , 14 , 15 , 16 ] and women [ 17 , 18 ]. Madarame et al [ 16 ] demonstrated an increase of GH and IGF-1 post lower and upper limb exercises with BFR, with higher values of GH in the lower limb exercises.…”

Section: Introductionmentioning

confidence: 99%

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Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction

Vilaça-Alves

Magalhães

Rosa

et al. 2022

JFMK

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The purpose of this study was to investigate the acute effects of multi-joint resistance exercises (MJRE) with blood flow restriction on hormonal responses. Ten men participated in the study and underwent two experimental protocols in random order: four sets (30, 15, 15, and 15 reps, respectively) of MJRE (half squat and horizontal chest press) were performed with 20% of 1RM and a rest time between sets of 30 s, combined with intermittent blood flow restriction (LI + BFR protocol); and four sets (8, 8, 8, 20 reps, respectively) of the same MJRE performed with 75% of 1RM load (HI protocol), with a 90 s rest between the first three sets and 30 s between the third to the fourth set. Blood samples were collected before (PRE), immediately after (POST), and 15 min after the performance of MJRE (POST15). A time effect was observed for growth hormone (GH) and insulin-like-growth-factor-1-binding-protein-3 (IGFPB-3), but no protocol effects or interactions between protocol and times were observed (p > 0.05). There was no effect of either protocol or time (p > 0.05) on total testosterone, free testosterone, or cortisol concentrations. However, significant (p < 0.05) increases were observed in the GH serum concentrations of 2072.73% and 2278.5%, HI, and LI + BFR protocols, respectively, from the PRE to POST15 test. In addition, there was an increase of 15.30% and 13.29% in the IGFPB-3 concentrations (p < 0.05) from PRE to POST0 times for HI and LI + BFR protocols, respectively. Furthermore, there was a decrease of −6.17% and −11.54%, p = 0.00, between the times POST0 to POST15 in the IGFPB-3 for the HI and LI + BFR protocols, respectively. It is concluded that multi-joint resistance exercises combined with intermittent blood flow restriction seemed to promote acute hormonal responses in a manner similar to traditional exercise with high loads. Future studies may investigate whether chronic use of LI + BFR with MJRE may promote muscle hypertrophy.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction

Vilaça-Alves

Magalhães

Rosa

et al. 2022

JFMK

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“…This review investigated this variable in two studies [19,20]. According to one of the studies, the control group exhibited signi cantly lower levels of IGF-1 than the BFRT and RES groups, both postexercise and 15 min after exercise [19], whereas the other study showed no signi cant improvement in IGF-1 between the BFRT group and the control group [20], which is similar to a previous study [35]. Due to the limited number of studies, we were unable to investigate the impact of BFRT on IGF-1.…”

Section: Discussionmentioning

confidence: 99%

Effects of blood flow restriction training in patients with knee osteoarthritis: A meta- analysis

Li,

Wen,

Zhang

et al. 2023

Preprint

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Background. Knee osteoarthritis (KOA) is a common degenerative disease.Resistance training is considered as an effective approach to reduce the risk of muscle weakness in patients with KOA. Blood flow restriction training (BFRT) with low-load resistance training has better clinical outcomes than low-load resistance training alone. However, the degree of BFRT which works more effectively withlow-load resistance training has not been determined. The purpose of this study is to provide a comprehensive overview of the existing data regarding the impact of blood flow restriction training (BFRT) on quadriceps strength, muscle size, pain, physical function, biomarkers, quality of life, and adverse events in patients with KOA. Method. A comprehensive search was conducted in five English-language electronic databases to identify randomized controlled trials (RCTs) comparing BFRT with conventional resistance training in patients with KOA. The selection of studies was based on predetermined inclusion and exclusion criteria. The methodological quality and evidence quality of the selected studies were evaluated. The retrieval period for the literature was from the creation of the database to June 2023. Results. A total of six RCTs were included in this meta-analysis, examining the effects of BFRT compared with those of conventional resistance training on KOA. The pooled results indicated a significant difference between the BFRT group and the control group in terms of quadriceps strength (SMD 0.39 (95% CI 0.18, 0.60), p = 0.01) and biomarkers (SMD 1.31 (95% CI 0.73, p = 0.00). However, BFRT did not show a significant difference compared to conventional resistance training in muscle size (ES = −0.47 (95% CI −1.51, 0.58), p = 0.45), pain (SMD −0.02, (95% CI −0.29, 0.25), p = 0.88), physical function (ES −0.09 (95% CI −0.37, 0.20), p = 0.14), quality of life (SMD 0.30 (95% CI −0.13, 0.73), p = 0.30) or adverse events (RR 0.45 (95% CI 0.20, 1.01), p = 0.05). Conclusions. The evidence reviewed suggests that BFRT may be beneficial for improving muscle strength and biomarkers compared to control training, but it may not be more effective in treating other symptoms of patients with osteoarthritis of the knee, including those related to muscle size, pain, physical function, quality of life, and adverse events. More high-quality evidence is needed to further investigate its therapeutic effects.

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“…Generally, BFR limits the blood flow during exercise, elevates the mechanical pressure of working muscles, and causes local hypoxia/ischemia ( 23 , 24 ). BFR exercise also generates higher lactic acid accumulation than non-BFR exercises ( 25 ). Despite that several research have demonstrated the reduction of fat mass over long-term BFR exercise ( 26 , 27 ), the exact mechanism remains unclear, and the influence of BFR on regulating appetite is still ambiguous.…”

Section: Introductionmentioning

confidence: 99%

The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study

Li,

Guo,

Wang

et al. 2023

Front. Endocrinol.

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BackgroundN-lactoylphenylalanine (Lac-Phe) is a new form of “exerkines” closely related to lactate (La), which may be able to inhibit appetite. Blood flow restriction (BFR) can lead to local tissue hypoxia and increase lactate accumulation. Therefore, this study investigated the effects of combining Moderate-intensity Continuous Exercise (MICE) with BFR on Lac-Phe and appetite regulation in obese adults.MethodsThis study employed the cross-design study and recruited 14 obese adults aged 18-24 years. The participants were randomly divided into three groups and performed several tests with specific experimental conditions: (1) M group (MICE without BFR, 60%VO2max, 200 kJ); (2) B group (MICE with BFR, 60%VO2max, 200 kJ); and (3) C group (control session without exercise). Participants were given a standardized meal 60 min before exercise and a ad libitum 60 min after exercise. In addition, blood and Visual Analogue Scale (VAS) were collected before, immediately after, and 1 hour after performing the exercise.ResultsNo significant difference in each index was detected before exercise. After exercise, the primary differential metabolites detected in the M and B groups were xanthine, La, succinate, Lac-Phe, citrate, urocanic acid, and myristic acid. Apart from that, the major enrichment pathways include the citrate cycle, alanine, aspartate, and glutamate metabolism. The enhanced Lac-Phe and La level in the B group was higher than M and C groups. Hunger of the B group immediately after exercise substantially differed from M group. The total ghrelin, glucagon-like peptide-1 and hunger in the B group 1 hour after exercise differed substantially from M group. The results of calorie intake showed no significant difference among the indexes in each group.ConclusionsIn conclusion, this cross-design study demonstrated that the combined MICE and BFR exercise reduced the appetite of obese adults by promoting the secretion of Lac-Phe and ghrelin. However, the exercise did not considerably affect the subsequent ad libitum intake.

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Acute effects of low load resistance training with blood flow restriction on serum growth hormone, insulin-like growth factor-1, and testosterone in patients with mild to moderate unilateral knee osteoarthritis

Cited by 7 publications

References 38 publications

Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction

Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction

Effects of blood flow restriction training in patients with knee osteoarthritis: A meta- analysis

The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study

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