Acute Encephalopathy After Initiation of Cranial Irradiation for Meningeal Leukæmia

Oliff, Allen; Bleyer, W. Archie; Poplack, DavidG.

doi:10.1016/s0140-6736(78)91323-5

Cited by 35 publications

(4 citation statements)

References 9 publications

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“…1973). Unrelated to this, acute seizures may occur after starting irradiation therapy (Olift et al 1978), intrathecal methotrexate (Campbell et al 1977) or cytosin arabinoside (Eden et al 1978) treatment. A grand mal seizure, together with somnolence and slowing of EEG pattern was also noted after L-asparaginase application (Campbell et al 1977).…”

Section: Methodsmentioning

confidence: 99%

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹

Hanefeld

Riehm

1980

Neuropediatrics

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A number of neurological disturbances occur during the treatment of childhood malignancies with cytotoxic drugs like vincristine, methotrexate, cytosine-arabinoside, cyclophosphamide, asparaginase and others. Neurological complications range from peripheral neuropathy, myopathy, myelopathy to encephalopathy with methotrexate induced encephalopathy leading to permanent brain damage or death in most cases. Irradiation of the brain can produce transient or permanent brain damage by a direct effect on nervous tissue and by altering the blood brain barrier or the blood circulation. The many conflicting reports concerning the quality of life of long-term survivors of childhood leukaemia do not give sufficient data for final conclusions. The experiences we have encountered over the past ten years seem to confirm the optimistic echo from others. There is, however, an urgent need for a prospective study to answer the all important question: will a child suffering from leukemia emerge physically and mentally unharmed after long and aggressive treatment?

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Section: Methodsmentioning

confidence: 99%

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹

Hanefeld

Riehm

1980

Neuropediatrics

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“…The interaction may result in an acute, subacute, delayed, or chronic consequence. Within 24 hours, the combination of the first fraction of RT and a single dose of IT chemotherapy may cause acute neurologic deterioration, especially in patients with a large burden of neoplastic cells within the CNS that are sensitive to therapy [24]. Such a reaction may be the CNS equivalent of the tumor-lysis syndrome.…”

Section: Temporal Relationships Of Therapy and Toxicitiesmentioning

confidence: 99%

Chemoradiotherapy interactions in the central nervous system

Bleyer¹

1998

Med. Pediatr. Oncol.

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“…Intrathecal chemotherapy combined with cranial irradiation (usually 2 400 rads) has been the most commonly used method. However, several reports have shown the neurotoxicity of this combination (6, 7,9,10,15,[18][19][20][21]. Even in asymptomatic children with ALL 50-60% have shown abnormal computed tomographic (CT) findings (2,17).…”

mentioning

confidence: 99%

Computed Tomographic Findings of the Brain in Children With Acute Lymphocytic Leukemia After Central Nervous System Prophylaxis Without Cranial Irradiation

Kolmannskog

Anke

2008

Acta Paediatrica

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Abstract. Nineteen children in primary remission of acute lymphocytic leukemia (ALL) were investigated by computed tomographic (CT) scans of the brain 2 to 64 (mean 19) months after the central nervous system (CNS) prophylaxis was finished. The CNS prophylaxis consisted of high dose Methotrexate (HDM) intravenously combined with 6–8 doses of Methotrexate intrathecally. Two children received only Methotrexate intrathecally as CNS prophylaxis. In addition three children with ALL who had CNS leukemia were investigated by CT scans of the brain. Only one abnormal CT scan was found among the nineteen asymptomatic children, and one of the three patients with CNS relapse had slightly dilatated subarachnoidal spaces. These results compared with other reports in literature in which the CNS prophylaxis has consisted of intrathecal Methotrexate and cranial irradiation, suggest that there are fewer abnormal CT findings of the brain in patients not receiving cranial irradiation as part of CNS prophylaxis.

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Acute Encephalopathy After Initiation of Cranial Irradiation for Meningeal Leukæmia

Cited by 35 publications

References 9 publications

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹

Chemoradiotherapy interactions in the central nervous system

Computed Tomographic Findings of the Brain in Children With Acute Lymphocytic Leukemia After Central Nervous System Prophylaxis Without Cranial Irradiation

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Acute Encephalopathy After Initiation of Cranial Irradiation for Meningeal Leukæmia

Cited by 35 publications

References 9 publications

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM1

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM1

Chemoradiotherapy interactions in the central nervous system

Computed Tomographic Findings of the Brain in Children With Acute Lymphocytic Leukemia After Central Nervous System Prophylaxis Without Cranial Irradiation

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Product

Resources

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THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹

THERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDHOOD: EFFECTS ON THE NERVOUS SYSTEM¹