Acute Epstein–Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations

Fujiwara, Motohatsu; Miyamoto, Shin’ichi; Iguchi, Kouta; Matsunaka, Toshihiro; Sakashita, Hiromi; Tsuruyama, Tatsuaki; Kanegane, Hirokazu; Marusawa, Hiroyuki; Nakase, Hiroshi; Chiba, Tsutomu

doi:10.1007/s12328-009-0114-8

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Our patient presented with severe gastroenteritis and signs of severe dehydration due to an acute EBV infection with no other physical signs of EBV or HLH. A similar case was observed by Fujiwara et al, where a patient presented with EBV-induced hemorrhagic gastroenteritis with no pharyngitis, lymphadenopathy, splenomegaly, or hepatic dysfunction [7].…”

Section: Discussionsupporting

confidence: 77%

Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant

Nassar¹,

AlBattah

Bukhari³

et al. 2020

Cureus

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Hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal entity with an incidence rate of 1.2 cases per million people per year. HLH is explained as a highly destructive inflammatory consequence of rampant hypercytokinemia due to excessive lymphocyte-mediated activation of macrophages and histiocytes. Primary HLH is a product of genetic dysfunction and could be familial (five subtypes), syndromic immunodeficiency, or as a consequence of mutations predisposing a person to Epstein Barr Virus (EBV) infection. With secondary HLH, there is an identifiable cause provoking the inflammatory reaction, whether it is an infection, an autoimmune disease, or malignancy (particularly hematological). As a result of widespread cytokine deposition, systemic manifestations are seen with a variety of manifestations that can vary between cases. This is a case of a patient who initially presented to the emergency department with fever, altered mentation, and gastroenteritis. Initial investigations showed non-anion gap metabolic acidosis, high white cell count, and deteriorating renal function. Further laboratory tests, bone marrow biopsies, and neurological imaging were conducted throughout the course of admission as the patient further deteriorated systemically. However, it's important to note the abundant neurological manifestations with a worsening level of consciousness and seizures, some of which were categorized as status epilepticus.

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Section: Discussionsupporting

confidence: 77%

Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant

Nassar¹,

AlBattah

Bukhari³

et al. 2020

Cureus

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“…A previous study found high viral loads in small intestinal tissue of infected cats, and viral excretion in the saliva of FcaGHV1 is suspected as a likely transmission route (BEATTY et al, 2014;TROYER et al, 2014). This is similar to EBV, in which the primary infection is transmitted via saliva and cases of gastroenteritis with EBV have been reported (COHEN, 2000;SICA et al, 2009;FUGIWARA et al, 2009). In contrast, the low occurrence of FcaGHV1 verified in kittens (7.7%; 4/52) and female cats (9%; 8/89), may indicate that vertical transmission has little implication in the spread of the virus, such as was verified in seroprevalence study by STUTZMAN-RODRIGUES, 2016.…”

Section: Resultsmentioning

confidence: 71%

Felis catus gammaherpesvirus 1 (FcaGHV1) and coinfections with feline viral pathogens in domestic cats in Brazil

et al. 2018

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Felis catus gammaherpesvirus 1 (FcaGHV1) may causes an asymptomatic infection that result in an efficient transmission and subsequently dissemination of the virus in feline population. This study used molecular detection by qPCR (quantitative PCR) based on DNA polymerase gene fragment amplification to evaluate the occurrence of FcaGHV1 and its correlation with other feline viral pathogens, such as Carnivore protoparvovirus 1 (CPPV-1), Felid alphaherpesvirus 1 (FeHV-1), and feline retroviruses such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). Of the 182 blood samples evaluated 23.6% (43/182) were positives for FcaGHV1. Approximately 37.9% (33/87) of the samples that tested positive for retrovirus were also were positive for FcaGHV1 infection (P<0.0001). Among FIV-infected samples, 49% (24/49) were positive for FcaGHV1 (P<0.0001). FcaGHV1 infection was not associated with FeLV (P>0.66) or CPPV-1 (P>0.46) coinfection. All samples were negative for FeHV-1. Male felines were significantly associated to FcaGHV1 (P<0.0001) and their risk of infection with FcaGHV1 was about of 7.74 times greater compared to females. Kittens (≤ 1year) were the least affected by FcaGHV1 infection, being verified a rate of 7.7% (4/52). Therefore, male cats over one year old and infected with FIV were considerably more likely to be infected with FcaGHV1. To our knowledge, this is the first study to report the occurrence and molecular detection of FcaGHV1 infection in domestic cats in Brazil and in South America.

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Fine needle cytology features of an atypical presentation of infectious mononucleosis

Gerber-Mora

Lillo

Moreno-Silva

et al. 2020

J Oral Maxillofac Pathol

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Acute Epstein–Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations

Cited by 3 publications

References 19 publications

Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant

Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant

Felis catus gammaherpesvirus 1 (FcaGHV1) and coinfections with feline viral pathogens in domestic cats in Brazil

Fine needle cytology features of an atypical presentation of infectious mononucleosis

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