Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

Pureza, Demilto Yamaguchi da; Jorge, Luciana; Sanches, Íris Callado; Irigoyen, Maria-Cláudia; Souza, Romeu Rodrigues de; Angelis, Kátia De

doi:10.1002/mus.23275

Muscle and Nerve

2012

DOI: 10.1002/mus.23275

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Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

Demilto Yamaguchi da Pureza

Luciana Jorge

Íris Callado Sanches

et al.

Abstract: Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics.

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“…The HR measured when both autonomic blockers were administered was considered the intrinsic HR (iHR). The doses of methylatropine and propranolol were used as described previously (16,21). The vagal tone was measured in a group of rats after the administration of a bolus of a solution with methylatropine (2 mg/kg iv; Sigma-Aldrich).…”

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confidence: 99%

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure

Lataro¹,

Silva²,

Fazan³

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Lataro RM, Silva CA, Fazan R Jr, Rossi MA, Prado CM, Godinho RO, Salgado HC. Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure. Am J Physiol Regul Integr Comp Physiol 305: R908 -R916, 2013. First published August 28, 2013 doi:10.1152/ajpregu.00102.2013.-Heart failure (HF) is characterized by elevated sympathetic activity and reduced parasympathetic control of the heart. Experimental evidence suggests that the increase in parasympathetic function can be a therapeutic alternative to slow HF evolution. The parasympathetic neurotransmission can be improved by acetylcholinesterase inhibition. We investigated the long-term (4 wk) effects of the acetylcholinesterase inhibitor pyridostigmine on sympathovagal balance, cardiac remodeling, and cardiac function in the onset of HF following myocardial infarction. Myocardial infarction was elicited in adult male Wistar rats. After 4 wk of pyridostigmine administration, per os, methylatropine and propranolol were used to evaluate the cardiac sympathovagal balance. The tachycardic response caused by methylatropine was considered to be the vagal tone, whereas the bradycardic response caused by propranolol was considered to be the sympathetic tone. In conscious HF rats, pyridostigmine reduced the basal heart rate, increased vagal, and reduced sympathetic control of heart rate. Pyridostigmine reduced the myocyte diameter and collagen density of the surviving left ventricle. Pyridostigmine also increased vascular endothelial growth factor protein in the left ventricle, suggesting myocardial angiogenesis. Cardiac function was assessed by means of the pressure-volume conductance catheter system. HF rats treated with pyridostigmine exhibited a higher stroke volume, ejection fraction, cardiac output, and contractility of the left ventricle. It was demonstrated that the long-term administration of pyridostigmine started right after coronary artery ligation augmented cardiac vagal and reduced sympathetic tone, attenuating cardiac remodeling and left ventricular dysfunction during the progression of HF in rats.

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mentioning

confidence: 99%

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure

Lataro¹,

Silva²,

Fazan³

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

Abstract: Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics.

Cited by 1 publication

References 17 publications

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure

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