Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder

Esquivel, Gabriel; Díaz-Galvis, J.L.; Schruers, Koen; Berlanga, Carlos; Lara-Muñoz, Carmen; Griez, Eric

doi:10.1016/j.jad.2007.07.022

Cited by 67 publications

(82 citation statements)

References 15 publications

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“…30 It should be noted that AE provokes an increase in atrial natriuretic peptide levels (known to induce anxiolytic effects) and a reduction in panic symptoms. 16,31 Meyer et al 18 also showed that PD patients who performed AE for ten weeks, compared to an non-exercised control group, presented reductions in anxiety scores in the 6 th and 10 th weeks. Lambert et al 32 sought to analyze the effects of free exercises and occupational therapy on anxiety as a measure of treatment for PD in patients with moderate to severe anxiety.…”

Section: ■ Discussionmentioning

confidence: 98%

Aerobic exercise reduces anxiety symptoms and improves fitness in patients with panic disorder

Lamego¹,

Lattari²,

Filho³

et al. 2016

Medical Express

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OBJECTIVE:To investigate the effects of a regularly repeated aerobic exercise series on anxiety and maximum oxygen consumption (VO 2max ) in Panic Disorder patients. METHODS: Ten previously sedentary female subjects diagnosed with Panic Disorder performed 36 sessions of aerobic exercise (at 70 to 75% of VO 2max ), 3 times per week during 12 weeks. A cardiopulmonary evaluation (ergospirometry test) was used to set the intensity of training as well as to establish baseline and post-training VO 2max parameters. The assessment of anxiety symptoms was performed at baseline, at the end of the 6 th and 12 th weeks, using the Trait Anxiety Inventory (STAI-T) and State Anxiety Inventory (STAI-S), and the Subjective Units of Distress Scale (SUDS) questionnaires. One-way ANOVA for repeated measurements (at 3 moments: Baseline, 6th week (mid-training) and 12 th week (post-training) was used to compare the evolution of the questionnaires; the Bonferroni post hoc test was applied to identify differences between moments. A dependent t-test was performed for measures of VO 2max . RESULTS: Compared to baseline, (a) STAI-T showed significant anxiety reductions at mid-and post-training moments; (b) STAI-S and SUDS recorded anxiety reductions only at Post-training; (c) VO 2max showed a significant improvement at Post-training. CONCLUSION: This protocol promoted beneficial effects on cardiorespiratory fitness and anxiety levels of Panic Disorder patients.

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Section: ■ Discussionmentioning

confidence: 98%

Aerobic exercise reduces anxiety symptoms and improves fitness in patients with panic disorder

Lamego¹,

Lattari²,

Filho³

et al. 2016

Medical Express

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“…The second experiment reported by Esquivel et al 90 was published in 2007. There, 18 PD patients were similarly divided into two groups, one performing heavy exercise and the other light exercise, both on a bicycle ergometer.…”

Section: Physical Exercisementioning

confidence: 92%

“…89,90 In the first, from 2002, 90 20 healthy volunteers were divided into two equal groups (n=10). Before a 35% CO 2 test, one of those groups performed exercise in a bicycle ergometer for the time required to surpass a blood lactate concentration of 6 mM or until exhaustion.…”

Section: Physical Exercisementioning

confidence: 99%

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

Amaral

Spadaro

Pereira³

et al. 2013

Rev. Bras. Psiquiatr.

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This systematic review assesses the current state of clinical and preclinical research on panic disorder (PD) in which the carbon dioxide (CO 2 ) challenge was used as a trigger for panic attacks (PAs). A total of 95 articles published from 1984 to 2012 were selected for inclusion. Some hypotheses for PD evolved greatly due to the reproducibility of PAs in a controlled environment using the safe and noninvasive CO 2 test. The 35% CO 2 protocol was the method chosen by the majority of studies. Results of the test report specific sensitivity to hypercapnia in PD patients of the respiratory PD subtype. The CO 2 challenge helped assess the antipanic effects of medication and nonpharmaceutical approaches such as physical exercise and cognitive behavioral therapy. The test was also used in studies about the genetic component of PD, in which twins and relatives of PD patients were analyzed.

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“…Em uma revisão recente 5 , pudemos evidenciar que os exercícios físicos podem desempenhar um papel importante no tratamento do TP; isso se manifesta primariamente por meio de seu efeito antipânico agudo 6 e na melhora dos sintomas com a prática regular 7 . Algumas hipóteses mecanísticas foram aventadas para explicar tal efeito, incluindo o aumento dos níveis de fator neurotrófico cerebral (BDNF) 8 e o sistema serotoninérgico 9 . É possível ainda que, dentro da hipótese do condicionamento interoceptivo 10 , a exposição gradual ao exercício físico possa promover habituação do sistema rElato DE CaSo Sardinha A et al do medo às alterações da frequência cardíaca (FC), especialmente naqueles pacientes com maiores escores de ansiedade cardíaca.…”

Section: The Present Article Reports the Use Of An Interval Aerobic Eunclassified

Treinamento físico intervalado como ferramenta na terapia cognitivo-comportamental do transtorno de pânico

Sardinha

Araújo

Nardi

2011

J. bras. psiquiatr.

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rESUMoEste trabalho consiste no relato da utilização de um programa de exercícios físicos aeró-bicos intervalados no contexto da terapia cognitivo-comportamental em um caso de transtorno de pânico e agorafobia. São descritos os procedimentos utilizados, bem como os resultados positivos obtidos na redução da ansiedade cardíaca e na ansiedade cotidiana em relação a situações que exigem esforço físico. A ansiedade cardíaca é um tipo de ansiedade relacionada à saúde em que as preocupações do paciente estão especificamente voltadas para o sistema cardiovascular e para a possibilidade de ter um evento cardiovascular agudo ou de desenvolver uma doença coronariana 3 . Essa envolve ainda dois outros fatores: comportamentos de evitação de atividades ou exercícios físicos e situações desencadeantes de sintomas cardiovasculares percebidos como perigosos e a hipervigilância para a ocorrência de tais sintomas 4 . Em uma revisão recente 5 , pudemos evidenciar que os exercícios físicos podem desempenhar um papel importante no tratamento do TP; isso se manifesta primariamente por meio de seu efeito antipânico agudo 6 e na melhora dos sintomas com a prática regular 7 . Algumas hipóteses mecanísticas foram aventadas para explicar tal efeito, incluindo o aumento dos níveis de fator neurotrófico cerebral (BDNF) 8 e o sistema serotoninérgico 9 . É possível ainda que, dentro da hipótese do condicionamento interoceptivo 10 , a exposição gradual ao exercício físico possa promover habituação do sistema

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Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder

Cited by 67 publications

References 15 publications

Aerobic exercise reduces anxiety symptoms and improves fitness in patients with panic disorder

Aerobic exercise reduces anxiety symptoms and improves fitness in patients with panic disorder

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

Treinamento físico intervalado como ferramenta na terapia cognitivo-comportamental do transtorno de pânico

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