Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Takekura, Hiroaki; Yoshioka, Toshitada

doi:10.2170/jjphysiol.38.689

Cited by 11 publications

(4 citation statements)

References 29 publications

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“…These results suggest the possibility of selective plasticity and modification of muscle fibres depending on exercise characteristics and intensities as reported by Edgerton et al, (1969) and Edgerton (1970). Glycolytic and oxidative enzymes' activities in skeletal muscle following acute endurance exercise have been observed (Takekura & Yoshioka, 1988) and are clearly correlated with enlargement and/or swelling of mitochondria (Bryant et al, 1958). Considering these reports, it is proposed that muscle fibre hypertrophy was influenced by some neurotrophic actions.…”

Section: Discussionsupporting

confidence: 51%

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Different metabolic responses to exercise training programmes in single rat muscle fibres

Takekura

Yoshioka

1990

J Muscle Res Cell Motil

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The aim of this report is to elucidate the effects of exercise training on metabolic properties of different muscle fibre types of the rat hindlimb. Single muscle fibres were dissected from soleus (SOL) or extensor digitorum longus (EDL) muscles of Wistar strain male rats trained on a treadmill for 16 weeks. Each fibre was typed histochemically (SO, slow-twitch oxidative; FOG, fast-twitch oxidative glycolytic; FG, fast-twitch glycolytic). Then glycolytic and oxidative enzymes (CK, LDH, PFK, PK, SDH, and MDH) activities were measured biochemically. Slow-type fibres (SO) were hypertrophied following endurance training and fast-twitch fibres (FOG and FG) were hypertrophied following sprint training. In EDL muscles the distribution of the slow-type fibres was reduced following the sprint training. The activity of glycolytic enzymes increased significantly in the fast-type fibres (FOG and FG) following sprint training, while oxidative enzymes activities increased in both fast (FOG and FG) and slow (SO) muscle fibres following the endurance training. Neither glycolytic nor oxidative enzymes' activities always increased equally in all types of fibre following exercise training. Consequently, the metabolic profiles in each type of single muscle fibre were affected differently by different intensities of exercise training. These results suggest that the functional (enzymes activity) and structural (muscle fibre hypertrophy) changes of skeletal muscle fibre following exercise training appeared gradually, and would be controlled by different factors.

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Section: Discussionsupporting

confidence: 51%

“…The enzyme activity in the muscle fibre tended to rise along with the exercise and to return to the resting level after 48 h of exercise (Takekura & Yoshioka, 1988). Therefore, all rats of the training groups were used for 48 h after the last exercise programme.…”

Section: Methodsmentioning

confidence: 99%

Different metabolic responses to exercise training programmes in single rat muscle fibres

Takekura

Yoshioka

1990

J Muscle Res Cell Motil

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“…The enzyme activity of the skeletal muscle increased following acute exhaustive exercise and normalized after 48 h (TAKEKURA and YosHIOKA, 1988a). Furthermore, GoLLNICK and KING (1969) reported that swelling and/or enlargement of mitochondria in the muscle cells occurred following acute exhaustive exercise.…”

Section: Methodsmentioning

confidence: 98%

Specific mitochondrial responses to running training are induced in each type of rat single muscle fibers.

Takekura

Yoshioka

1989

Jpn.J.Physiol

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The effects of training by running (sprint or endurance) on the mitochondrial volume, number, and succinate dehydrogenase (SDH) activity of different types of single muscle fibers, and on the elemental composition of soleus and extensor digitorum longus muscles were studied employing histochemical, electron microscopic, and electron probe-micro analysis (EPMA). Newly weaned male Wistar rats were trained on a motor-driven treadmill endurance exercise for 14 weeks. The relative mitochondrial volume per single muscle fiber of slow-twitch oxidative (SO) fiber was significantly increased following endurance training (p <0.01). There was no significant correlation between mitochondrial volume and number of SO fibers following endurance exercise training. Following sprint training, both mitochondrial volume and number of fasttwitch oxidative glycolytic (FOG) fibers increased significantly (p <0.01), with significant correlation (r = 0.69) between these parameters. SDH activity was higher in the order of SO, FOG, and fast-twitch glycolytic (FG) fibers following endurance training; however, the activity was higher in the order FOG, SO, and FG fibers following sprint training. The potassium concentration in cytoplasm of the soleus muscle showed a tendency to decrease following both types of training. These results suggest that the oxidative capacity of each type of muscle fiber does not always increase equally following training. Changes in mitochondrial number and volume in response to the two different types of training differed according to the type of fiber.

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“…ATP provides the required energy for contraction–relaxation cycle of muscle. A major source of ATP under anaerobic conditions is creatine phosphorylated by creatine phosphokinase (CPK), a muscle‐specific enzyme ( Takekura & Yoshioka 1988). Myokinase is another muscle‐specific enzyme which catalyses the formation of one ATP molecule from two ADP molecules.…”

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confidence: 99%

Impact of testosterone and oestradiol on region specificity of skeletal muscle‐ATP, creatine phosphokinase and myokinase in male and female Wistar rats

Recchia

Byrne

Kass

1999

Acta Physiologica Scandinavica

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Arterial pulse pressure (PP) increases with exertional stress and ageing, and can modify vessel diameter in smaller vessels. To test if PP must exceed a certain range to influence vessel diameter, and determine if such effects are endothelium-dependent or intrinsic to vascular viscoelasticity, eight fresh excised porcine carotid artery segments were perfused with modified Krebs-Henseleit by a servo-controlled system generating physiological arterial pressure waveforms. In a separate group of vessels (n = 10), the endothelium was mechanically removed. Vessel external diameter was measured by video edge-detection. Vessels partially preconstricted with noradrenaline were perfused at 9 mL min(-1) mean flow, at mean pressure of 90 or 120 mmHg, and zero PP. PP alone was then increased to 40, 70, or 120 mmHg at 1 Hz cycling rate for 5 min, then returned to zero and vessel diameter measured immediately thereafter. The protocol was repeated after 10-20 min stabilization. Mean vessel diameter rose proportionally with PP only once PP exceeded 40 mmHg, with maximal increases of 6-9% at a PP of 120 mmHg. Similar responses were obtained in vessels with and without a functional endothelium, at both mean pressures. Thus, when exposed to higher than normal resting PP, conduit arteries dilate owing to the stress-relaxation response of their viscoelastic wall. This mechanism of PP-mediated vascular dilatation may contribute to enhanced organ perfusion when small resistance arteries are already dilated.

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Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Cited by 11 publications

References 29 publications

Different metabolic responses to exercise training programmes in single rat muscle fibres

Different metabolic responses to exercise training programmes in single rat muscle fibres

Specific mitochondrial responses to running training are induced in each type of rat single muscle fibers.

Impact of testosterone and oestradiol on region specificity of skeletal muscle‐ATP, creatine phosphokinase and myokinase in male and female Wistar rats

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