Acute exposure to water-soluble fractions of marine diesel oil: Evaluation of apoptosis and oxidative stress in an ascidian

Barbosa, Danilo Barreto; Mello, Andressa de Abreu; Allodi, Silvana; Barros, Cíntia Monteiro de

doi:10.1016/j.chemosphere.2018.07.138

Cited by 14 publications

(10 citation statements)

References 46 publications

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“…Differently, a significant reduction in T-AOC was observed following CEWAF exposure compared with the Control, indicating that CEWAF exposure could produce severe damage to the antioxidant defense system in the respiratory tree of sea cucumber. Previous studies have reported that exposure to oil-derived hydrocarbons at relative high concentrations could compromise the ability of antioxidant defense system in marine benthos, which exhibited a significant reduction in the antioxidant enzymatic activities, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) [19,23,48], or in the T-AOC used in the present study, which is an integrated parameter to evaluate the cumulative action of all the antioxidants present in vivo [49]. The damage of the antioxidant defense system could lead to insufficient capacity for scavenging ROS and then a significant net increase in ROS levels, which subsequently could result in extensive oxidative damage of the macromolecules (DNA, proteins, and lipids) [50,51].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, compared with WAF, the proportion of HMW PAHs is much higher in CEWAF, especially in 3-ringed PAHs, which has been reported to be the predominant toxic components of oil-derived hydrocarbons to marine organisms [53,54]. It has also been documented that PAHs could elevate the ROS generation during their metabolism and biotransformation processes in marine benthos, leading to an imbalance between the ROS generation and scavenging [18,19,55,56]. Likewise, the ΣPAHs concentrations in WAF and CEWAF coincided with the oxidative damage observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Response and Oxidative Stress in the Respiratory Tree of Sea Cucumber (Apostichopus japonicus) Following Exposure to Crude Oil and Chemical Dispersant

Liao

et al. 2020

JMSE

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Sea cucumber (Apostichopus japonicus) is mainly cultured in the coastal zone, where it is easily threatened by accidental oil spills. Chemical dispersant is one of the efficient oil spill responses for mitigating the overall environmental damage of oil spills. However, the impact of crude oil and chemical dispersants on sea cucumber is less well known. Hence, the present study focused on exploring the antioxidant response and oxidative stress in the respiratory tree of sea cucumber following exposure to GM-2 chemical dispersant (DISP), water-accommodated fractions (WAF), and chemically enhanced WAF (CEWAF) of Oman crude oil for 24 h. Results manifested that WAF exposure caused a significant increase in the reactive oxygen species (ROS) level (5.29 ± 0.30 AU·mgprot−1), and the effect was much more obvious in CEWAF treatment (5.73 ± 0.16 AU·mgprot−1). Total antioxidant capacity (T-AOC), as an important biomarker of the antioxidant defense capacity, showed an increasing trend following WAF exposure (0.95 ± 0.12 U·mgprot−1) while a significant reduction in T-AOC was observed following CEWAF exposure (0.23 ± 0.13 U·mgprot−1). Moreover, we also evaluated the oxidative damage of the macromolecules (DNA, protein, and lipid), and our results revealed that the presence of chemical dispersant enhanced oxidative damage caused by crude oil to sea cucumber.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidant Response and Oxidative Stress in the Respiratory Tree of Sea Cucumber (Apostichopus japonicus) Following Exposure to Crude Oil and Chemical Dispersant

Liao

et al. 2020

JMSE

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“…Our results show that NO levels were decreased at all time intervals upon exposure to 10, 50, and 100 ng/mL DA. Similarly, Barbosa et al [27] reported that NO 2 − levels were reduced after the ascidian Styela plicata was exposed to the marine water-soluble fraction of diesel oil (WFDO), indicating a reduction in NO production. Manju et al [28] demonstrated the protective properties by using a mouse model of DA-induced temporal lobe epilepsy.…”

Section: Discussionmentioning

confidence: 92%

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Chi

Zhang

Liu

et al. 2019

JMSE

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Domoic acid (DA) is an amnesic shellfish poisoning toxin produced by some species of the genera Pseudo-nitzschia and Nitzschia. This toxin has harmful effects on various species, especially scallops. This study aimed to investigate the effects of DA exposure on the immune and physical responses of bay scallop, Argopecten irradians. Various immunological and physical parameters were assessed (acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxide (LPO), nitric oxide (NO), and the total protein content) in the haemolymph of scallops at 3, 6, 12, 24, and 48 h post-exposure to DA at different concentrations (10, 50, and 100 ng/mL). Moreover, the expression of immune-related genes (CLT-6, FREP, HSP90, MT, PGRP, and PrxV) was assessed. The activities of ACP, ALP, and LDH and the total protein content and LPO increased upon exposure to DA at different concentrations, while NO levels were decreased. Furthermore, immune-related genes were assessed upon DA exposure. Our results showed that exposure to DA negatively impacts immune function and disrupts physiological activities in bay scallops.

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“…Although crude oil comprises thousands of organic compounds, polycyclic aromatic hydrocarbons (PAHs) are generally known as the predominant toxic components of crude oil to marine organisms [27,28]. Several recent studies have reported that oil-derived PAHs could stimulate reactive oxygen species (ROS) production during their biotransformation, resulting in an elevation of ROS levels in marine organisms [2,29,30]. Overelevation of ROS levels could further induce oxidative damage of the biomacromolecules (including DNA, proteins, and lipids) [31,32], which is known as the primary mechanism involved in cell damage, apoptosis, and tissue injury in marine organisms exposed to oil-derived PAHs [29,[33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

“…Several recent studies have reported that oil-derived PAHs could stimulate reactive oxygen species (ROS) production during their biotransformation, resulting in an elevation of ROS levels in marine organisms [2,29,30]. Overelevation of ROS levels could further induce oxidative damage of the biomacromolecules (including DNA, proteins, and lipids) [31,32], which is known as the primary mechanism involved in cell damage, apoptosis, and tissue injury in marine organisms exposed to oil-derived PAHs [29,[33][34][35][36]. Additionally, numerous studies have documented that elevated temperature could cause physiological (e.g., increased oxygen consumption) and histological (e.g., tissue injury) changes in marine organisms, and it has been suggested that elevated temperature could also disturb the balance between endogenous and exogenous ROS levels and thereby cause an incapacity of the antioxidant defense system [23,[37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Elevated Temperature and Crude Oil Pollution on Oxidative Stress and Apoptosis in Sea Cucumber (Apostichopus japonicus, Selenka)

Wang

et al. 2021

IJERPH

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Currently, global climate change and oil pollution are two main environmental concerns for sea cucumber (Apostichopus japonicus) aquaculture. However, no study has been conducted on the combined effects of elevated temperature and oil pollution on sea cucumber. Therefore, in the present study, we treated sea cucumber with elevated temperature (26 °C) alone, water-accommodated fractions (WAF) of Oman crude oil at an optimal temperature of 16 °C, and Oman crude oil WAF at an elevated temperature of 26 °C for 24 h. Results showed that reactive oxygen species (ROS) level and total antioxidant capacity in WAF at 26 °C treatment were higher than that in WAF at 16 °C treatment, as evidenced by 6.03- and 1.31-fold-higher values, respectively. Oxidative damage assessments manifested that WAF at 26 °C treatment caused much severer oxidative damage of the biomacromolecules (including DNA, proteins, and lipids) than 26 °C or WAF at 16 °C treatments did. Moreover, compared to 26 °C or WAF at 16 °C treatments, WAF at 26 °C treatment induced a significant increase in cellular apoptosis by detecting the caspase-3 activity. Our results revealed that co-exposure to elevated temperature and crude oil could simulate higher ROS levels and subsequently cause much severer oxidative damage and cellular apoptosis than crude oil alone on sea cucumber.

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Acute exposure to water-soluble fractions of marine diesel oil: Evaluation of apoptosis and oxidative stress in an ascidian

Cited by 14 publications

References 46 publications

Antioxidant Response and Oxidative Stress in the Respiratory Tree of Sea Cucumber (Apostichopus japonicus) Following Exposure to Crude Oil and Chemical Dispersant

Antioxidant Response and Oxidative Stress in the Respiratory Tree of Sea Cucumber (Apostichopus japonicus) Following Exposure to Crude Oil and Chemical Dispersant

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Combined Effects of Elevated Temperature and Crude Oil Pollution on Oxidative Stress and Apoptosis in Sea Cucumber (Apostichopus japonicus, Selenka)

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