Acute facial paralysis: a virological study

Mulkens, P. S. J. Z.; Bleeker, J. D.; Schröder, F. P.

doi:10.1111/j.1365-2273.1980.tb02150.x

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…The etiology of BP is still uncertain and has been implicated in some theoretical pathways, such as viral infections [14][15][16] , immune-mediated disease [17][18][19] , and microcirculatory failure of the vasa nervosum [20][21][22][23][24] . According to our knowledge, MPV and PDW values in patients with BP have not been assessed previously.…”

Section: Discussionmentioning

confidence: 99%

Increased Mean Platelet Volume in Patients with Bell’s Palsy

Özler¹,

Okuyucu²

2015

Int Adv Otol

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OBJECTIVE:The aim of this study is to investigate the mean platelet volume (MPV) levels in patients with Bell palsy (BP). Moreover, we aimed to find out any correlation between MPV levels and the severity and prognosis of BP. MATERIALS and METHODS:The study group consisted of 30 subjects who presented with BP and 30 control subjects with no evidence of facial nerve pathology. The evaluation of subjects included a detailed history, general physical examination, and assessment of laboratory blood parameters. RESULTS:The mean MPV and platelet distribution width (PDW) values in patients with BP were significantly higher than the control group (p=0.02, p=0.0001 respectively). The mean platelet count (PC) values in the BP group and control group were similar (p=0.169). There was positive correlation between MPV values and grade of facial paralysis (r=0.716, p=0.0001). Also, there was positive correlation between PDW values and grade of facial paralysis (r=0.376, p=0.041). In contrast, there was no correlation between MPV and PDW values and prognosis of facial paralysis (r= 0.275, p=0.142; r= 0.073, p=0.703 respectively). CONCLUSION:There is no previous study that has investigated the association between MPV values and BP in the literature. Higher MPV values in BP patients may be a predictor of worse severity.

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Section: Discussionmentioning

confidence: 99%

Increased Mean Platelet Volume in Patients with Bell’s Palsy

Özler¹,

Okuyucu²

2015

Int Adv Otol

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Bell's palsy and herpes simplex virus

Schirm¹,

Mulkens

1997

APMIS

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Bell's palsy, which is defined as idiopathic peripheral facial paralysis of sudden onset, accounts for >50% of all cases of facial paralysis. Different theories on the etiology of Bell's palsy have been proposed and investigated. Various clinical studies have suggested an etiological link between Bell's palsy and herpes simplex virus (HSV). In addition, animal experiments have shown the ability of HSV to induce facial paralysis. In our opinion, the possible link between Bell's palsy and HSV can only be explored properly by studying the human facial nerve, and especially the geniculate ganglion itself. Different groups have tried to detect hypothetically reactivated and hypothetically latent HSV in the facial nerves of Bell's palsy patients and control patients, respectively. The isolation of infectious HSV from facial nerve tissue by conventional cell culture methods appeared to be very difficult, also when Bell's palsy patients were tested. Instead, modern molecular methods, such as in situ hybridization and the polymerase chain reaction (PCR) could easily detect HSV DNA in geniculate ganglia. The detection of HSV‐specific latency‐associated transcripts in the ganglia of control patients provided further evidence for the hypothetically latent state of HSV in the geniculate ganglia in these patients. Recent PCR experiments performed by a Japanese group strongly suggest that the area adjacent to the geniculate ganglia does not usually contain any HSV at all, except in patients with Bell's palsy. This well‐controlled study provides conclusive evidence that reactivation of HSV genomes from the geniculate ganglia is the most important cause of Bell's palsy. Consequently, it has been suggested that “Bell's palsy” be renamed as “herpetic facial paralysis”.

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Bilateral Facial Paralysis Related to Sexually Transmitted Herpes Simplex: Clinical Course and MRI Findings

Santos

Adour

1993

Otolaryngol.--head neck surg.

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Acute facial paralysis: a virological study

Cited by 3 publications

References 27 publications

Increased Mean Platelet Volume in Patients with Bell’s Palsy

Increased Mean Platelet Volume in Patients with Bell’s Palsy

Bell's palsy and herpes simplex virus

Bilateral Facial Paralysis Related to Sexually Transmitted Herpes Simplex: Clinical Course and MRI Findings

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