Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London.

Darougar, S; Hunter, P A; Viswalingam, M; Gibson, J A; Jones, Barrie R.

doi:10.1136/bjo.62.12.843

Cited by 35 publications

(13 citation statements)

References 10 publications

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“…This finding confirms a previous report that HSV can cause AC. 22 In this study serological evidence of active HSV infection (HSV-IgG antibodies at level of 1/128 or higher in blood or at a level of 1/8 or higher in tears) was found in 16 patients. HSV was not isolated from these patients, and we were unable to find clinical or laboratory evidence of bacterial, CT, or AV infection or allergy.…”

Section: 20mentioning

confidence: 51%

Prevalence of acute conjunctivitis caused by chlamydia, adenovirus, and herpes simplex virus in an ophthalmic casualty department.

Wishart¹,

James²,

Wishart³

et al. 1984

British Journal of Ophthalmology

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SUMMARYThe causes of acute conjunctivitis in 140 consecutive patients attending an ophthalmic casualty department in London were investigated. Laboratory evidence of infection with Chlamydia trachomatis, adenovirus, or herpes simplex virus was found in 52 (37%) cases. In 70 cases (50%) no evidence of infection with these agents was found. In the remaining 18 cases (13%) laboratory results were inconclusive. The importance of these findings, the role of laboratory investigations in the differential diagnosis of acute conjunctivitis, and their cost-benefit are discussed.Acute conjunctivitis (AC) is a common reason for attendance of patients at ophthalmic casualty (outpatient) departments. Most ophthalmologists take little interest in AC because of difficulties in making aetiological diagnoses and the assumption that AC is a self-limiting and benign disease.

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Section: 20mentioning

confidence: 51%

Prevalence of acute conjunctivitis caused by chlamydia, adenovirus, and herpes simplex virus in an ophthalmic casualty department.

Wishart¹,

James²,

Wishart³

et al. 1984

British Journal of Ophthalmology

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“…Hence, these conditions may remain largely unrecognised, and treated unnecessarily with anti-0 1a 2 3 As 2 -wt35 gye.…”

Section: Discussionmentioning

confidence: 99%

“…Primary ocular infection may present as an acute follicular conjunctivitis or keratoconjunctivitis with or without characteristic lid or corneal lesions. 2 In recent years we have observed changes in the epidemiological and clinical features of primary HSV ocular infection in patients attending the External Eye Diseases Clinic at Moorfields Eye Hospital. In this report we present the major features of primary HSV ocular infection observed in 108 patients and compare these with the features of the disease reported previously.…”

mentioning

confidence: 99%

Epidemiological and clinical features of primary herpes simplex virus ocular infection.

Darougar¹,

Wishart²,

Viswalingam³

1985

British Journal of Ophthalmology

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133

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SUMMARY The epidemiological and clinical features of primary herpes simplex virus ocular infection in 108 patients were studied. Of these, 69 (64%) were aged 15 or over and only eight (7%) were under the age of 5. Associated upper respiratory tract infection was found in 38 (35%) patients and systemic disorders such as mild malaise, fever, and aching in 34 (31%) patients. Common symptoms were redness, watering, discharge, itching, irritation, and lid swelling, whereas pain, photophobia, lid vesicles and ulcers, and blurred vision were less frequent. The major signs consisted of vesicles and ulcers on the lids, papillary responses which were more severe in the upper lid conjunctiva, follicles which were more common in the lower lid conjunctiva, fine and coarse epithelial punctate keratitis, and subepithelial punctate keratitis. Dendritic ulcers and disciform keratitis were found in 16 (15%) and two (2%) patients respectively. The clinical forms of primary herpes simplex virus ocular infection varied. Moderate or severe disease was observed in 41 (38%) and 16 (15%) patients respectively. In eight (7%) patients the disease presented as an acute follicular conjunctivitis without characteristic lid or corneal lesions. A chronic blepharoconjunctivitis which lasted for months developed in 16 (15%) patients. The epidemiological and clinical features in our patients were compared with features of the disease reported previously.

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“…Clinical manifestations of primary ocular HSV-1 infections tend to manifest in youths or young adults. Long term studies of ocular HSV-1 in the United States and Britain found the mean age for the first occurrence to be 37.4 years of age and 25 years of age respectively (Darougar et al, 1978; Liesegang, 1988, 1989). The annual incidence of all types of new ocular HSV infections has recently been estimated at 11.8 per 100,000 people in the United States (Young et al, 2010), similar to the incidence of 8.4 per 100,000 people found over two decades ago in a similar population (Liesegang et al, 1989).…”

Section: Herpetic Infectionmentioning

confidence: 99%

Herpes keratitis

Rowe

Leger

Jeon

et al. 2013

Progress in Retinal and Eye Research

260

235

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Herpes Simplex Virus-1 (HSV-1) infects the majority of the world’s population. These infections are often asymptomatic, but ocular HSV-1 infections cause multiple pathologies with perhaps the most destructive being Herpes Stromal Keratitis (HSK). HSK lesions, which are immunoinflammatory in nature, can recur throughout life and often cause progressive corneal scaring resulting in visual impairment. Current treatment involves broad local immunosuppression with topical steroids along with antiviral coverage. Unfortunately, the immunopathologic mechanisms defined in animal models of HSK have not yet translated into improved therapy. Herein, we review the clinical epidemiology and pathology of the disease and summarize the large amount of basic research regarding the immunopathology of HSK. We examine the role of the innate and adaptive immune system in the clearance of virus and the destruction of the normal corneal architecture that is typical of HSK. Our goal is to define current knowledge of the pathogenic mechanisms and recurrent nature of HSK and identify areas that require further study.

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Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London.

Cited by 35 publications

References 10 publications

Prevalence of acute conjunctivitis caused by chlamydia, adenovirus, and herpes simplex virus in an ophthalmic casualty department.

Prevalence of acute conjunctivitis caused by chlamydia, adenovirus, and herpes simplex virus in an ophthalmic casualty department.

Epidemiological and clinical features of primary herpes simplex virus ocular infection.

Herpes keratitis

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