Objective: Study the isolation rate and antibiotic susceptibility of H. influenza detected from nasopharynx of under 5 years old children with Acute Lower Respiratory Tract Infection in Thanh Hoa Pediatric Hospital from 01/01/2018 to 4/30/2018.
Summary: The subjects were 2970 specimens collected from the children under 5 years old who were diagnosed with acute lower respiratory tract infection. Culture, isolation and antibiotic susceptibility testing by disk diffusion (Kirby - Bauer) following the guidelines of the Ministry of Health. Selection of antibiotic disks and interpretations of sensitive, intermediate and resistant results according to the guidelines of the Institute of Clinical and Laboratory Standards (CLSI) 2017.
Result: The isolation rate of H. influenzae was 28.7%, male (28.6%), female children (28.8%), aged 2 - 6 months (27.6%), 7 - 24 months (28.9%) and 25 - 60 months (30.2%). The isolation rate of H. influenzae from bronchitis is 30.9%, followed by bronchiolitis (28.4%) and pneumonia (30.6%). H. influenzae is susceptible to cefotaxime (5.7%), ceftriaxone (11.9%), ceftazidime (1.2%), meropenem (82,6%), imipenem (81,7%), ciprofloxacin (89.4%).
Conclusion: The isolation rate of H. influenzae from nasopharynxis 28.7%. There is no difference in the prevalence of H. influenzae by sex, by age and by disease.H. influenzae is less susceptible to cephalosporin antibiotics, highly susceptible with meropenem, imipenem and ciprofloxacin.