Acute generalized exanthematous pustulosis associated with icodextrin

Meier, Matthew J.; Adams, Brian B.

doi:10.1016/j.jaad.2009.05.026

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…However, all clinical presentations of DIHS include end organ involvement, with possible renal, hepatic, cardiac or neurologic damage, which can be life threatening . AGEP‐DIHS overlap occurs most commonly in association with anti‐epileptics such as carbamazepineand phenytoin and has also been described with allopurinol . DIHS with features of AGEP have also been found in association with ibuprofen and mexiletine .…”

Section: Introductionmentioning

confidence: 98%

“…Specifically, sulfa medications have been reported to produce AGEP in oval erythematous and edematous plaques with pinpoint pustules . In addition, AGEP has been described with other atypical medication triggers including anti‐hypertensives (atenolol, nifedipine and diltiazem), antimycotics (terbinafineand itraconazole) antibiotics (minocycline, sulfapyridine and clindamycin), paracetamol, allopurinol, anti‐inflammatory medications (corticosteroids and oxicam NSAIDs, hydroxychloroquine, dexamethasone), icodextran (a peritoneal dialysate), and intravenous radiocontrast media . We highlight these medications to alert the clinician to the possibility of AGEP with atypical medication triggers.…”

Section: Introductionmentioning

confidence: 99%

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Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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“…A literature search using PubMed and OVID of the terms “AGEP,” “acute generalized exanthemous pustulosis,” and “African American,” “black,” and “African” for AGEP and African Americans returned six cases. Most of the cases involved polypharmacy (4/6) or an immunosuppressed state (4/6) [ 4 , 17 - 20 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis in an African American Male Caused by Trimethoprim-Sulfamethoxazole

Bressler

Minkowitz

Pathak

et al. 2020

Cureus

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Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced autoimmune disease that presents with hundreds of sterile pustules and systemic symptoms. Genetic predisposition, race, and medications prescribed are all factors in AGEP's frequency, which occurs most commonly in Caucasians and with the use of macrolides and aminopenicillins. Cases of AGEP with sulfonamides or in African American patients are rare. To our knowledge, this is the first documented example of trimethoprim-sulfamethoxazole-induced AGEP in an African American male. In this article, we will further discuss our case and review the literature.

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“…Non-drug or non-infectious causes of AGEP include a variety of etiologies. Iatrogenic triggers include icodextrin, iodinated contrast, and iron carboxymaltose infusions [ 28 , 167 – 172 ]. Dietary triggers include curcumin, oral blue dye, and shiitake mushrooms.…”

Section: Pathogenesismentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

et al. 2023

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Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, and drug-induced etiologies. Diagnosis of AGEP depends on both clinical and histologic criteria, as cases of overlap with other disease processes have been reported. Management includes removal of the offending drug or treatment of the underlying cause, if necessary, and supportive care, as AGEP is a self-limited disease. This review aims to provide an overview and update on the epidemiology, pathogenesis, reported precipitating factors, differentials, diagnosis, and management of AGEP.

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Acute generalized exanthematous pustulosis associated with icodextrin

Cited by 9 publications

References 8 publications

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Acute Generalized Exanthematous Pustulosis in an African American Male Caused by Trimethoprim-Sulfamethoxazole

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

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