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Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.

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Opinion statementAs international travel has increased over the years, it is important for the clinician to be aware of communicable diseases in other countries. Infections can be characterized by endemic region, season of travel, method of transmission, and specific disease-defining lesions, which aid the clinician in developing a diagnosis and promptly initiating treatment. We describe common travel-acquired diseases by geographic location, key skin symptoms, and manifestations for early and proper diagnosis, as well as their standard treatment regimen.