Localized myxedema of thyroid disease

Brinster, Nooshin; Garrett, Algin B.; Kostopoulos, Tassia C.

doi:10.1016/j.jaad.2012.11.019

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…She also had an isomorphic response, with further growth of her LM following surgical excisions. This adds to the small body of reports describing worsening of LM in response to surgical or mechanical trauma, some relatively remote [4]. First-line treatment is application of topical corticosteroids and our patient responded well to clobetasol ointment.…”

Section: Case Discussionsupporting

confidence: 49%

Localized myxedema histologically mimicking spindle cell lipoma

Bolton¹,

Bezecny²,

Han³

et al. 2022

DOJ

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Section: Case Discussionsupporting

confidence: 49%

Localized myxedema histologically mimicking spindle cell lipoma

Bolton¹,

Bezecny²,

Han³

et al. 2022

DOJ

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“…Large plaques are often painful and pruritic. When present, hypertrichosis and hyperhidrosis are confined to the pretibial myxedematous skin [63,64].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…In some cases intralesional injection of corticosteroids can be effective. In a patient with lymphedema, medical treatments including IVIg, rituximab, plasmapheresis, and their combination with surgical treatment may have some benefit [63,65].…”

Section: Treatmentmentioning

confidence: 99%

Systemic Sclerosis Mimics

Kodet¹,

Oreská²

2019

New Insights Into Systemic Sclerosis [Working Title]

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Many clinical conditions are presenting with sclerosis of the skin and with tissue fibrosis. These conditions may be confused with systemic sclerosis (SSc, scleroderma). These diseases and disabilities are generally referred to as systemic sclerosis mimics or scleroderma-like syndromes. These disorders have very different etiologies and often an unclear pathogenetic mechanism. Distinct clinical characteristics, skin histology, and disease associations may allow distinguishing these conditions from systemic sclerosis and from each other. A histopathological examination with clinicopathological correlation for diagnosis is important to spare the patients from ineffective treatments and inadequate management. In this chapter, we discussed localized scleroderma, lichen sclerosus, nephrogenic systemic fibrosis, eosinophilic fasciitis, scleromyxedema, and scleredema. These are often detected in the primary care setting and referred to rheumatologists for further evaluation. Rheumatologists, or preferably in collaboration with a dermatologist, must be able to promptly recognize them to provide valuable prognostic information and appropriate treatment options for affected patients.

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“…The systematic effects of elevated T3/T4 manifests as a sped up metabolism and its correlated symptoms. In addition to hyperthyroidism, some patients with GD have clinical involvement of the eyes resulting in Graves' Ophthalmopathy (GO) and the skin resulting in localized myxoedema [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies

et al. 2014

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BackgroundData on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.MethodsWe searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI).ResultsA total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76–0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81–1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60–1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55–0.84, Pz<0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70–0.93, Pz = 0.003, respectively), but not in dominant model (TT+TC vs. CC: OR = 0.92, 95% CI: 0.77–1.11, Pz = 0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models.ConclusionThe IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians.

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Localized myxedema of thyroid disease

Cited by 5 publications

References 4 publications

Localized myxedema histologically mimicking spindle cell lipoma

Localized myxedema histologically mimicking spindle cell lipoma

Systemic Sclerosis Mimics

Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies

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