Acute Glucose Fluctuations and Chronic Sustained Hyperglycemia as Risk Factors for Cardiovascular Diseases in Patients with Type 2 Diabetes

Colette, C; Monnier, L

doi:10.1055/s-2007-985157

Cited by 78 publications

(46 citation statements)

References 18 publications

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“…Moreover, changes in 8-iso-PGF2α excretion were accompanied by similar reduction in TXM excretion, consistent with a cause-and-effect Aging and Disease • Volume 6, Number 2, April 2015 114 relation between enhanced lipid peroxidation and persistent platelet activation. Increase of plasma 8-iso-PGF2α is an early event in the evolution of type 2 diabetes and could precede the development of endothelial dysfunction [118].…”

Section: Oxidative Stress and Dysglicemiamentioning

confidence: 99%

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Bonomini¹,

Rodella²,

Rezzani³

2015

Aging and disease

492

322

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ABSTRACT:The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

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Section: Oxidative Stress and Dysglicemiamentioning

confidence: 99%

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Bonomini¹,

Rodella²,

Rezzani³

2015

Aging and disease

492

322

View full text Add to dashboard Cite

show abstract

“…Chronic hyperglycemia has long been considered to be related to the generation of oxidative stress and is a risk factor for accelerated atherosclerosis. However, acute blood sugar fluctuations in diabetes have recently been documented as a contributing factor in oxidative stress, which may lead to cardiovascular events in patients with DM [20] . In our study, the average FBS levels could reflect chronic hyperglycemia and occurrences of acute hyperglycemia may reflect glucose fluctuations during the treatment period.…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline versus Steroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss with Diabetes

2018

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OBJECTIVES:To compare the efficacy of pentoxifylline with that of conventional steroid therapy in diabetic patients with idiopathic sudden sensorineural hearing loss (ISSNHL) and to compare blood sugar levels during hospitalization. MATERIALS and METHODS:Medical charts were retrospectively reviewed for all diabetic patients admitted to one institution for ISSNHL between 2000 and 2015. We analyzed 298 cases; 50 patients received pulse steroid treatment (steroid group) and 248 received intravenous administration of pentoxifylline only (pentoxifylline group). Hearing change was evaluated by comparing the initial hearing tests with follow-up hearing tests for up to 3 months. Blood sugar levels were also compared between the 2 groups. RESULTS:At 3 months post-treatment, the degree of hearing recovery was similar between the 2 groups. The pure-tone average was improved from baseline by 17.9±21.2 dB in the steroid group and 18.9±20.7 dB in the pentoxifylline group (p=0.776); hearing recovery rates were also similar (40% vs 39.1%; p=0.826). During hospitalization, average fasting blood sugar levels were higher (203.9±92.0 vs 174.4±54.8 mg/dL; p=0.033) and acute hyperglycemia was more common (48.0% vs 33.1%; p=0.044) with steroid versus pentoxifylline treatment. CONCLUSION:Hearing recovery rates did not significantly differ between steroid and pentoxifylline treatment in diabetic patients with ISSNHL, but pentoxifylline appeared to be associated with better blood sugar control.

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“…The effects of blood glucose fluctuation on vascular complications in T2DM have been researched by many scientists. Hanefeld M. et al found that postprandial blood glucose peak can predict myocardial infarction better than fasting glucose [21]; Ceriello et al demonstrated that accelerated oxidative stress accompanying fluctuations in blood glucose levels could worsen endothelial dysfunction more than constant hyperglycemia [22]; Torimoto et al found that fluctuations in blood glucose levels play a significant role in vascular endothelial dysfunction in T2DM [23]; Su et al found that the glucose variability was closely associated with the severity of cardiovascular disease in T2DM; the effect of MAGE on coronary artery was greater than that of HbA1c [9]; Colette and Monnier suggested that the MAGE can serve as the gold standard to measure the blood glucose fluctuation [24]. We found that MAGE in T2DM patients with coronary artery disease was higher than that in T2DM patients without coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Association between Initial Glycemic Variation and 3-Month Cardiovascular Mortality in Diabetic Patients with Acute Ischemic Stroke

Yoon¹,

Shin²,

Kim³

et al. 2015

J Neurocrit Care

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Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, = 40), type 2 DM patients without cardiovascular complications (group B, = 56), and type 2 DM patients with cardiovascular complications (group C, = 92). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00-8:00 and 11:00-13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery.

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Acute Glucose Fluctuations and Chronic Sustained Hyperglycemia as Risk Factors for Cardiovascular Diseases in Patients with Type 2 Diabetes

Cited by 78 publications

References 18 publications

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Pentoxifylline versus Steroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss with Diabetes

Association between Initial Glycemic Variation and 3-Month Cardiovascular Mortality in Diabetic Patients with Acute Ischemic Stroke

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