Acute granulomatous disease of the liver

Gelb, Alvin M.; Brazenas, Nijole V.; Sussman, Howard H.; Wallach, Rony

doi:10.1007/bf02236046

Cited by 16 publications

(1 citation statement)

References 4 publications

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“…Our patients were in many ways similar to those described by Simon and Wolff (17) and by Wolff and Simon (20) and differed from others which had a relatively acute, self-limited febrile course with an excellent prognosis, without treatment (2,4,18). The cases reported in this work presented as fever of unknown origin.…”

Section: Discussionsupporting

confidence: 60%

Idiopathic Granulomatous Hepatitis with a Prolonged Course: Effect of Corticosteroid Therapy

Penchas¹,

Ligumski²,

Eliakim³

1978

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The effect of corticosteroid (or ACTH) therapy on 4 patients with idiopathic granulomatous hepatitis is described. All patients presented with spiking fever and chills and none had jaundice. Only 1 patient had an enlarged tender liver and 3 had splenomegaly. The erythrocyte sedimentation rate was increased in all cases while the white blood cell count was typically normal. Impairment in liver function was insignificant and consisted of a mild elevation of SGOT and alkaline phosphatase activities and prolonged prothrombin time. All patients presented a diagnostic challenge. The diagnosis was established by routine liver biopsies in 3 cases and by laparotomy in the 4th. The etiology could not be established. All patients reacted dramatically to prednisone (or ACTH) after failure of other therapeutic regimens. The disease has, however, been present for 5 years in 1 patient and 10 years in another. Relapses occur after cessation of therapy.

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Section: Discussionsupporting

confidence: 60%