Acute Guttate Psoriasis and Streptococcal Infection

Whyte, Henry J.; Baughman, Richard D.

doi:10.1001/archderm.1964.01590270036008

Cited by 202 publications

(84 citation statements)

References 7 publications

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“…It is generally known that streptococcal throat infections can trigger guttate psoriasis [21,25]. Also, in our study, the patients with high ASO titers more frequently had guttate psoriasis than the patients with normal ASO titers in childhood psoriasis group.…”

Section: Discussionsupporting

confidence: 57%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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Psoriasis is a relatively common disorder in children and can be triggered by an upper respiratory tract infection. The aim of this study was to compare the clinical features of psoriasis in children and adult. In addition, we evaluated the relationship between anti-streptolysin O (ASO) titers and the clinical features of psoriasis. A total of 30 childhood psoriasis patients and 30 adult psoriasis patients were evaluated. Childhood psoriasis had a facial predominance when compared with the adult psoriasis. The childhood psoriasis patients with high ASO titers had guttate psoriasis more frequently than patients with normal ASO titers. In children with plaque-type psoriasis, psoriasis area and severity index score was increased in the high ASO titer group than normal ASO titer group. In conclusion, if the children with psoriasis show increased ASO titer, the physician should pay attention to the worsening of the psoriasis. Furthermore, early treatment of streptococcal infections might be beneWcial in childhood psoriasis.

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Section: Discussionsupporting

confidence: 57%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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“…Although multiple factors may contribute to the exacerbation of psoriasis, there are many reports suggesting that bacterial infection can trigger this illness (6,7,28,29). The relationship between bacterial infection and exacerbation of psoriasis is perhaps most clearly demonstrated in guttate psoriasis where there are multiple reports demonstrating that acute exacerbation of guttate psoriasis, in the majority of patients, is preceded by antecedent infection with group A streptococci and rises in serum antistreptococcal titers (6,7). Patients with this form of psoriasis frequently improve with systemic antibiotic therapy (30).…”

Section: Discussionmentioning

confidence: 99%

“…Guttate psoriasis is a well-defined form of psoriasis which erupts suddenly and is frequently associated with a preceding history of streptococcal throat infection or a rise in serum antistreptococcal titers (6,7). Due to the acute nature of guttate psoriasis and its strong association with streptococcal throat infection, this disease offers a unique opportunity to link the nature of the T cell activation in this subtype of psoriasis with a potential etiologic agent.…”

Section: Introductionmentioning

confidence: 99%

Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis.

Leung¹,

Travers²,

Giorno³

et al. 1995

J. Clin. Invest.

265

191

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Recent studies have suggested that T cells play a critical role in the pathogenesis of psoriasis. Guttate psoriasis is a well-defined form of psoriasis frequently associated with streptococcal throat infection. This study tested the hypothesis that T cells in acute guttate psoriasis skin lesions may be activated by streptococcal superantigens. Peripheral blood as well as lesional and perilesional skin biopsies were analyzed for T cell receptor Vfi repertoire using monoclonal antibodies against 10 different V8 families. Skin biopsies from all patients with acute guttate psoriasis, but not skin biopsies from patients with acute atopic dermatitis or inflammatory skin lesions induced in normal subjects with sodium lauryl sulfate, demonstrated selective accumulation of Vfi2+ T cells (P < 0.05). The expansion of V.82+ T cells occurred in both the CD4+ and the CD8+ T cell subsets.Sequence analysis of T cell receptor chain genes of V/32-expressing T cells from skin biopsies of patients with guttate psoriasis showed extensive junctional region diversity that is more compatible with a superantigen rather than a conventional (nominal) antigen-driven T cell response. All streptococcal isolates from patients with guttate psoriasis secreted streptococcal pyrogenic exotoxin C, a superantigen known to stimulate marked Vj32+ T cell expansion. These data support the concept that acute guttate psoriasis is associated with superantigenic stimulation of T cells triggered by streptococcal superantigen(s). (J. Clin. Invest. 1995. 96:2106-2112

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“…ASO titres were positive in 10% of cases and were found to be positive in patients of guttate psoriasis only. Throat swab culture was found to be positive in 20% of cases and in all the cases, streptococcus haemolyticus was found to be the causative organism [7]. Alcoholism was found to be a triggering factor in 32% of cases.…”

Section: Discussionmentioning

confidence: 92%

Estimation of peroxisome proliferators – activated receptor γ gene expression in inflammatory skin diseases: atopic dermatitis and psoriasis

Mahgoub¹,

Tawdy²,

Metwally³

et al. 2014

Our Dermatol Online

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Introduction: Psoriasis is a genetically determined chronic disease of skin in which a number of biochemical alterations take place during its course. The main objectives of our study were to calculate various biochemical parameters in psoriasis correlate them clinically. Materials and Methods: An attempt was made to detect the biochemical changes during its exacerbations. Fifty biopsy proved psoriasis patients were selected. Clinical examination and the various biochemical tests were performed at the time of enrollment and at the end of eight weeks of treatment. Results: Hyperurecemia was seen in 16% patients and hypocalcemia was seen in 10 % patients and hypoalbuminaemia was seen in 56% patients. Conclusion: With improvement of clinical picture, a shift of biochemical values towards normal was recorded.

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Acute Guttate Psoriasis and Streptococcal Infection

Cited by 202 publications

References 7 publications

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis.

Estimation of peroxisome proliferators – activated receptor γ gene expression in inflammatory skin diseases: atopic dermatitis and psoriasis

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