Acute haemolytic transfusion reaction apparently caused by the ‘enzyme‐only’ anti‐E

Michalewska, Bogumiła; Ejduk, Anna; Pniewska, K.

doi:10.1111/j.1423-0410.2005.00641.x

Cited by 11 publications

(10 citation statements)

References 4 publications

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“…These antigens are the second‐most potent for triggering an immune reaction, after those of the ABO blood group. Anti‐Rh alloantibodies can cause severe or fatal haemolytic transfusion reaction and severe HDFN (Chatziantoniou et al, ; Michalewska et al, ). Overall, the frequencies of all antigens (C, c, E, e) in this study differed from those Thais in Bangkok (Fongsarun et al, ), Mainland Chinese (Yu et al, ), north Indians (Makroo, Gupta, Bhatia, & Rosamma, ) and Taiwanese (Lin et al, ).…”

Section: Discussioncontrasting

confidence: 47%

“…Alloantibodies against Rh (E, c), MNS (Mi a ) and Kidd (Jk a ) blood groups are the most commonly reported in Asian populations (Cheng, Lee, & Lin, ; Romphruk et al, ; Tian et al, ). Moreover, these antibodies have frequently been identified as a cause of haemolytic transfusion reactions and HDFN in a range of studies (Chatziantoniou et al, ; Michalewska, Ejduk, & Pniewska, ).…”

Section: Introductionmentioning

confidence: 99%

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Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Romphruk

Butryojantho

Jirasakonpat

et al. 2019

Int J Immunogenetics

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We here report the first study of antigen and phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd antigens in north‐east Thai blood donors. Blood transfusion services aim to ensure availability of adequate and safe blood to minimize the development of transfusion reactions. For pre‐transfusion testing, the most important blood group systems are ABO and RhD. The transfusion of ABO‐compatible otherwise unknown phenotype blood may result in alloimmunization, especially in multi‐transfused patients. Extended red blood cell (RBC) phenotyping and selection of blood negative for specific antigens reduce post‐transfusion complications and allow for effective blood transfusion regimens to be achieved. A total of 13,567 regular repeated, voluntary Thai blood donors were included for red‐cell antigen typing of Rh (D, C, E, c, e). Samples from 12,768, 9,389 and 13,059 donors were typed for Kidd, M and Mia antigens, respectively. Amongst Rh antigens, e was the most common (96.80%) followed by C (95.50%), c (34.40%) and E (32.20%) with CCDee (60.00%) being the most common phenotype. For Kidd phenotypes, Jk(a+b+) was the most common (46.73%) and Jk(a−b−) was rare (0.07%). For the M and Mia antigen, M(+) was most frequently found (94.96%) and Mia(+) was found in 17.97% of individuals. Knowledge of red‐cell antigen phenotype frequencies in a population is helpful for creating a phenotype database of blood donors which can provide antigen‐negative compatible blood to patients with multiple alloantibodies. Moreover, provision of antigen‐matched blood can prevent alloimmunization in multi‐transfused patients.

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Section: Discussioncontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Romphruk

Butryojantho

Jirasakonpat

et al. 2019

Int J Immunogenetics

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“…A few reports about antibody screening in pregnant women showed different results that enzyme-enhanced methods often detect low concentrations of anti-Rh antibodies not found by other methods (12, 13). In addition, there are some cases of acute hemolytic transfusion reaction (14) or delayed transfusion reactions (11, 15) caused by "enzyme-only" antibodies.…”

Section: Discussionmentioning

confidence: 99%

Screening and Identification of Unexpected Red Cell Antibodies by Simultaneous LISS/Coombs and NaCl/Enzyme Gel Methods

et al. 2009

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We evaluated the clinical usefulness of simultaneous LISS/Coombs and NaCl/Enzyme testing using the gel method for screening and identification of unexpected antibodies in 15,014 samples. When unexpected antibodies were detected by either screening test, those antibodies were identified using both the LISS/Coombs and the NaCl/Enzyme gel test. The positive screening rates of the LISS/Coombs, NaCl/Enzyme, and combined tests (excluding 25 autoantibody cases) were 0.48%, 1.29%, and 1.39%, respectively. Among the 57 samples positive by both screening methods, the antibodies in 19.3% could be identified only by the NaCl/Enzyme method. Among the 137 samples positive only by NaCl/Enzyme screening, 74.5% showed positive results in antibody identification only by the NaCl/Enzyme test, although 7.3% were also positive in the LISS/Coombs test. The NaCl/Enzyme method thus showed about threefold higher detection rates than the LISS/Coombs method, especially in screening for Rh antibodies, and higher exact identification rates and discriminatory power for identifying mixed antibodies. Addition of the NaCl/Enzyme method to routine laboratory procedures may detect and identify considerable numbers of significant antibodies that might be missed if only the LISS/Coombs method is used.

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“…Naturally occurring anti-E has not shown any evidence of haemolytic transfusion reaction 3 or haemolytic disease of foetus and newborn (HDFN) 4 and thus categorised as of non-clinical significance 5 . However, Michalewska et al (2005) 6 has reported a case of 'Enzyme-only' anti-E to be associated with acute haemolytic transfusion reaction, but it was not mentioned whether this anti-E is naturally occurring or not. In standard transfusion practice, any patient with clinically significant alloantibody irrespective whether it is of naturally occurring or following sensitization, antigen negative red cell must be given for transfusion.…”

Section: Case Reportmentioning

confidence: 99%

Naturally Occurring ‘enzyme only’ Anti-E antibody: A Rare Occurrence

Yousuf

Thalith

Loong³

et al. 2019

Bangladesh J Med Sci

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Naturally occurring anti-E, present without obvious antigenic stimulation is a rare occurrence of red cell antibody of the Rh blood group system. It is mentioned that such naturally occurring anti-E react only with enzyme modified E-positive red cells. This case report describes a rare case of naturally occurring anti-E in a patient with autoimmune haemolytic anaemia (AIHA). Bangladesh Journal of Medical Science Vol.18(4) 2019 p.818-819

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Acute haemolytic transfusion reaction apparently caused by the ‘enzyme‐only’ anti‐E

Cited by 11 publications

References 4 publications

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Screening and Identification of Unexpected Red Cell Antibodies by Simultaneous LISS/Coombs and NaCl/Enzyme Gel Methods

Naturally Occurring ‘enzyme only’ Anti-E antibody: A Rare Occurrence

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Acute haemolytic transfusion reaction apparently caused by the ‘enzyme‐only’ anti‐E

Cited by 11 publications

References 4 publications

Phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Screening and Identification of Unexpected Red Cell Antibodies by Simultaneous LISS/Coombs and NaCl/Enzyme Gel Methods

Naturally Occurring ‘enzyme only’ Anti-E antibody: A Rare Occurrence

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Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand