Acute Hepatic Coma Treated by Cross-Circulation With a Baboon and by Repeated Exchange Transfusions

Saunders, S. J.; Terblanche, J.; Bosman, S.C.W.; Harrison, Gillian; Walls, RM; Hickman, Rosemary; Biebuyck, Julien F.; Dent, D. M.; Pearce, Simon H. S.; Barnard, C. N.

doi:10.1016/s0140-6736(68)90692-2

Cited by 42 publications

(3 citation statements)

References 4 publications

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“…On the other hand, during fulminant hepatic failure cerebral death is responsible for 50% of deaths (Ware et al, 1971;Gazzard et al, 1975;, even when liver regeneration occurs (Rueffand Benhamou, 1973;Scotto et al, 1973;Opolon et al, 1975). Hence, the need for artificial support to prevent irreversible brain damage has led recently to numerous experimental and clinical trials: interhuman (Muller et al, 1971;Sicot et al, 1972;Rueff et al, 1974) or heterologous cross-circulation (Saunders et al, 1968;Hume et al, 1969), total body washout (Klebanoff et al, 1972), and charcoal haemoperfusion (Gazzard et al, 1974). Previous laboratory experiments showed that haemodialysis with high permeability polyacrylonitrile membrane (AN 69) allowed progressive consciousness and EEG enhancement in 60% of comatose animals after acute liver ischaemia (Opolon et al, 1976a).…”

mentioning

confidence: 99%

Treatment of encephalopathy during fulminant hepatic failure by haemodialysis with high permeability membrane.

Denis¹,

Opolon²,

Nusinovici³

et al. 1978

Gut

117

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SUMMARY Forty-one patients with fulminant hepatic failure and coma underwent 180 periods of haemodialysis with polyacrylonitrile membrane (AN 69 HD). Hepatic failure was due to viral hepatitis in 40 and drugs in one. Total recovery of consciousness occurred in 17 patients (43*6%), and partial in seven (17-9 %)-that is, an overall figure of 615 %. Regain of consciousness was not related to liver regeneration as assessed by levels of factor V and hepatocyte volume fraction. At the time of the first haemodialysis, neurological status was significantly impaired in the patients who could not be aroused. Mean duration of coma grade IV averaged 6-1 ± 4X3 days and mean duration of illness until death or decerebration 8-6 + 8-3 days. Of the 17 patients who totally regained consciousness, nine recovered and eight died (three from intercurrent complications and five with no liver regeneration).

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mentioning

confidence: 99%

Treatment of encephalopathy during fulminant hepatic failure by haemodialysis with high permeability membrane.

Denis¹,

Opolon²,

Nusinovici³

et al. 1978

Gut

117

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“…Crosscirculation may also be performed between man and baboon. (Saunders et al, 1968;Abouna et al, 1970). Baboons are in short supply in most parts of the world and observations of its value need to be extended and controlled.…”

Section: Direct Exchange Transfusion (Cross-circulation)mentioning

confidence: 99%

The management of acute hepatic failure

Sherlock¹,

Parbhoo²

1971

Postgraduate Medical Journal

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“…While there• is very little information available on the red cell survival rate in nonhuman primates it was generally assumed to be similar to that in man. Considerable interest has arisen over the use of primate animals in immunological stimulation [7], cross-circulation with human beings [9], production of antilymphocytic serum [7], experimental transplantation [1], blood group genetics [6], and testing of drugs [10]. In all these studies the knowledge of normal life-span of erythrocytes in apes and monkeys is essential.…”

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confidence: 99%