Acute Hepatic Encephalopathy in a Female Patient With Hepatitis E Virus With a Favourable Treatment Outcome: A Case Report

Abstract

The article covers the case of HEV with clearly marked clinical manifestations in a 25-year-old non pregnant woman resident in non-endemic region without bad habits and chronic somatic diseases. The case has been confirmed by the detection of IgM and IgG antibodies against HEV. Viral hepatitises А, В, С, D, G have been ruled out by laboratory test results (АТ-IgM HAV, HBsAg, AT-IgM HBcAg, DNA HBV, AT HCV cumulative, RNA HCV, RNA HDV, RNA HGV are not detected), as well as Wilson's disease, toxic and autoimmune hepatitises. On the 35th day, severe progression of the disease was aggravated by hepatic encephalopathy grade IV. This patient's combination therapy is characterized by absence of glucocorticosteroids in the course of treatment and by four plasmapheresis treatment sessions that were effective despite marked coagulopathy.