Acute Hepatitis due to Garcinia Cambogia Extract, an Herbal Weight Loss Supplement

Sharma, Akshay; Akagi, Elisa; Njie, Aji; Goyal, Shubham; Arsene, Camelia; Krishnamoorthy, Geetha; Ehrinpreis, Murray N.

doi:10.1155/2018/9606171

Cited by 19 publications

(15 citation statements)

References 9 publications

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“…141 The levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and bilirubin of a 57-year-old female consuming G. cambogia with no history of liver disorders were 738 U/L (normal range: 7-40 U/L), 856 U/L (normal range: 5-50 U/L), 80 U/L (normal range: 40-150 U/L) and 2.4 mg/dL (normal range: 0.0-1.5 mg/dL) respectively. 142 Following the consumption of G. cambogia, a 36year-old female had fatigue, anorexia and jaundice. The levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and bilirubin were 5615 U/L (normal range: 7-40 U/L), 5340 U/L (normal range: 5-50 U/L), 104 U/L (normal range: 40 -150 U/L), 7.4 mg/dL (normal range: 0.0-1.5 mg/dL) respectively.…”

Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

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The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

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Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

View full text Add to dashboard Cite

show abstract

“…In spite of this, other authors have reported toxic manifestations, including hepatotoxicity, acute pancreatitis, serotonin toxicity and psychosis after the consumption of Garcinia-containing products (either as an extract containing other components or pure). In 16 of the 21 cases described in Table 2 [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ], these adverse effects have occurred after the intake of formulations which contained other ingredients besides Garcinia. One of these formulations is Hydroxycut™.…”

Section: Negative Effects On Healthmentioning

confidence: 99%

Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight

2021

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Nowadays, obesity is one of the great nutritional problems facing public health. The prevalence of this pathology has increased in a worrying way over recent years, currently reaching epidemic proportions. In this context, nutritional supplements are presented as a therapeutic alternative to which more and more people are turning to. Nutritional supplements to lose weight based on the Garcinia plant, specifically on Garcinia cambogia, are commonly used. The active principle of this plant to which these properties have been attributed, is hydroxycitric acid (HCA). The aim of the present review is to gather reported data concerning the effectiveness of nutritional supplements based on Garcinia extracts on weight loss and their possible negative effects. Contradictory results have been observed regarding the effectiveness of the supplements. While statistically significant weight loss was observed in some studies, no changes were found in others. Regarding safety, although Garcinia supplements have been revealed as safe in the vast majority of the studies carried out in animal models and humans, some cases of hepatotoxicity, serotonin toxicity and mania have been reported. In conclusion, the results suggest that Garcinia-based supplements could be effective in short-term weight loss, although the data are not conclusive. In addition, the safety of the complement should be further studied.

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“…Although in short term trials GC has been proven as generally safe, it is noteworthy to underline that FDA urged consumers to avoid Hydroxycut, a natural product for weight loss containing GC and a variety of other ingredients, because of the report of twenty-three cases of hepatotoxicity associated with its use in 2009 [232]. Moreover, several hepatoxicity cases have been associated also with the use of pure GC extracts [233][234][235][236][237][238].…”

Section: Garcinia Cambogiamentioning

confidence: 99%

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

et al. 2020

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The use of food supplements for weight loss purposes has rapidly gained popularity as the prevalence of obesity increases. Navigating through the vast, often low quality, literature available is challenging, as is providing informed advice to those asking for it. Herein, we provide a comprehensive literature revision focusing on most currently marketed dietary supplements claimed to favor weight loss, classifying them by their purported mechanism of action. We conclude by proposing a combination of supplements most supported by current evidence, that leverages all mechanisms of action possibly leading to a synergistic effect and greater weight loss in the foreseen absence of adverse events. Further studies will be needed to confirm the weight loss and metabolic improvement that may be obtained through the use of the proposed combination.

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Acute Hepatitis due to Garcinia Cambogia Extract, an Herbal Weight Loss Supplement

Cited by 19 publications

References 9 publications

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

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