Acute high-altitude illness

Hofmeyr, Ross; Tölken, G; Decker, Rik De

doi:10.7196/samj.2017.v107i7.12612

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…Furthermore, clinical guidelines do not specify how to interpret Hb values from individuals residing in higher altitude settings [20][21][22], which makes up a substantial proportion of South Africa's population [35]. The results of this study indicate that the current point-of-care threshold to detect anaemia (<12 g/dL) has poor sensitivity (35.1%) for the detection of ID (88.6% specificity) in women residing at an altitude of 1700 m above sea level.…”

Section: Discussionmentioning

confidence: 99%

Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa

et al. 2020

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In South Africa, haemoglobin (Hb) is measured to screen for iron deficiency (ID). However, low levels of Hb are only a late stage indicator of ID. Furthermore, Hb values are generally not adjusted for altitude even though recommended by WHO. We determined the Hb threshold with the highest combined sensitivity and specificity for detecting ID among South African women living at 1700 m above sea level. In a cross-sectional study of 492 18–25-year-old women, we measured Hb and iron status biomarkers. Using receiver operating characteristic curves, we determined the Hb threshold with maximum Youden Index for detecting ID. This threshold of <12.35 g/dL resulted in a 37.2% anaemia prevalence (20.9% IDA), and sensitivity and specificity of 55.7% and 73.9%, respectively. The WHO altitude-adjusted threshold of <12.5 g/dL resulted in a 39% anaemia prevalence (21.3% IDA), and sensitivity and specificity of 56.8% and 70.8%, respectively. In contrast, using the unadjusted Hb cut-off of <12 g/dL resulted in a 18.5% anaemia prevalence (12.6% IDA), and sensitivity and specificity of 35.1% and 88.6%, respectively. In this sample of South African women of reproductive age an Hb threshold <12.35 g/dL had the highest combined sensitivity and specificity for detecting ID. The diagnostic performance of this Receiver operating characteristic curve-determined threshold was comparable to the altitude-adjusted threshold proposed by WHO. Thus, clinical and public health practice in South Africa should adopt adjustment of Hb for altitude to avoid underestimation of ID and missing women in need for intervention.

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Section: Discussionmentioning

confidence: 99%

Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa

et al. 2020

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“…In the spirit of growing the discipline in southern Africa, local enthusiasts and experts in the fields present this series of CME articles on wilderness medicine topics, with a focus on their relevance in the region. In this edition, the scope stretches from ocean to mountain, discussing the risks and management of high-altitude illnesses, [1] an update on drowning in SA, [2] and the management of cold-exposure injuries. [3] A further edition in the series will address expedition medicine, psychological and human factors, and heat-related illness.…”

Section: Cmementioning

confidence: 99%

Wilderness medicine in southern Africa

2017

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“…A translated version of the LLS in Hindi could be helpful in the early detection of AMS. Early recognition of AMS is key to allowing individuals to seek medical attention before the risks of complications increases 13 .…”

Section: Introductionmentioning

confidence: 99%

Psychometric Validation of Hindi Version of 2018 Lake Louise Acute Mountain Sickness Scoring System

Dass¹,

Chosphel²,

Kumar³

2019

IJCRR

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Background: The Lake Louise Score (LLS)-2018 is a revised 4-item questionnaire used in the diagnosis of Acute Mountain Sickness. However, a validated Hindi translation of LLS-2018 is not available. Material and Method: Fifty Hindi-speaking volunteers self-reported the translated Hindi version of LLS-2018 after active ascent to high altitude (11,500 ft). It was then tested for its face validity and internal consistency. Result: The Cronbach's alpha was 0.69 and the corrected item score correlation was greater than 0.3. Conclusion: The simple psychometric properties validate the Hindi version of LLS-2018 for the diagnosis of Acute Mountain Sickness.

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Acute high-altitude illness

Cited by 10 publications

References 27 publications

Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa

Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa

Wilderness medicine in southern Africa

Psychometric Validation of Hindi Version of 2018 Lake Louise Acute Mountain Sickness Scoring System

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