Acute hyperkalemia leading to flaccid paralysis: a review of hyperkalemic manifestations

Karmacharya, Paras; Poudel, Dilli Ram; Pathak, Ranjan; Rettew, Andrew; Alweis, Richard

doi:10.3402/jchimp.v5.27993

Cited by 9 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although ZS-9 is certainly one of the potential agents for the treatment of acute hyperkalemia in the future, the HARMONIZE trial ( 1 ) was conducted in an outpatient setting and did not include hospitalized patients. Moreover as mentioned in our article ( 2 ), the mean K+ level in the HARMONIZE trial was 5.6 mEq/L with only nine patients with baseline serum K+ >6.5 mEq/L. While the substudy ( 3 ) quoted by the authors showed a significant decline in the mean serum potassium level (0.4 and 0.6 mmol per liter at 1 and 2 hours, respectively), it had a mean baseline serum K+ of 6.3 mEq/L (95% CI – 6.2–6.4).…”

supporting

confidence: 60%

Response to Letter

Karmacharya

Poudel

Pathak

et al. 2015

Journal of Community Hospital Internal Medicine Perspectives

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 60%

Response to Letter

Karmacharya

Poudel

Pathak

et al. 2015

Journal of Community Hospital Internal Medicine Perspectives

Self Cite

View full text Add to dashboard Cite

“…Our study provides an overview of the heterogenic spectrum of MMs. In the literature only case reports and review articles on differential diagnosis of NTSCI exist ( 7 , 16 , 22 ). In our sample, peripheral nerve disorders were the predominant MM.…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentation and Causes of Non-traumatic Spinal Cord Injury: An Observational Study in Emergency Patients

et al. 2021

View full text Add to dashboard Cite

Introduction: Diagnosing non-traumatic spinal cord injury (NTSCI) is often challenging. However, clear discrimination from non-spinal pathologies, e.g., “myelopathy-mimics” (MMs), is critical in preventing long-term disability and death. In this retrospective study we (1) investigated causes of NTSCI, (2) identified clinical markers associated with NTSCI and (3) discuss implications for NTSCI management.Methods: Our sample consisted of 5.913 consecutive neurological and neurosurgical patients who were treated in our emergency department during a one-year period. Patients with a new or worsened bilateral sensorimotor deficit were defined as possible NTSCI. We then compared clinical and imaging findings and allocated patients into NTSCIs and MMs.Results: Of ninety-three included cases, thirty-six (38.7%) were diagnosed with NTSCI. Fifty-two patients (55.9%) were classified as MMs. In five patients (5.4%) the underlying pathology remained unclear. Predominant causes of NTSCI were spinal metastases (33.3%), inflammatory disorders (22.2%) and degenerative pathologies (19.4%). 58.6% of NTSCI patients required emergency treatment. Presence of a sensory level (p = <0.001) and sphincter dysfunction (p = 0.02) were the only significant discriminators between NTSCI and MMs.Conclusion: In our study, one-third of patients presenting with a new bilateral sensorimotor deficit had NTSCI. Of these, the majority required emergency treatment. Since there is a significant clinical overlap with non-spinal disorders, a standardized diagnostic work-up including routine spinal MRI is recommended for NTSCI management, rather than an approach that is mainly based on clinical findings.

show abstract

“…It is advised to measure plasma potassium if thrombocytosis or severe leukocytosis is present 5,12 . Arrhythmia is a feature of hyperkalemia that could be life-threatening and that could also be caused by other diseases 100 . It is important to differentiate arrhythmia caused potassium imbalance from by other electrolyte imbalance e.g.…”

Section: Differential Diagnosis Of Hyperkalemiamentioning

confidence: 99%

Potassium homeostasis, oxidative stress, and human disease

Udensi

Tchounwou

2017

Int J Clin Exp Physiol

115

View full text Add to dashboard Cite

Potassium is the most abundant cation in the intracellular fluid and it plays a vital role in the maintenance of normal cell functions. Thus, potassium homeostasis across the cell membrane, is very critical because a tilt in this balance can result in different diseases that could be life threatening. Both Oxidative stress (OS) and potassium imbalance can cause life threatening health conditions. OS and abnormalities in potassium channel have been reported in neurodegenerative diseases. This review highlights the major factors involved in potassium homeostasis (dietary, hormonal, genetic, and physiologic influences), and discusses the major diseases and abnormalities associated with potassium imbalance including hypokalemia, hyperkalemia, hypertension, chronic kidney disease, and Gordon’s syndrome, Bartter syndrome, and Gitelman syndrome.

show abstract

Acute hyperkalemia leading to flaccid paralysis: a review of hyperkalemic manifestations

Cited by 9 publications

References 7 publications

Response to Letter

Response to Letter

Clinical Presentation and Causes of Non-traumatic Spinal Cord Injury: An Observational Study in Emergency Patients

Potassium homeostasis, oxidative stress, and human disease

Contact Info

Product

Resources

About