Acute Hypobaric-Hypoxia Challenge and Salivary Cortisol and DHEA-S in Healthy Male Subjects

Pontremolesi, S; Biselli, Roberto; G, Ciniglio Appiani; D’Amelio, Raffaele; Sica, Simona; Fr, Patacchioli

doi:10.3357/asem.3080.2012

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…[55][56][57] In addition, the HPA axis and ANS activities were studied by monitoring changes in the salivary biomarker daily trajectories and by calculating the AUC of their diurnal production, a more reliable approach than isolated single point sampling. 12,31,58 OSA children exhibit higher diurnal salivary cortisol production both in the morning and evening. These findings are consistent with sustained hyperactivation of the HPA axis in OSA children.…”

Section: Discussionmentioning

confidence: 98%

“…Of note, salivary sampling strategies were stringently followed in the present study to prevent any of the typical confounders potentially associated salivary biomarker measurements . In addition, the HPA axis and ANS activities were studied by monitoring changes in the salivary biomarker daily trajectories and by calculating the AUC of their diurnal production, a more reliable approach than isolated single point sampling …”

Section: Discussionmentioning

confidence: 99%

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Salivary biomarkers of obstructive sleep apnea syndrome in children

et al. 2014

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Salivary biomarkers of obstructive sleep apnea syndrome in children

et al. 2014

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“…Our animal model shows endogenous GC (corticosterone) response alleviates DHx effect (Figure 3). Hypoxia also increases GC (cortisol) in humans [49, 50]. If increased cortisol acts similarly, GC administration against hypoxia may be reasonable.…”

Section: Discussionmentioning

confidence: 99%

A mouse model of insomnia with sleep apnea

Masubuchi

Yano

Komatsu

et al. 2022

Preprint

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Obstructive sleep apnea (OSA) patients are exposed to nighttime hypoxia during sleep by intermittent airway closure and feel daytime strong sleepiness. Strangely, insomnia co-occur in some OSA patients, which is called co-morbid insomnia and sleep apnea (COMISA). Here, we show activity responses to daytime hypoxia (DHx) in nocturnal mice were comparable to daytime sleepiness and co-occurring nighttime insomnia in COMISA. DHx reduced activity in active phase (AP) and increased following activity in activity ending phase (AEP). This down-and-up activity response (DUR) by DHx was also observed in molecular clock deficient Cry1 and Cry2 double knockout mice (CryDKO) expressing nighttime activity rise under light-dark cycle (LD) and not observed in arrhythmic CryDKO under constant darkness (DD). When daytime timing hypoxia was exposed at transition from LD to DD, about every 6 h down and up and down wavelike activity responses appeared in arrhythmic CryDKO. Results indicate this wavelike response and AP activity overlap and cause DUR in rhythmic mice. DHx increased plasma corticosterone and this increase antagonized AP activity reduction by DHx. DHx reduced forebrain adenosine and morning adenosine inhibition by caffeine induced DUR. Adenosine inhibition by caffeine or istradefylline at transition from LD to DD induced wavelike response in CryDKO. It is possible that wavelike response is damped oscillation because, interestingly, chronic caffeine treatment induced circasemidian and/or circadian activity rhythms in arrhythmic CryDKO. Evening caffeine attenuated DUR by DHx, which suggested adenosine inhibition chronotherapy may improve OSA/COMISA symptoms. Our animal model will be useful to understand COMISA.

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“…Cortisol is one of the main glucocorticoids, produced in the adrenal gland cortex, and has a wide metabolic effect [ 21 , 22 , 23 ]. Some studies show cortisol rises after hypoxic exposure [ 24 , 25 ], although on the other hand, there are some studies showing no effect after such exposure [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration

Chroboczek

Kujach

Łuszczyk

et al. 2022

IJERPH

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Background: Decreased SpO2 during hypoxia can cause cognitive function impairment, and the effects of acute hypoxia on high-order brain functions such as executive processing remain unclear. This study’s goal was to examine the impact of an acute normobaric hypoxia breathing session on executive function and biological markers. Methods: Thirty-two healthy subjects participated in a blind study performing two sessions of single 30 min breathing bouts under two conditions (normoxia (NOR) and normobaric hypoxia (NH), FIO2 = 0.135). The Stroop test was applied to assess cognitive function. Results: No significant difference was observed in the Stroop interference in the “reading” part of the test in either condition; however, there was a significant increase in the “naming” part under NH conditions (p = 0.003), which corresponded to a significant decrease in SpO2 (p < 0.001). There was a significant increase (p < 0.013) in the brain-derived neurotrophic factor (BDNF) level after NH conditions compared to the baseline, which was not seen in NOR. In addition, a significant drop (p < 0.001) in cortisol levels in the NOR group and a slight elevation in the NH group was noticed. Conclusions: According to these findings, acute hypoxia delayed cognitive processing for motor execution and reduced the neural activity in motor executive and inhibitory processing. We also noted that this negative effect was associated with decreased SpO2 irrespective of a rise in BDNF.

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Acute Hypobaric-Hypoxia Challenge and Salivary Cortisol and DHEA-S in Healthy Male Subjects

Cited by 6 publications

References 12 publications

Salivary biomarkers of obstructive sleep apnea syndrome in children

Salivary biomarkers of obstructive sleep apnea syndrome in children

A mouse model of insomnia with sleep apnea

Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration

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