Acute Hyponatremic Encephalopathy After a Cerebrovascular Accident

Moussa, Nagi A.; Osman, A.R.; Yahya, Taher

doi:10.1016/s0002-9629(15)40372-6

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…20 In another study, urinary sodium and potassium excretion was highest on day 1 of stroke and decreased progressively on day 10. 21 We were able to record levels of sodium and potassium only on day one. Evidence derived from studies indicates the association of a reduction in sodium intake with reduced events of CVA, suggesting a protective role of limiting dietary sodium intake.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of serum electrolytes and lipid levels in ischaemic and haemorrhagic stroke

Wali

Patil

2016

Int J Res Med Sci

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Disorders of serum electrolytes i.e. sodium and potassium are the commonest electrolyte abnormalities found in stroke patients. 5 Electrolyte disturbances such as ABSTRACT Background: Stroke or cerebrovasular accident is a major cause of disability worldwide and the second most common cause of death after ischaemic heart disease. There has been a steady increase in incidence of stroke; recent data shows that stroke incidence decreased by 42% in high-income countries and by 100% in low to middle income countries. Aim of the study was to know the association of serum electrolytes and lipid levels in stroke. Methods: This was a retrospective study conducted in June 2014 at tertiary care hospital in South India. Data was obtained from the medical records departments from June 2011 to August 2012. An adult Treatment Panel III criterion was used to classify plasma lipid levels. The serum urea, serum creatinine, serum electrolytes and urinary electrolyte levels were measured by flame photometry. Descriptive statistics has been carried out in the present study. Student 't' test used to test the significance, between the groups and P value of <0.05 were considered as moderately significant, P values of <0.01 was considered highly significant. Results: There was no statistically significant difference in electrolyte levels between ischaemic and haemorrhagic stroke patients. Most common electrolyte imbalance in ischaemic stroke was hyponatremia and most common electrolyte imbalance in Haemorrhagic stroke was hypokalemia. Statistically significant alteration were seen in total cholesterol, LDL and VLDL levels between haemorrhagic and ischaemic stroke. Conclusions: In the present study total cholesterol and HDL levels were higher in haemorrhagic stroke whereas triglycerides, LDL and VLDL were high in ischaemic stroke. Regular monitoring of lipid levels in patients with high risk factors for stroke patients will help in decreasing the mortality and morbidity. Future studies should be prospective, multi-centric and include a large sample size which will help in determining the association between electrolytes and lipid levels in stroke patients.

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Section: Discussionmentioning

confidence: 99%

A comparative study of serum electrolytes and lipid levels in ischaemic and haemorrhagic stroke

Wali

Patil

2016

Int J Res Med Sci

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A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?

Barber

McKeever

McDowell

et al. 2015

Brit J Clinical Pharma

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AimsHyponatraemia is one of the major adverse effects of thiazide and thiazide-like diuretics and the leading cause of drug-induced hyponatraemia requiring hospital admission. We sought to review and analyze all published cases of this important condition.MethodsOvid Medline, Embase, Web of Science and PubMed electronic databases were searched to identify all relevant articles published before October 2013. A proportions meta-analysis was undertaken.ResultsOne hundred and two articles were identified of which 49 were single patient case reports. Meta-analysis showed that mean age was 75 (95% CI 73, 77) years, 79% were women (95% CI 74, 82) and mean body mass index was 25 (95% CI 20, 30) kg m−2. Presentation with thiazide-induced hyponatraemia occurred a mean of 19 (95% CI 8, 30) days after starting treatment, with mean trough serum sodium concentration of 116 (95% CI 113, 120) mm and serum potassium of 3.3 (95% CI 3.0, 3.5) mm. Mean urinary sodium concentration was 64 mm (95% CI 47, 81). The most frequently reported drugs were hydrochlorothiazide, indapamide and bendroflumethiazide.ConclusionsPatients with thiazide-induced hyponatraemia were characterized by advanced age, female gender, inappropriate saliuresis and mild hypokalaemia. Low BMI was not found to be a significant risk factor, despite previous suggestions. The time from thiazide initiation to presentation with hyponatraemia suggests that the recommended practice of performing a single investigation of serum biochemistry 7–14 days after thiazide initiation may be insufficient or suboptimal. Further larger and more systematic studies of thiazide-induced hyponatraemia are required.

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Acute Hyponatremic Encephalopathy After a Cerebrovascular Accident

Cited by 2 publications

References 16 publications

A comparative study of serum electrolytes and lipid levels in ischaemic and haemorrhagic stroke

A comparative study of serum electrolytes and lipid levels in ischaemic and haemorrhagic stroke

A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?

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