Acute induction of inflammatory cytokine expression after γ-irradiation in the rat: Effect of an NF-κB inhibitor

Linard, Christine; Marquette, C.; Mathieu, Jacques; Pennequin, André; Clarençon, Didier; Mathé, Denis

doi:10.1016/j.ijrobp.2003.09.039

Cited by 169 publications

(114 citation statements)

References 35 publications

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“…An investigation using lung tissues of Wistar albino rats revealed that the activities of antioxidant enzymes including catalase (CAT) and superoxide dismutase (SOD) were decreased in the radiation only group compared with the saline (control) and radiation with CAPE (2) groups, indicating that CAPE (2) treatment with radiation therapy attenuated radiationinduced pulmonary injury in vivo, possibly by its antioxidant effect (Yildiz et al, 2008). CAPE (2) induced blockade of IR-induced NF-κB activation leading to suppression of several pro-inflammatory cytokines, including IL-1β, IL-6, and IL-8, and an increase of anti-inflammatory cytokines, including IL-10, thereby resulting in reduced inflammatory response to radiation (Linard et al, 2004).…”

Section: Caffeic Acid Phenethyl Ester (Cape)mentioning

confidence: 98%

Phenylpropanoids in radioregulation: double edged sword

2011

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Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

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Section: Caffeic Acid Phenethyl Ester (Cape)mentioning

confidence: 98%

Phenylpropanoids in radioregulation: double edged sword

2011

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“…Thus, the inhibition of one of these transcription factors with selective inhibitors is not sufficient for managing the upregulation of these cytokines following exposure to radiation (Linard et al 2004). Melatonin has an inhibitory effect on the NF-κB gene expression in stress situations such as irradiation (Lezoualc'h et al 1998;Mohan et al 1995).…”

Section: Effect Of Melatonin On Transcription Factors and Protein Kinmentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

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Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

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“…Overexpression of pro-inflammatory cytokines is often a sign of the onset of inflammation and has been characterized as an early effect of intestinal radiation [5] . To test whether fractionated irradiation induces a persistent and progressive inflammatory process, we assessed the expression of inflammatory mediators, relative to the housekeeping gene HPRT, in rat colon mucosa on D1 in irradiated rats in all 3 dose groups (16, 36 and 52 Gy) and on D3 in the 52 Gy group.…”

Section: Pattern Of Inflammatory Mediators During Fractionated γ Irramentioning

confidence: 99%

“…These "waves" of response may be interpreted as the result of failed attempts at adaptation and then later as the evidence of dysregulated tissue response. Recent studies show that irradiation induces the synthesis of various cytokines in several tissues, including the intestines [5] and lungs [6] . These cytokines lead to cell infiltration and fibroblast stimulation, thus enhancing collagen synthesis [7] .…”

Section: Introductionmentioning

confidence: 99%