Acute Infectious Gingivostomatitis

Infection with Virus of Herpes Simplex

“…Our knowledge of infection with the virus of herpes simplex has been greatly increased by observations made within recent years. Dodd, Johnson, and Buddingh (1938) showed that stomatitis in children was often a herpetic infection, and this work was confirmed and extended by Burnet and Williams (1939), by Scott, Steigman, and Convey (1941), and by Black (1942). Herpetic stomatitis is usually a primary infection occurring during the first six years of life, and antibodies to the virus of herpes simplex appear during convalescence (Burnet and Williams, 1939;Scott et al, 1941).…”

“…Dodd, Johnson, and Buddingh (1938) showed that stomatitis in children was often a herpetic infection, and this work was confirmed and extended by Burnet and Williams (1939), by Scott, Steigman, and Convey (1941), and by Black (1942). Herpetic stomatitis is usually a primary infection occurring during the first six years of life, and antibodies to the virus of herpes simplex appear during convalescence (Burnet and Williams, 1939;Scott et al, 1941). These primary infections are often associated with fever and some general constitutional disturbance, and groups of cases may occur in families Scott et al, 1941).…”

“…Herpetic stomatitis is usually a primary infection occurring during the first six years of life, and antibodies to the virus of herpes simplex appear during convalescence (Burnet and Williams, 1939;Scott et al, 1941). These primary infections are often associated with fever and some general constitutional disturbance, and groups of cases may occur in families Scott et al, 1941). After the primary infection in childhood persons seem to carry the virus for years and may suffer from recurrent attacks of labial herpes, althouLgh these subsequent manifestations are milder and are associated with relatively trivial symptoms.…”

Primary Generalized Infection Caused by Herpes Simplex Virus

“…It may be that when the primary infection with herpes virus gives rise to severe constitutional disturbance, as occasionally happens (Scott et al, 1941), there is a generalization of the virus, with viraemia. Ruchman and Dodd (1950) recovered virus from the blood in a case of herpetic rhinitis, although they failed in other primary herpetic infections.…”

Herpes Simplex Virus Type 2 Latency in the Footpad of Mice: Effect of Acycloguanosine on the Recovery of Virus

“…Primary exposure of individuals to herpes simplex virus (HSV) occurs early in life most often with HSV-1 (Scott et at., 1941). The incidence of primary genital infection with HSV-2 increases when sexual activity commences, and a significant proportion of the adult population has antibodies to HSV-2 (Nahmias et al, 1974).…”