Infection with Virus of Herpes Simplex

Herpesviruses.

“…Respiratory distress and bleeding are common features, but sometimes signs of CNS disturbance such as convulsions and raised intracranial pressure dominate the clinical picture (Hanshaw and Dudgeon, 1978). Primary infection with HSV-1 can become disseminated in previously healthy adults, but this is very rare (Kipping and Downie, 1948;Juel-Jensen, 1970). Generalised herpes presenting as acute hepatitis in an adult has also been described (Francis et al, 1972).…”

The Herpes Simplex Virus in Infantile Eczema

“…Eczema herpeticum-and in parallel eczema vaccinatum and the vaccinia virus-represents one of the primary manifestations of herpes simplex infection (Kipping and Downie, 1948;Blank, 1949;Brain et al, 1950) occurring in persons subject to a cutaneous allergic diathesis. It may well be regarded as a specific infectious disease with a short incubation period (Burnet and Williams, 1939).…”

“…It may well be regarded as a specific infectious disease with a short incubation period (Burnet and Williams, 1939). This infection normally occurs during childhood, and is not usually accompanied by severe reactions, though these sometimes occur (Kipping and Downie, 1948). The severity of these reactions may be due to anaphylaxis (Barker and Hallinger, 1947), although virus virulence, susceptibility of host, secondary infection, and the nature and extent of the preceding eruption are probably contributory factors (Lynch, 1945).…”

Recurrent Herpes Simplex

“…At times herpes simplex may become a generalized and occasionally fatal infection. 3 4 The majority of persons become infected with the virus before adult life is reached.5 6 Primary infections often assume the guise of acute aphthous stomatitis,7 or occur as a complication of infectious eczema (Kaposi's varicelliform eruption) . 8 To explain re-infections, which appear to occur without se-inoculation, it has been postulated that the virus remains latent in epithelial cells in and near the site of the original infection, usually the skin surrounding the mouth and the buccal mucous membrane.5' 9 There are a number of pathological and experimental observations to suggest that the herpes virus may invade by way of the nerves and reside within the central nervous system of man.…”