Acute Infectious Purpura Fulminans Caused by &lt;i&gt;Klebsiella oxytoca&lt;/i&gt;

Tsubouchi, Nobuhiko; Tsurukiri, Junya; Numata, Jushi; Sano, Hidefumi

doi:10.2169/internalmedicine.2350-18

Cited by 10 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…K. oxytoca is the second most prevalent Klebsiella in the clinic after K. pneumoniae ( Neog et al, 2021 ). Opportunistic K. oxytoca in hospitals mainly infects infants, the elderly, and patients with low immune function, and is the main cause of colitis, endocarditis, sepsis, and urinary and respiratory tract infections ( Beaugerie et al, 2003 ; Ménard et al, 2010 ; Egger et al, 2017 ; Tsubouchi et al, 2019 ; Soto-Hernández et al, 2020 ; Surani et al, 2020 ). The prevalence rate of K. oxytoca ranges from 2.3 to 24%, accounting for 13–24% of the total nosocomial bacteremia ( Watanakunakorn and Jura, 1991 ; Hansen et al, 1998 ; Manohar et al, 2017 ; Ahmad et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From Clinical Klebsiella oxytoca and Its Therapeutic Effect on Mice Bacteremia

Zhang

Yan

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

Klebsiella oxytoca is an important nosocomial and community-acquired opportunistic pathogenic Klebsiella and has become the second most prevalent strain in the clinic after K. pneumoniae. However, there have been few reports of bacteriophages used for treating K. oxytoca. In this study, a novel bacteriophage, vB_Kox_ZX8, which specifically infects K. oxytoca AD3, was isolated for the first time from human fecal samples. The biological characteristics of vB_Kox_ZX8 showed an incubation period of 10 min, a burst size of 74 PFU/cell, and a stable pH range of 3–11. Genomic bioinformatics studies of vB_Kox_ZX8 showed that it belongs to the genus Przondovirus, subfamily Studiervirinae, family Autographiviridae. The genome of vB_Kox_ZX8 is 39,398 bp in length and contains 46 putative open reading frames encoding functional proteins, such as DNA degradation, packaging, structural, lysin-holin, and hypothetical proteins. We further investigated the efficacy of vB_Kox_ZX8 phage in the treatment of mice with bacteremia caused by K. oxytoca infection. The results showed that vB_Kox_ZX8 (5 × 109 PFU/mouse) injected intraperitoneally alone was metabolized rapidly in BALB/c mice, and no significant side effects were observed in the control and treatment groups. Importantly, intraperitoneal injection with a single dose of phage vB_Kox_ZX8 (5 × 107 PFU/mouse) for 1 h post-infection saved 100% of BALB/c mice from bacteremia induced by intraperitoneal challenge with a minimum lethal dose of K. oxytoca AD3. However, all negative control mice injected with PBS alone died. Owing to its good safety, narrow host infectivity, high lysis efficiency in vitro, and good in vivo therapeutic effect, phage vB_Kox_ZX8 has the potential to be an excellent antibacterial agent for clinical K. oxytoca-caused infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From Clinical Klebsiella oxytoca and Its Therapeutic Effect on Mice Bacteremia

Zhang

Yan

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Although PF is a thrombotic disorder notorious for its cutaneous hallmarks, it is frequently complicated by shock, DIC, and multisite thromboses. [3,4] In the case reported herein, the clinical manifestations of acute-onset fever and hypotension rapidly progressed into septic shock, followed by the appearance of skin lesions and coagulation dysfunction, supporting a differential diagnosis of PF complicated by DIC. Contrast-enhanced computed tomography imaging of the abdomen was performed to determine the cause of the abdominal distension, the results of which revealed large-vessel venous thrombosis.…”

Section: Discussionmentioning

confidence: 53%

Acute infectious purpura fulminans: case report of a medical emergency

Sun

et al. 2022

Emerg Crit Care Med

View full text Add to dashboard Cite

Background: Purpura fulminans (PF), characterized by the sudden onset of large, rapidly spreading hemorrhagic skin infarctions and associated disseminated intravascular coagulation, is an uncommon medical emergency. Early recognition, prompt antibiotic therapy, and intensive supportive care are essential to reduce the mortality rate of this disease.Case Presentation: We report the case of a 28-year-old Chinese man with acute infectious PF. He initially presented with a fever, which rapidly progressed to septic shock, followed by skin lesions and disseminated intravascular coagulation. Computed tomography imaging revealed superior and inferior mesenteric vein thromboses. Although the etiology of the patient's infection was unclear, the patient received early fluid resuscitation, empiric antibiotic therapy, and blood product replacement, which resulted in gradual clinical improvement.Conclusion: Sepsis-associated PF may be reversible with timely empirical therapeutic interventions; however, the severity of PF should not be underestimated, and treatment should be tailored to individual patients.

show abstract

“…and varicella-zoster virus. 2,[7][8][9][10][11][12][13] Two earlier cases associated with Capnocytophaga were characterized by concomitant renal failure, metabolic acidosis, hemolytic anemia, and DIC. 14 It is estimated that Capnocytophaga causes 11% to 46% of all cases of sepsis 15 ; sepsis resulting from Capnocytophaga has extremely poor outcomes, with mortality reaching as high as 60%.…”

Section: A B Cmentioning

confidence: 99%

Purpura Fulminans in an Asplenic Intravenous Drug User

Nyers¹

2021

Cutis

View full text Add to dashboard Cite

Capnocytophaga species are fastidious, slowgrowing microorganisms. It is important, therefore, to maintain a high degree of suspicion and alert the microbiology laboratory to increase the likelihood of isolation.• Patients should be cautioned regarding the need for prophylactic antibiotics in the event of an animal bite; asplenic patients are at particular risk for infection.• In patients with severe purpura fulminans and a gangrenous limb, it is important to allow adequate time for demarcation of gangrene and not rush to amputation.

show abstract

Acute Infectious Purpura Fulminans Caused by <i>Klebsiella oxytoca</i>

Cited by 10 publications

References 2 publications

Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From Clinical Klebsiella oxytoca and Its Therapeutic Effect on Mice Bacteremia

Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From Clinical Klebsiella oxytoca and Its Therapeutic Effect on Mice Bacteremia

Acute infectious purpura fulminans: case report of a medical emergency

Purpura Fulminans in an Asplenic Intravenous Drug User

Contact Info

Product

Resources

About