2021
DOI: 10.1080/08958378.2021.2013348
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Acute inhalation toxicity of aerosolized electrochemically generated solution of sodium hypochlorite

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Cited by 11 publications
(8 citation statements)
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“…By diluting the last solution in a ratio of 1:1 with purified water, we obtain a high‐purity isotonic solution of 500 mg L −1 NaClO, in which the content of NaClO 3 will be near 5 mg L −1 . Such isotonic solutions of sodium hypochlorite are suitable for use in medicine as infusion drugs 16,17 …”
Section: Resultsmentioning
confidence: 99%
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“…By diluting the last solution in a ratio of 1:1 with purified water, we obtain a high‐purity isotonic solution of 500 mg L −1 NaClO, in which the content of NaClO 3 will be near 5 mg L −1 . Such isotonic solutions of sodium hypochlorite are suitable for use in medicine as infusion drugs 16,17 …”
Section: Resultsmentioning
confidence: 99%
“…Also recently, the scope of medical application of such compounds has significantly expanded: they are used in the treatment of skin diseases, 11 wounds (including purulent ones), 12 in efferent therapy (‘indirect electrochemical detoxification’), 13 including for oncological therapy 14 . The use of hypochlorites in the prevention and treatment of aerogenic infectious diseases of various etiologies also has great prospects, 15 while the low toxicity in the applied concentrations makes it possible to administer them both intravenously and via inhalations 16,17 . In addition, hypochlorite solutions are used for the synthesis of ‘softer’ chlorine‐active compounds for medical purposes (for example, N ‐chlorotaurines), 18 as well as for microbicidal polymers, which, in turn, can be used as components of dressings, personal protective equipment, water and air filters, etc 19,20 …”
Section: Introductionmentioning
confidence: 99%
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“…The use of NaOCl solutions in commercially available prepackaged products is often preferred over aqueous HOCl solutions produced in-situ because of their long-term stability – years (NaOCl) vs months (HOCl). A study by Murashevych et al [ 29 ] with 30 laboratory animals (mature Wistar Han rats) found no negative tissue or health effects after exposing the animals to a single inhalation exposure of NaOCl solution. They concluded: “The data obtained allow classifying such solution to the 4 th (or even 5 th – after additional studies) class of toxicity in accordance with Globally Harmonized System of Classification and Labeling of Chemicals” [ 29 ], [ 30 ].…”
Section: Hocl – Physicochemical Propertiesmentioning
confidence: 99%
“…A study by Murashevych et al [ 29 ] with 30 laboratory animals (mature Wistar Han rats) found no negative tissue or health effects after exposing the animals to a single inhalation exposure of NaOCl solution. They concluded: “The data obtained allow classifying such solution to the 4 th (or even 5 th – after additional studies) class of toxicity in accordance with Globally Harmonized System of Classification and Labeling of Chemicals” [ 29 ], [ 30 ]. The used concentration of 1.7 mg/m 3 is 340% above the legal limit of HOCl exposure for humans and about 17-fold the concentration in ‘standard’ inhalation experiments with HOCl.…”
Section: Hocl – Physicochemical Propertiesmentioning
confidence: 99%