Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat

Cook, Elisabeth; Preece, Jacqueline A.; Tobin, Simon; Sugden, Mary C.; Cox, Dimity J.; Palmer, T.N.

doi:10.1042/bj2540059

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…It is possible that we were unable to detect a true impairment of glycogen storage after large amounts of alcohol because of individual responses in difference subjects or because the fiber-type specificity of response was masked in a mixed muscle sample, as seen in rat studies (8). Further studies are needed to investigate the possibility of direct effects of alcohol on glycogen synthesis in individual subjects or specific muscle fibers.…”

Section: Discussionmentioning

confidence: 94%

“…Rat studies have shown that the infusion of ethanol causes the impairment of glycogen deposition in the liver and selective muscle fiber types during CHO feeding of previously starved animals (8,(32)(33)(34) and during the immediate recovery from high-intensity exercise associated with high muscle and plasma lactate levels (24). These effects of ethanol have been reported in oxidative but not nonoxidative fiber types (32-34) but were not observed in mixed muscle samples (8).…”

Section: Discussionmentioning

confidence: 97%

“…These effects of ethanol have been reported in oxidative but not nonoxidative fiber types (32-34) but were not observed in mixed muscle samples (8). One observed mechanism to explain the impairment of glycogen synthesis in oxidative muscle types was a Values are means Ϯ SE for 6 subjects in the 8-h study and 9 subjects in the 24-h study, * alcohol displacement Ͻ control and alcohol ϩ CHO (P Ͻ 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…In humans, ingestion of alcohol has been shown to inhibit glucose uptake into skeletal muscle (17), decrease the stimulatory effect of exercise on muscle glucose uptake (18), and impair glucose utilization (25). Rat studies have shown that intragastric administration of alcohol interferes with glycogen synthesis in the liver (8) and oxidative skeletal muscle fibers (32,34) in response to glucose refeeding after starvation. Glycogen storage during 30 min of recovery from high-intensity exercise was also impaired in oxidative but not nonoxidative fibers of rat skeletal muscle by alcohol administration (24).…”

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confidence: 99%

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Effect of alcohol intake on muscle glycogen storage after prolonged exercise

Burke

Collier²,

Broad³

et al. 2003

Journal of Applied Physiology

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We studied the effects of alcohol intake on postexercise muscle glycogen restoration with samples from vastus lateralis being collected immediately after glycogen-depleting cycling and after a set recovery period. Six well-trained cyclists undertook a study of 8-h recovery (2 meals), and another nine cyclists undertook a separate 24-h protocol (4 meals). In each study, subjects completed three trials in crossover order: control (C) diet [meals providing carbohydrate (CHO) of 1.75 g/kg]; alcohol-displacement (A) diet (1.5 g/kg alcohol displacing CHO energy from C) and alcohol + CHO (AC) diet (C + 1.5 g/kg alcohol). Alcohol intake reduced postmeal glycemia especially in A trial and 24-h study, although insulin responses were maintained. Alcohol intake increased serum triglycerides, particularly in the 24-h study and AC trial. Glycogen storage was decreased in A diets compared with C at 8 h (24.4 +/- 7 vs. 44.6 +/- 6 mmol/kg wet wt, means +/- SE, P < 0.05) and 24 h (68 +/- 5 vs. 82 +/- 5 mmol/kg wet wt, P < 0.05). There was a trend to reduced glycogen storage with AC in 8 h (36.2 +/- 8 mmol/kg wet wt, P = 0.1) but no difference in 24 h (85 +/- 9 mmol/kg wet wt). We conclude that 1). the direct effect of alcohol on postexercise glycogen synthesis is unclear, and 2). the main effect of alcohol intake is indirect, by displacing CHO intake from optimal recovery nutrition practices.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of alcohol intake on muscle glycogen storage after prolonged exercise

Burke

Collier²,

Broad³

et al. 2003

Journal of Applied Physiology

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“…Nevertheless, intragastric (i.g.) dosage regimes for acute studies have also been used with much success (Cook et al, 1988).…”

Section: Acute Studiesmentioning

confidence: 99%

Ethanol dosage regimes in studies of ethanol toxicity: influence of nutrition and surgical interventions

Preedy¹,

McIntosh²,

Bonner³

et al. 1996

Addiction Biology

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In this review we consider some of the practical facets of acute and chronic drug regimes. In particular, we illustrate our arguments with specific reference to alcohol and draw attention to methodological constraints that might alter biochemical or physiological processes. These includes the imposition of nutritional abnormalities and surgical procedures. These two areas are highlighted because there is evidence to show that they have marked influences on metabolic parameters, exemplified by tissue protein synthesis. In general, there is no controversy as to methods for acute studies with alcohol, although some reports have failed to investigate whether intravenous, intragastric or intraperitoneal regimes more accurately mimic the clinical situation. With regard to chronic feeding regimes, evidence is provided to support the argument that, currently, the most appropriate feeding protocol ensures that both control and treated groups receive identical amounts of nutrients albeit with differences in the calories apportioned to ethanol, which is substituted by isocaloric glucose or other carbohydrates in controls. However, there are still other methods being employed: these are subject to misinterpretation as the principle of ensuring that control and ethanol-fed rats receive identical amounts of nutrients, is ignored. In this review we also draw attention to the fact that surgical procedures, which are often employed to facilitate the measurement of body parameters (for example, implantation of cannulae), themselves alter tissue metabolism. The importance of this relates to the concept of metabolic superimposition, which implicates interacting responses when two or more stresses (i.e. surgery and drug administration) are superimposed.

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Skeletal Muscle Toxicology

Kenaston¹,

Abramson²,

Pfeiffer³

et al. 2009

General, Applied and Systems Toxicology

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The skeletal musculature is necessary for normal motor functions such as walking or breathing. It accounts for between 35 and 45% of total body weight in humans and is the most energetically demanding tissue in the body. Skeletal muscle is a unique tissue with intricate organizational arrangement, requiring precise regulation of intracellular ions and cooperation by a multitude of cellular proteins. As a result, it also has susceptibilities to a diverse array of toxic insults. Derangements of skeletal muscle function can cause loss of movement, multiorgan involvement and even organismal demise. In addition to direct effects on skeletal muscle, this tissue can also be responsible for damage to distant tissues and organs by release of large intracellular proteins into the vasculature. As a specific topic, skeletal muscle toxicology has been largely absent from the majority of textbooks. However, it represents an important and specific target of a variety of natural and synthetic toxicants. Here we present an overview of skeletal muscle physiology, including tissue architecture, energetic substrate preferences, and function. Laboratory methods and diagnostic observations to be used for investigating skeletal muscle injury in a research and clinical setting are also discussed. Finally, we provide an in‐depth outline of skeletal muscle toxicants arranged according to their proposed mechanism of action.

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Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat

Cited by 17 publications

References 26 publications

Effect of alcohol intake on muscle glycogen storage after prolonged exercise

Effect of alcohol intake on muscle glycogen storage after prolonged exercise

Ethanol dosage regimes in studies of ethanol toxicity: influence of nutrition and surgical interventions

Skeletal Muscle Toxicology

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