Acute interstitial nephritis induced by Solanum nigrum

Oh, Sung Sik; Choi, Myung Woo; Choi, Mi Rim; Lee, Jong Hwa; Yang, Hyun; Choi, Yeong Jin; Cho, A Young; Lee, Kwang Young; Sun, In O

doi:10.1016/j.krcp.2016.05.003

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…S. nigrum has been reported to have dose-dependent toxic effects, resulting in nausea, vomiting, diarrhea, dizziness, headache, fever, sweating, tachycardia, loss of speech, blindness, mental confusion, coma, and death [ 80 , 81 ]. A recent study reported that a patient suffered acute interstitial nephritis following the ingestion of S. nigrum and was successfully treated using corticosteroid therapy [ 81 ]. S. nigrum toxicity is mainly attributed to the presence of glycoalkaloids, including solanine, solasonine, and solamargine, which constitute the plant’s primary natural defenses, as these compounds are toxic even at relatively low quantities [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer

Dong

Hao

Fang

et al. 2021

BMC Complement Med Ther

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Background Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective mechanisms of this activity of the plant. Thus, this study aimed to perform a systematic analysis and to predict the potential action mechanisms underlying S. nigrum activity in BC based on network pharmacology. Methods Based on network pharmacology, the active ingredients of S. nigrum and the corresponding targets were identified using the Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform database, and BC-related genes were screened using GeneCards and the Online Mendelian Inheritance in Man database. In addition, ingredient-target (I–T) and protein–protein interaction (PPI) networks were constructed using STRING and Cytoscape, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted, and then the pathways directly related to BC were integrated manually to reveal the pharmacological mechanism underlying S. nigrum-medicated therapeutic effects in BC. Results Seven active herbal ingredients from 39 components of S. nigrum were identified, which shared 77 common target genes related to BC. I-T network analysis revealed that quercetin was associated with all targets and that NCOA2 was targeted by four ingredients. Besides, interleukin 6 had the highest degree value in the PPI network, indicating a hub role. A subsequent gene enrichment analysis yielded 86 significant GO terms and 89 significant pathways, implying that S. nigrum had therapeutic benefits in BC through multi-pathway effects, including the HIF-1, TNF, P53, MAPK, PI3K/Akt, apoptosis and bladder cancer pathway. Conclusions S. nigrum may mediate pharmacological effects in BC through multi-target and various signaling pathways. Further validation is required experimentally. Network pharmacology approach provides a predicative novel strategy to reveal the holistic mechanism of action of herbs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer

Dong

Hao

Fang

et al. 2021

BMC Complement Med Ther

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“…Active phytoconstituents of this polyherbal decoction is supposed to have high affinity to the spike protein of the COVID‐19 virus and hence prevents its binding to the ACE2 receptor on the host cell. 7 , 8 Among the constituents, Syzygium aromaticum , 9 Solanum anguivi , 10 Andrographis paniculata 11 and Cyperus rotundus 12 have been known to produce various degrees of nephrotoxicity according to case reports and series.…”

Section: Discussionmentioning

confidence: 99%

Traditional medicines prescribed for prevention of COVID‐19: Use with caution

et al. 2021

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Acute interstitial nephritis can result due to exposure to any medication, toxins, infections or malignancy. In the midst of this Coronavirus (COVID‐19) pandemic, there has been a race for finding remedies to prevent the spread of and control the complications due to Severe Acute Respiratory Syndrome Coronavirus 2. Certain Indian medicinal herb concoctions like kabasura kudineer and nilavembu kudineer are being widely publicized to boost immunity and reduce the risk of developing COVID‐19. Little knowledge exists about the adverse effects of these herbal remedies. We report two patients who presented to us with vague complaints following the ingestion of kabasura kudineer and we diagnosed them with acute tubulointerstitial nephritis (ATIN). The temporal relationship of ingestion of these remedies to the development of ATIN calls for vigilance and caution with regular monitoring of renal functions especially in those with chronic kidney disease.

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“…is a commonly used traditional herbal plant used for various ailments, and it is well known for its therapeutic properties and traditional Indian medicine. Solanum Nigrum belongs to the Solanaceae family (Oh et al, 2016), also known by Black nightshade or Makoi (Kumar et al, 2019 ;Shivappa et al, 2019 ;Mohamed Saleem et al, 2009) , is an annual, branched, short-lived herb found in forested areas and disturbed habitats (Chauhan et al, 2012;Teklehaimanot et al, 2015). The height of the plant is between 30-120 cm.…”

Section: Introductionmentioning

confidence: 99%

A Sneak peek (1970-2021) Into Phytochemistry and Ethnomedical Properties of Solanum Nigrum Linn (Makoi)

Goel¹,

Ahmed²,

Singh³

et al. 2022

Journal of Pharmaceutical Negative Results

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Introduction: Plants have always played a substantial role in the traditional medicine system worldwide. In India and other parts of theworld, Solanum Nigrum Linn. is one of the most promising and reliable sources of medicine in the traditional medicine system. It iswell known for its dynamic therapeutic properties. The concrete objective of selecting this plant is to consolidate its bioactive elementsand possibly medicinal qualities. So that future scientists and researchers may progress novel pharmaceuticals for pre-clinical andclinical trials, which could be launched as new targeted therapeutic options.Method: This review summarized the previous three decades' worth of scientific publications from online databases such as GoogleScholar, PubMed, ScienceDirect, Web of Science, and library books to assemble their possible phytopharmacological and therapeuticpotentials.Results: From the ongoing research database, S. Nigrum possesses a plethora of active phytoconstituents like glycoproteins,polysaccharides, polyphenolic compounds, and glycoalkaloids which are responsible for various pharmacological activities such asantioxidant, anticancer, antitumor, hepatoprotective, antidiabetic, and anti-asthmatic etc.Conclusion: This mystic herb has exhibited numerous ethnomedical properties in humans. Our research findings provide clear evidencethat S. Nigrum could be a potential natural source of several ailments and might be marketed as an alternative to contemporarymedicines. The stem, flower, root, and seed contain numerous dynamic bioactive constituents that are unexplored. Future researchershave an excellent opportunity to investigate them and elucidate their biomedical scientific activities and mechanisms in differentdiseases.

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Acute interstitial nephritis induced by Solanum nigrum

Cited by 5 publications

References 6 publications

A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer

A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer

Traditional medicines prescribed for prevention of COVID‐19: Use with caution

A Sneak peek (1970-2021) Into Phytochemistry and Ethnomedical Properties of Solanum Nigrum Linn (Makoi)

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