Acute intravascular haemolysis associated with cephalexin therapy

Forbes, C.D.; Craig, James A.; Mitchell, RM; McNicol, G. P.

doi:10.1136/pgmj.48.557.186

Cited by 36 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For unknown reasons, semisynthetic penicillins and cephalosporins have been found to cause hemo lysis much less frequently than penicillin G [3][4][5][6][7][8]. Be sides a sufficient coating of RBC, very high titers of circulating drug-specific antibodies -mostly of the IgG type -appear to be a prerequisite for inducing hemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of the cases the DAT is exclusively positive with monospecific anti-IgG an tiglobulin serum, but in a minority anti-C3 or antiIgM showed positive results too [1,2]. The indirect an tiglobulin test (IAT; i.e., patient's serum added to nor mal donor RBC) is only positive with penicillincoated RBC, but negative with untreated cells [1], Be sides penicillin G this type of hemolysis has rarely been reported with some semisynthetic penicillins and some cephalosporins [3][4][5][6][7][8]. We have recently in vestigated a patient in whom a severe immune hemo lytic anemia was induced by amoxicillin which so far has never been incriminated in this particular type of adverse reaction.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amoxicillin-Induced Immune Hemolysis

1985

View full text Add to dashboard Cite

Severe hemolysis occurred in a 51-year-old female after a 17-day course of intravenous amoxicillin. A strongly positive direct antiglobulin test (anti-IgG titer 1:2,000) ensued which disappeared after withdrawal of the drug. Both the patient’s serum and eluate obtained from the patient’s red cells contained an IgG antibody which reacted with red blood cells coated in vitro with amoxicillin, but not with uncoated cells. In addition, high-titer antipenicillin, antiampicillin and antiamoxicillin IgG antibodies could be demonstrated in her serum by a RAST-based solid-phase radioimmunoassay. The patient’s hemolysis gradually subsided within 1 week after discontinuing the drug. This is the first report of amoxicillin-induced immune hemolytic anemia

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amoxicillin-Induced Immune Hemolysis

1985

View full text Add to dashboard Cite

show abstract

“…commun.]. Several other reports suggest that this may also have occurred with penicillin [9][10][11][12], There was no evidence for other causes of the acute hemolytic episode in this patient. The patient's serum did not contain warm autoantibodies (e.g.…”

Section: Resultsmentioning

confidence: 58%

Erythromycin-Induced Immune Hemolytic Anemia

Nance¹,

Ladisch²,

Williamson³

et al. 1988

Vox Sanguinis

View full text Add to dashboard Cite

A 3-year-old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug-dependent antibodies could be demonstrated with an in vitro ‘immune-complex’ method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin-coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug-dependent hemolysis was demonstrable

show abstract

“…Hemolytic anemia following the administration of cephalosporin antibiotics is rare and has only been described for cephalothin [3-51, cephaloridine [6], cephalexin [7], and cefazolin [ 5 ] . We now report a case of severe hemolytic anemia following the administration of intravenous cefamandole and provide evidence that anticefamandole was responsible for the hemolytic episode.…”

Section: Introductionmentioning

confidence: 99%

Extravascular hemolysis following the administration of cefamandole

et al. 1985

View full text Add to dashboard Cite

Hemolytic anemia occurred in a 70-year-old female after a five-day course of intravenous cefamandole. The patient's serum contained an IgG antibody which was reactive with red blood cells which had been coated in vitro with cefamandole but not with uncoated cells. An in vitro assay of allogeneic mononuclear phagocytosis of cefamandole-coated red cells sensitized with the patient's anti-cefamandole indicated that the anti-cefamandole could induce significant phagocytosis. The anti-cefamandole was easily inhibited in vitro by cefamandole as well as by a variety of related cephalosporins indicating broad cross-reactivity, with the antigenic site primarily the 7-amino-cephalosporanic acid nucleus. Penicillins could inhibit the anti-cefamandole but only when using concentrations 3-10 X those of cephalosporins. Eleven examples of anti-penicillin tested failed to react with cefamandole-coated red cells. Screening of 344 random sera from hospitalized patients found only five (1.5%) reactive with cefamandole-coated red cells; three of these sera were also reactive with penicillin-coated red cells. The patient's hemolysis subsided following cessation of the drug. This is the first report of anti-cefamandole-induced hemolytic anemia.

show abstract

Acute intravascular haemolysis associated with cephalexin therapy

Cited by 36 publications

References 11 publications

Amoxicillin-Induced Immune Hemolysis

Amoxicillin-Induced Immune Hemolysis

Erythromycin-Induced Immune Hemolytic Anemia

Extravascular hemolysis following the administration of cefamandole

Contact Info

Product

Resources

About