Acute kidney injury associated with Plasmodium malariae infection

Badiane, Aïda Sadikh; Diongue, Khadim; Diallo, Seydou; Ndongo, Aliou Abdoulaye; Diédhiou, Cyrille K.; Déme, Awa B.; Ma, Diallo; Ndiaye, Mouhamadou; Seck, Mame Cheikh; Dieng, T; Ndir, O.; Mboup, Souleymane; Ndiaye, Daouda

doi:10.1186/1475-2875-13-226

Cited by 28 publications

(30 citation statements)

References 17 publications

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“…falciparum accounts for the misdiagnosis of these species. There have been case study reports of treatment failures [ 21 ] and acute renal injury [ 22 ] attributable to undiagnosed P . malariae infection or co-infection.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of Plasmodium species infections in Zimbabwean population

Amanfo

Mduluza

Midzi

et al. 2016

Malar J

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BackgroundIndividuals living in malaria-endemic regions may be exposed to more than one Plasmodium species; there is paucity of data on the distribution of the different species of Plasmodium in affected populations, in part due to the diagnostic method of microscopy, which cannot easily differentiate between the species. Sero-epidemiological data can overcome some of the shortcomings of microscopy.MethodsThe specificity of IgG antibodies to recombinant merozoite surface protein 1 (MSP-119) derived from four human Plasmodium species (Plasmodiumfalciparum, Plasmodiumvivax, Plasmodiummalariae, Plasmodiumovale) was investigated using competition enzyme-linked immunosorbent assay. Subsequently, these antigens were used to determine the exposure prevalence to the different Plasmodium species in serum samples of participants. One-hundred individuals, aged five-18 years, from each of the three Plasmodium meso-endemic Zimbabwean villages (Burma Valley, Mutoko, Chiredzi) were recruited in the study.ResultsThe study demonstrated that the host serum reactivity to MSP-119 antigens was species-specific and that no cross-reactivity occurred. The overall prevalence of antibody response to MSP-119 antigens was 61 % in Burma Valley, 31 % in Mutoko and 32 % in Chiredzi. Single species IgG responses to MSP-119 were most frequent against P. falciparum, followed by P. malariae and P. ovale, with responses to P. vivax being the least prevalent. Interestingly, 78–87 and 50 % of sera with IgG responses to P. malariae and P. ovale MSP-119, respectively, also had IgG specific response for P. falciparum MSP-119 antigens, indicating that exposure to these species is a common occurrence in these populations. Single species IgG responses to the non-falciparum species were at a very low frequency, ranging between 0 and 13 % for P. malariae.ConclusionsThere is evidence of a higher exposure to the non-falciparum parasite species than previously reported in Zimbabwe. The recombinant MSP-119 antigens could be used as additional diagnostic tools in antibody assays for the detection of exposure to the different Plasmodium species. The results also introduce an interesting concept of the co-infection of non-falciparum Plasmodium almost always with P. falciparum, which requires further validation and mechanistic studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-016-1325-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Seroepidemiology of Plasmodium species infections in Zimbabwean population

Amanfo

Mduluza

Midzi

et al. 2016

Malar J

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“…While previous reports in Sénégal have indicated low or reduced incidence of these species [4, 5], there are limited data from other regions of the country, and it remains unknown if these observations can be generalized nationwide. Furthermore, P. malariae is relatively under-reported in these regions [6]. Recently, multiple clinical cases of P. vivax infection were detected in Sénégal [7].…”

Section: Introductionmentioning

confidence: 99%

Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal

Daniels

Déme

Gomis

et al. 2017

Malar J

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BackgroundExpanded malaria control efforts in Sénégal have resulted in increased use of rapid diagnostic tests (RDT) to identify the primary disease-causing Plasmodium species, Plasmodium falciparum. However, the type of RDT utilized in Sénégal does not detect other malaria-causing species such as Plasmodium ovale spp., Plasmodium malariae, or Plasmodium vivax. Consequently, there is a lack of information about the frequency and types of malaria infections occurring in Sénégal. This study set out to better determine whether species other than P. falciparum were evident among patients evaluated for possible malaria infection in Kédougou, Sénégal.MethodsReal-time polymerase chain reaction speciation assays for P. vivax, P. ovale spp., and P. malariae were developed and validated by sequencing and DNA extracted from 475 Plasmodium falciparum-specific HRP2-based RDT collected between 2013 and 2014 from a facility-based sample of symptomatic patients from two health clinics in Kédougou, a hyper-endemic region in southeastern Sénégal, were analysed.Results Plasmodium malariae (n = 3) and P. ovale wallikeri (n = 2) were observed as co-infections with P. falciparum among patients with positive RDT results (n = 187), including one patient positive for all three species. Among 288 negative RDT samples, samples positive for P. falciparum (n = 24), P. ovale curtisi (n = 3), P. ovale wallikeri (n = 1), and P. malariae (n = 3) were identified, corresponding to a non-falciparum positivity rate of 2.5%.ConclusionsThese findings emphasize the limitations of the RDT used for malaria diagnosis and demonstrate that non-P. falciparum malaria infections occur in Sénégal. Current RDT used for routine clinical diagnosis do not necessarily provide an accurate reflection of malaria transmission in Kédougou, Sénégal, and more sensitive and specific methods are required for diagnosis and patient care, as well as surveillance and elimination activities. These findings have implications for other malaria endemic settings where species besides P. falciparum may be transmitted and overlooked by control or elimination activities.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-016-1661-3) contains supplementary material, which is available to authorized users.

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“…9 The diagnosis of acute kidney injury has been established on the basis of clinical evidence (anuria) and biochemical characteristics (azotemia, hyponatremia, and hypokalemia). 2,7,10 The reported polyuria is a classic evolution of diuresis during treatment of acute kidney injury and is due to recovery from fluid retention, which may be likened to the removal of an obstacle. 10 Hepatic involvement revealed by cytolysis has been reported by some authors.…”

Section: Discussionmentioning

confidence: 99%

“…Acute kidney injury is, however, well known in adults and, in particular, in nonimmune subjects with P. falciparum malaria infections. 2,7 Furthermore, P. falciparum is recognized as an important cause of acute kidney injury in areas of intense transmission. 4 The incidence of malarial acute kidney injury worldwide is 1-4% and may be as high as 60% among nonimmune adults from nonendemic regions visiting malaria-endemic regions of the world.…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury in a shepherd with severe malaria: a case report

Boushab¹,

Fall-Malick

Savadogo

et al. 2016

IJNRD

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Malaria is one of the main reasons for outpatient consultation and hospitalization in Mauritania. Although four Plasmodium species, ie, Plasmodium (P.) falciparum, P. vivax, P. malariae, and P. ovale, cause malaria in Mauritania, recent data on their frequency is lacking. Since infections with P. falciparum generally result in serious disease, their identification is important. We report a case of oliguric renal injury associated with malaria in a 65-year-old shepherd. Clinical manifestations included anemia, oliguria, and elevated creatinine and urea. The rapid diagnostic test for malaria and microscopic examination of blood smears were positive for P. falciparum. On the basis of this, the patient was diagnosed as having acute kidney injury as a complication of severe malaria. The patient was treated for malaria with intravenous quinine for 4 days, followed by 3 days of oral treatment. Volume expansion, antipyretic treatment, and diuretics were administered. He also had two rounds of dialysis after which he partially recovered renal function. This outcome is not always the rule. Prognosis depends much on early diagnosis and appropriate supportive treatment.

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Acute kidney injury associated with Plasmodium malariae infection

Cited by 28 publications

References 17 publications

Seroepidemiology of Plasmodium species infections in Zimbabwean population

Seroepidemiology of Plasmodium species infections in Zimbabwean population

Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal

Acute kidney injury in a shepherd with severe malaria: a case report

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