Acute Kidney Injury Caused by Zonisamide-Induced Hypersensitivity Syndrome

Fujita, Yoshiro; Hasegawa, Midori; Nabeshima, Kuihiro; Tomita, Makoto; Murakami, Kazutaka; Nakai, Shigeru; Yamakita, Takashi; Matsunaga, Kayoko

doi:10.2169/internalmedicine.49.2451

Cited by 26 publications

(17 citation statements)

References 18 publications

(7 reference statements)

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“…Fever was present in all patients described in these reports. Edema, predominantly on the face, was observed with a relatively high frequency [35, 37, 39–44, 47–49, 52], as were lymphadenopathy [35, 36, 39, 41–43, 45, 46, 49–51], hypereosinophilia [35–40, 42–52], and atypical lymphocytes [35, 36, 38–40, 42, 44, 46, 47, 52]. Internal organ involvement manifested itself largely as liver dysfunction, with elevated levels of liver enzymes [35–46, 48–50, 52] and cholestatic hepatitis with hepatocellular insufficiency [51].…”

Section: Resultsmentioning

confidence: 99%

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The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

Pritchett

Nanau

Neuman

2012

International Journal of Hepatology

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Background. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and further complication of therapy and recovery and (ii) to supplement the already available data on reporting frequencies of liver- or skin-induced cases with knowledge of individual case reports, including HHV-6 reactivation and briefly introducing chromosomally integrated HHV-6. Data Sources and Extraction. Drugs identified as causes of (i) idiosyncratic reactions, (ii) drug-induced hypersensitivity, drug-induced hepatotoxicity, acute liver failure, and Stevens-Johnson syndrome, and (iii) human herpes virus reactivation in PubMed since 1997 have been collected and discussed. Results. Data presented in this paper show that HHV-6 reactivation is associated with more severe organ involvement and a prolonged course of disease. Conclusion. This analysis of HHV-6 reactivation associated with drug-induced severe cutaneous reactions and hepatotoxicity will aid in causality assessment and clinical diagnosis of possible life-threatening events and will provide a basis for further patient characterization and therapy.

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Section: Resultsmentioning

confidence: 99%

“…Multiple organ failure was observed in a couple of studies [47, 51], one of which resulted in death [47]. Hypogammaglobulinemia, another symptom of DIHS, was observed in a number of studies as well [35, 38, 39, 45, 49]. …”

Section: Resultsmentioning

confidence: 99%

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

Pritchett

Nanau

Neuman

2012

International Journal of Hepatology

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“…For example, zonisamide is a better choice for overweight patients and safer than sodium valproate in patients prone to hepatic failure. On the other hand, for patients with history of renal impairment, renal stones, or high levels of creatinine or blood urea nitrogen (BUN), zonisamide should not be prescribed (20, 21). Although the prevalence of these side effects are low (as shown in this study), harmful complications such as hepatic failure, pancreatitis, and renal impairment should be considered seriously before prescription.…”

Section: Discussionmentioning

confidence: 99%

Comparing Zonisamide With Sodium Valproate in the Management of Migraine Headaches: Double-Blind Randomized Clinical Trial of Efficacy and Safety

Assarzadegan¹,

Tabesh²,

Hosseini-Zijoud³

et al. 2016

Iran Red Crescent Med J

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BackgroundMigraine is one of the most debilitating medical conditions and has a high socioeconomic burden. As conventional therapeutic methods do not entirely alleviate the symptoms, new alternatives are being considered.ObjectivesThis study evaluates the efficacy and safety of zonisamide compared with sodium valproate in the management of migraine headaches.Patients and MethodsIn the current double-blind, parallel, randomized, controlled trial, 96 patients with a migraine diagnosis based on the international headache society (HIS) criteria were selected. They were divided randomly into two groups; the case group was given zonisamide, and sodium valproate was given to a control group. In addition to the side effects of the drugs, the severity, duration, and frequency of migraine attacks were evaluated at baseline and at three months.ResultsThe 96 selected patients were divided randomly into two treatment groups (zonisamide n = 48, sodium valproate n = 48). Seven patients were excluded from analysis because of early dropout, leaving 89 (n = 45; n = 44) patients for analysis. While using zonisamide, six (13%) patients complained of fatigue, and two (4%) patients encountered noticeable appetite and weight loss. In the control group, five (11%) patients reported dizziness, and four (9%) patients faced obvious appetite and weight gain. Both drugs were considerably efficient in reducing further attacks. There was no statistically significant correlation between frequency or severity of migraine attacks and the drug used for treatment in three months of follow-up.ConclusionsBoth medications are effective in reducing migraine attacks. It will be important to consider the drugs’ adverse effects and availability and patients’ medical and socioeconomic condition to select the appropriate treatment.

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“…Риск осложнений со стороны почек и нефролити-аза многократно повышается при комбинации препа-ратов, ингибирующих карбоангидразу, и кетогенной диеты [11,27,65,103,104]. E. Paul et al (2010) оцени-вали переносимость топирамата или Зонеграна в со-четании с кетогенной диетой.…”

Section: эффективность зонисамида в лечении эпилепсииunclassified

Zonisamide (Zonegran) in the Treatment of Epilepsy in Adults and Children (A Review and Clinical Case)

Мухин¹,

Пылаева²

2015

Rus. ž. det. nevrol.

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Acute Kidney Injury Caused by Zonisamide-Induced Hypersensitivity Syndrome

Abstract: Drug rash with eosinophilia and systemic symptoms (DRESS)

Cited by 26 publications

References 18 publications

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

Comparing Zonisamide With Sodium Valproate in the Management of Migraine Headaches: Double-Blind Randomized Clinical Trial of Efficacy and Safety

Zonisamide (Zonegran) in the Treatment of Epilepsy in Adults and Children (A Review and Clinical Case)

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