Acute kidney injury in an infectious disease intensive care unit - an assessment of prognostic factors

Ef, Daher; Cn, Marques; Rs, Lima; Gb, Silva Júnior; Barbosa, Angela Silva; Es, Barbosa; Rm, Mota; S, Leite da Silva; Sm, Araújo; Ab, Libório

doi:10.4414/smw.2008.12062

Cited by 15 publications

(4 citation statements)

References 32 publications

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“…The current study had majority of young patients (mean age 46.1±14.24 years) and most were males (51.9%). Epidemiological data confirmed that these finding were consistent with earlier reports 6,[16][17][18] with respect to a younger age group. Male gender was considered a significant factor associated with AKI probably due to more frequent vascular diseases.…”

Section: Discussionsupporting

confidence: 92%

The aetiology, risk factors and outcome of acute kidney injury in patients requiring kidney replacement therapy – a prospective single center experience

Abbas,

Elahi,

Manan

et al. 2023

J Pak Med Assoc

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Objective: To find out the causes, associated leading factors and impact of kidney replacement therapy on patients hospitalised for acute kidney injury in a tertiary care setting. Method: The prospective, cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from January 1 to March 31, 2022, and comprised patients of either gender aged 18 or more years presenting with acute kidney injury as per the Kidney Disease Improving Global Outcomes criteria and required kidney replacement therapy. Complete, partial or no recovery was the main outcome parameter noted at the end of 90 days. Possible aetiologies were identified and categorised as pre-renal, renal and post-renal aetiologies. Risk factors for acute kidney injury were recorded, including age, gender and co-morbidities. Data was analysed using SPSS 22. Results: Of the 210 patients with mean age 46.1±14.24 years, 109(52%) were males and 101(48%) were females (p>0.05). Hypertension was the most common comorbidity 98(46.8%), followed by diabetes mellitus 75(35.7%) and underlying chronic kidney disease 55(26.2%). Multiple therapeutic interventions were required, including vasopressors in 101(48.1%) patients and mechanical ventilation in 31(14.8%). Renal failure due to intrinsic renal aetiology was the most common 98(46.7%), followed by post-renal aetiology 61(29%). There was no significant association between outcomes and aetiologies (p>0.05). There was increase in chronic kidney disease cases from 55(26.2%) patients at baseline to 107(50.9%) at the end of 90 days. Complete recovery was noted in 71(33.8%) patients, partial in 73(34.76%), no recovery in 34(16.1%) patients who required maintenance kidney replacement therapy, and 32(15.2%) patients died. Conclusion: Complete recovery after 90 days of kidney replacement therapy was observed in one-third of the patients. Intrinsic renal aetiology was the most prevalent, and hypertension was the most common comorbidity. Key Words: AKI, CKD, KRT.

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Section: Discussionsupporting

confidence: 92%

The aetiology, risk factors and outcome of acute kidney injury in patients requiring kidney replacement therapy – a prospective single center experience

Abbas,

Elahi,

Manan

et al. 2023

J Pak Med Assoc

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“…21 Os fatores de risco independentes para óbito neste estudo foram: diagnóstico clínico, elevados níveis de creatinina, ureia, sódio e lactato na admissão e necessidade de ventilação mecânica invasiva. A oligúria ocorre frequentemente em pacientes com IRA na UTI e é mais sensível do que elevações na creatinina plasmática, 22 sendo reconhecida como um preditor precoce de alta mortalidade em pacientes críticos, porém, neste estudo não se mostrou preditora de mortalidade. No estudo de Peres et al, 15 a oligúria foi fator independente de óbito.…”

Section: Discussionunclassified

Predictors of acute kidney injury and mortality in an Intensive Care Unit

Peres¹,

Wandeur²,

Matsuo³

2015

Jornal Brasileiro De Nefrologia

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“…However, this was much higher as compared to tropical regions of south America where the incidence of AKI due to infectious etiology was low. 2,4,7 This shows wide variations of the incidence of AKI in different geographical regions of the world. The reason for this high proportion of AKI in our study could be because we use KDIGO classification for AKI which has greater sensitivity as compared to RIFLE and AKIN classification.…”

Section: Discussionmentioning

confidence: 96%

Spectrum of acute kidney injury in patients of tropical acute febrile illness in a tertiary hospital

2023

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Background: Tropical acute febrile illnesses (TAFI) such as malaria, typhoid, leptospirosis, dengue are major causes of AKI in the tropics. The spectrum of AKI due to TAFI in developing countries like India is still underestimated. Hence, we conducted a study to know the spectrum of AKI in patients of TAFI. Methods: The prospective study was conducted in Yashoda hospital, Secunderabad a tertiary care hospital in India from April 2019 to March 2020. AKI was defined as per KDIGO. The clinical history, physical examination and laboratory investigations were recorded in a standard proforma. Results: Hundred patients suffering from TAFI were admitted during the study period. Mean age of the study population was 43.12±14.33 years. Twenty-six (60.5%) were males. Most common presenting feature was fever (100%), chills (81.4%) and vomiting (67.4%). The most common cause of TAFI was dengue (n=49, 49%), leptospirosis (n=20, 20%), followed by malaria (n=10, 10%), scrub typhus (n=10, 10%) and undifferentiated fever (n=6, 6%). 43 patients (43%) had AKI as per KDIGO definition. 23 patients (53.5%) had stage 1, 11 (25.6%) had stage 2 and 9 (20.9%) had stage 3 AKI. RRT was required in 16.3% of patients. Dengue and leptospirosis were the most common causes for requirement of RRT. SLED was the most common modality of dialysis. Mortality was observed in 6.98% patients and Dengue was the most common cause of mortality. Conclusions: AKI is common in tropical acute febrile illness. However, RRT was required only in 16.3% and mortality was observed in 6.98% patients.

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Acute kidney injury in an infectious disease intensive care unit - an assessment of prognostic factors

Cited by 15 publications

References 32 publications

The aetiology, risk factors and outcome of acute kidney injury in patients requiring kidney replacement therapy – a prospective single center experience

The aetiology, risk factors and outcome of acute kidney injury in patients requiring kidney replacement therapy – a prospective single center experience

Predictors of acute kidney injury and mortality in an Intensive Care Unit

Spectrum of acute kidney injury in patients of tropical acute febrile illness in a tertiary hospital

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