Acute Kidney Injury Predicts Outcomes of Non-Critically Ill Patients

Barrantes, Fidel; Feng, Yan; Иванов, О. А.; Yalamanchili, Hima Bindu; Patel, Janki; Buenafe, Xander; Cheng, Vicky; Dijeh, Sylvester; Amoateng-Adjepong, Yaw; Manthous, Constantine A.

doi:10.1016/s0025-6196(11)60559-4

Cited by 38 publications

(23 citation statements)

References 21 publications

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“…It has been shown that the AKIN classification, like the RIFLE classification, allowed the identification and stratification of AKI in a large proportion of hospitalized patients and was independently associated with the outcome [34, 48–56]. In fact, patients with AKI had higher in-hospital mortality and longer lengths of stay, and AKI survivors were more likely to be discharged to an extended care facility.…”

Section: The Acute Kidney Injury Network (Akin) Classificationmentioning

confidence: 99%

The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review

2013

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In May 2004, a new classification, the RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) classification, was proposed in order to define and stratify the severity of acute kidney injury (AKI). This system relies on changes in the serum creatinine (SCr) or glomerular filtration rates and/or urine output, and it has been largely demonstrated that the RIFLE criteria allows the identification of a significant proportion of AKI patients hospitalized in numerous settings, enables monitoring of AKI severity, and is a good predictor of patient outcome. Three years later (March 2007), the Acute Kidney Injury Network (AKIN) classification, a modified version of the RIFLE, was released in order to increase the sensitivity and specificity of AKI diagnosis. Until now, the benefit of these modifications for clinical practice has not been clearly demonstrated.Here we provide a critical and comprehensive discussion of the two classifications for AKI, focusing on the main differences, advantages and limitations.

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Section: The Acute Kidney Injury Network (Akin) Classificationmentioning

confidence: 99%

The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review

2013

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“…[1][2][3][4] Even a relatively small degree of renal injury increases a patient's risk of a prolonged hospital stay, chronic kidney disease (CKD), ESRD, and death. 2,[5][6][7][8][9][10] Over the last 2 decades, the incidence of hospitalized AKI has increased dramatically. [11][12][13][14] Precise estimations vary depending on population and method of case identification, but a recent community-based study of AKI estimated the incidence of nondialysis requiring AKI at 522 per 100,000 population per year and dialysis-requiring AKI at 30 per 100,000, 13 which is well over that of ESRD.…”

mentioning

confidence: 99%

Albuminuria and Estimated Glomerular Filtration Rate Independently Associate with Acute Kidney Injury

Grams

Astor

Bash³

et al. 2010

Journal of the American Society of Nephrology

151

116

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Acute kidney injury (AKI) is increasingly common and a significant contributor to excess death in hospitalized patients. CKD is an established risk factor for AKI; however, the independent graded association of urine albumin excretion with AKI is unknown. We analyzed a prospective cohort of 11,200 participants in the Atherosclerosis Risk in Communities (ARIC) study for the association between baseline urine albumin-to-creatinine ratio and estimated GFR (eGFR) with hospitalizations or death with AKI. The incidence of AKI events was 4.0 per 1000 person-years of follow-up. Using participants with urine albumin-to-creatinine ratios Ͻ10 mg/g as a reference, the relative hazards of AKI, adjusted for age, gender, race, cardiovascular risk factors, and categories of eGFR were 1.9 (95% CI, 1.4 to 2.6), 2.2 (95% CI, 1.6 to 3.0), and 4.8 (95% CI, 3.2 to 7.2) for urine albumin-to-creatinine ratio groups of 11 to 29 mg/g, 30 to 299 mg/g, and Ն300 mg/g, respectively. Similarly, the overall adjusted relative hazard of AKI increased with decreasing eGFR. Patterns persisted within subgroups of age, race, and gender. In summary, albuminuria and eGFR have strong, independent associations with incident AKI.

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“…Volkmann et al [20] demonstrated that AKI may be hidden in over 25% of patients who underwent CABG. Thus, the existence of a classification criterion to detect early kidney as well as a proposal to unify the classification/definition of AKI are essencial [4,6,7].…”

Section: Discussionmentioning

confidence: 99%

“…The term AKI is used to reflect the entire spectrum of what is defined as the abrupt reduction in renal function, in hours or days, in which acute renal failure (ARF) is characterized by a decrease in the glomerular filtration rate and/or urinary volume, in addition to the loss of basic functions, such as the inability to maintain the hydro-electrolyte and basic acid balance [2]. Most estimates demonstrates that over 30% of patients undergoing cardiac surgery develop clinically severe renal damage [3], with the need for dialysis ranging from 1.4% to 7% [4,5] and mortality rate of 5% to 44% [6,7].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury after coronary artery bypass grafting: assessment using RIFLE and AKIN criteria

Nina¹,

Matias²,

Brito³

et al. 2013

Revista Brasileira De Cirurgia Cardiovascular

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Acute Kidney Injury Predicts Outcomes of Non-Critically Ill Patients

Abstract: In this study, AKI was associated with adverse outcomes in non-critically ill patients.

Cited by 38 publications

References 21 publications

The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review

The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review

Albuminuria and Estimated Glomerular Filtration Rate Independently Associate with Acute Kidney Injury

Acute kidney injury after coronary artery bypass grafting: assessment using RIFLE and AKIN criteria

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