Acute kidney injury: taking aim at colistin

Rashid, Shayan; Saro-Nunez, Lilian; Kumar, Akanksha; Patel, Amit A.; Parikh, Amay

doi:10.1186/cc13703

Cited by 3 publications

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References 3 publications

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“…Although of considerable interest, we would like to challenge the paper by Rocco and colleagues regarding the administered colistin loading and maintenance doses, in particular during continuous renal replacement therapy. We agree with Rachid and colleagues [ 2 ] that recent pharmacokinetic data suggest the administration of higher and thus potentially more nephrotoxic, colistin doses for treatment of multidrug-resistant Pseudomonas species. In fact, the recommended loading and maintenance doses to adequately treat severe multidrug-resistant Pseudomonas infections should be, respectively, 9 million IU and 4.5 million IU twice a day [ 3 ], which is substantially higher than the doses used by Rocco and colleagues.…”

supporting

confidence: 91%

“…We read with great interest the article by Rocco and colleagues [ 1 ] that retrospectively evaluated risk factors for acute kidney injury in critically ill patients receiving colistin and the subsequent comments by Rachid and colleagues [ 2 ]. Although of considerable interest, we would like to challenge the paper by Rocco and colleagues regarding the administered colistin loading and maintenance doses, in particular during continuous renal replacement therapy.…”

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confidence: 99%

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Colistin dosing for treatment of multidrug-resistant Pseudomonas in critically ill patients - please, be adequate!

et al. 2014

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confidence: 91%

mentioning

confidence: 99%

Colistin dosing for treatment of multidrug-resistant Pseudomonas in critically ill patients - please, be adequate!

et al. 2014

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“…We thank Rashid and colleagues [ 1 ] and Honoré and colleagues [ 2 ] for their comments regarding our article on risk factors for acute kidney injury in patients receiving colistin or other nephrotoxic antimicrobials [ 3 ].…”

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confidence: 99%

Dose of colistin: a work in progress?

et al. 2015

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Nefrotoxicity Caused by Colistin Use: A Single Center Experience

KILIC

Ayar

Ceylan³

et al. 2023

Preprint

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Aim In resistant infections and septic patients, the choice of colistin in the selection of antibiotic therapy is important in the treatment response. Kidney damage is common after antibiotic use. In our study, we evaluated the clinical and laboratory data of the patients who developed nephrotoxicity after the use of colistin, followed in the intensive care unit of our hospital. Material and Methods The clinical and laboratory characteristics and treatment results of 148 patients (54 nephrotoxic patients) with infection who were followed up in the intensive care unit (ICU) of our hospital evaluated. Results The group that developed nephrotoxicity was older [70.5 (40–91), p < 0.001]. The APACHE II score was higher in the nephrotoxicity group [20.5 (5–49), p = 0.004]. Positive inotrope use and mortality were higher in the nephrotoxicity group [32 (59.3%), p < 0.001 and 30 (55.6%), p = 0.004]. The duration of colistin use was longer in the nephrotoxicity group [13.5 (3–36), p = 0.045]. In the group that developed nephrotoxicity, the highest growth was detected in the tracheal aspirate (TAS) [49 (90.7%), p = 0.045]. Positive inotrope use and growth in TAS culture predisposed the development of nephrotoxicity in multivariate analysis [3.12 (1.38–7.02), CI 95%, p = 0.006, 5.70 (1.64–19.79), CI 95%, p = 0.006]. Conclusion Consideration should be given to the use of colistin in resistant infections and septic patients in terms of nephrotoxicity and mortality. Antibiotic selection should be considered in critically ill patients, and patients should be closely monitored.

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Acute kidney injury: taking aim at colistin

Cited by 3 publications

References 3 publications

Colistin dosing for treatment of multidrug-resistant Pseudomonas in critically ill patients - please, be adequate!

Colistin dosing for treatment of multidrug-resistant Pseudomonas in critically ill patients - please, be adequate!

Dose of colistin: a work in progress?

Nefrotoxicity Caused by Colistin Use: A Single Center Experience

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